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公开(公告)号：US10246533B2
公开(公告)日：2019-04-02
申请号：US14970192
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09868826B2
公开(公告)日：2018-01-16
申请号：US15200533
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Talha M. Gokmen , Pontus Lundberg , Prasanna Krishnan Thwar , Alfred Lui , Lily Lu , Wolfgang Hinz , Lene Husaboe , Elisabeth Breivold , Astrid Evenroed Molteberg , Synne Larsen
IPC: C08J3/075 , C08F220/58 , C08F8/12 , C08F220/70 , C08F230/08
CPC classification number: C08J3/075 , C08F8/12 , C08F220/58 , C08F220/70 , C08F2230/085 , C08J2333/26 , C08F222/38
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：US20160186166A1
公开(公告)日：2016-06-30
申请号：US14964060
申请日：2015-12-09
Applicant: Life Technologies Corporation , Thermo Fisher Scientific Geneart Gmbh , Life Technologies As
Inventor： Thomas POEHMERER , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
CPC classification number: C12N15/101 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C5/026 , B03C2201/26 , C25B3/10 , C25B9/18 , C25B11/04 , C25B15/02
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20140179025A1
公开(公告)日：2014-06-26
申请号：US14190054
申请日：2014-02-25
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen Weng , Geir Fonnum , Grete Modahl , Astrid Molteberg , Erling Finne
IPC: G01N33/543
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
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公开(公告)号：US20130035418A1
公开(公告)日：2013-02-07
申请号：US13649045
申请日：2012-10-10
Applicant: Life Technologies AS
Inventor： Arne JORGEDAL , Elin Asknes , Geir Fonnum , Astrid Molteberg , Rolf Nordal , Henning Pettersen , Tollef Taarneby , Solveig Staale , Ellen Weng , Finn Hansen , Silje Nordbo , Oddvar Aune , Arvid Berge , John Bjorgum , Turid Ellingsen , John Ugelstad
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
Abstract translation: 通过使单体与包含单分散可溶胀种子聚合物/低聚物的水性分散体接触而形成的单分散聚合物颗粒的制备方法，以及在空间稳定剂存在下引发聚合。 所得的溶胀种子颗粒的特征在于颗粒模式直径。
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Patent Agency Ranking
公开(公告)号：US20230272127A1
公开(公告)日：2023-08-31
申请号：US18143880
申请日：2023-05-05
Applicant: Life Technologies AS
Inventor： Per Nils Pontus Lundberg , Geir Fonnum , Kristian Andersson
IPC: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26
CPC classification number: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26 , C08K3/22
Abstract: This invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.6; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse coated hydrogel polymer particles.
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公开(公告)号：US20200010827A1
公开(公告)日：2020-01-09
申请号：US16518099
申请日：2019-07-22
Applicant: THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US10189956B2
公开(公告)日：2019-01-29
申请号：US15871863
申请日：2018-01-15
Applicant: Life Technologies AS , Life Technologies Corporation
Inventor： Geir Fonnum , Steven M. Menchen , M. Talha Gokmen , Pontus Lundberg , Prasanna Krishnan Thwar , Alfred Lui , Lily Lu , Wolfgang Hinz , Lene Husaboe , Elisabeth Breivold , Astrid Evenroed Molteberg , Synne Larsen
IPC: C08F8/12 , C08J3/075 , C08F220/58 , C08F220/70 , C08F230/08
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：US20170002410A1
公开(公告)日：2017-01-05
申请号：US15200588
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Alfred Lui , Guobing Xiang , Synne Larsen
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6869 , C12Q1/6874 , C12Q2525/197 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629
Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
Abstract translation: 聚合物基质，例如聚合物涂层或聚合物水凝胶网络，包括羧基部分，其可以用作受体或分析物分子可以连接到的缀合位点。 在一个实例中，聚合物底物包括具有链烷酸部分或其衍生物的聚丙烯酰胺聚合物网络，其可以与羧基活化化合物反应，以在聚丙烯酰胺网络上提供活化的链烷酸酯部分。胺封端的核酸可以与活化的链烷酸酯部分反应 通过烷基酰胺部分将核酸捕获到聚合物网络。
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公开(公告)号：US11130833B2
公开(公告)日：2021-09-28
申请号：US17066326
申请日：2020-10-08
Applicant: Life Technologies AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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