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公开(公告)号:US07098202B2
公开(公告)日:2006-08-29
申请号:US10760125
申请日:2004-01-20
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号: A61K31/33 , C07D277/04
CPC分类号: C07D307/79 , A61K38/00 , C07D235/30 , C07D277/62 , C07D295/15 , C07D311/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07D405/12 , C07D405/14 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069
摘要: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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公开(公告)号:US07045518B2
公开(公告)日:2006-05-16
申请号:US10677729
申请日:2003-10-03
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Raj Nagarajan , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Raj Nagarajan , Joseph J. McDonald
IPC分类号: A61K31/343 , A61K31/357 , A61K31/428 , C07D277/62 , C07D317/62
CPC分类号: C07D263/56 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/20 , C07D277/62 , C07D277/82 , C07D307/79 , C07D307/82 , C07D311/58 , C07D317/62 , C07D319/18
摘要: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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23.Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors 失效
标题翻译: 磺酰基烷酰氨基羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号:US06380188B1
公开(公告)日:2002-04-30
申请号:US09672449
申请日:2000-09-29
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagaraian , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagaraian , Joseph J. McDonald
IPC分类号: A61K31343
CPC分类号: C07D235/06 , C07C311/29 , C07C311/41 , C07C317/44 , C07D215/36 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/18 , C07D249/20 , C07D263/56 , C07D277/62 , C07D277/82 , C07D303/36 , C07D307/79 , C07D317/62 , C07D319/18
摘要: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译: 选择的磺酰基烷酰基氨基羟基胺磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。 本发明涉及这种逆转录病毒蛋白酶抑制剂,更具体地涉及所选择的新化合物,用于抑制逆转录病毒蛋白酶如人类免疫缺陷病毒(HIV)蛋白酶的组合物和方法,预防性地预防逆转录病毒感染或逆转录病毒的扩散,以及 治疗逆转录病毒感染。
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24.Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors 失效
标题翻译: 氨基酸羟乙基氨基磺酰胺逆转录病毒蛋白酶抑制剂公开(公告)号:US5968970A
公开(公告)日:1999-10-19
申请号:US894900
申请日:1998-01-02
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan R. Nagarajan , David L. Brown , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan R. Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号: C07D317/46 , A61K31/357 , A61K31/36 , A61K31/4025 , A61K31/4035 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07D235/30 , C07D263/56 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/58 , C07D317/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07K5/06 , C07K5/08 , A61K31/40 , C07D207/06
CPC分类号: C07D307/79 , C07D311/58 , C07D317/62 , C07D319/18 , C07D339/06 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069 , A61K38/00
摘要: Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.
摘要翻译: PCT No.PCT / US96 / 02684第 371日期:1998年1月12日 102(e)日期1998年1月12日PCT 1996年3月7日PCT公布。 WO96 / 28463 PCT出版物 日期1996年9月19日描述了下式的逆转录病毒蛋白酶抑制化合物:或其药学上可接受的盐,前药或酯。
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公开(公告)号:US06667307B2
公开(公告)日:2003-12-23
申请号:US10082123
申请日:2002-02-26
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
IPC分类号: A61K31343
CPC分类号: C07D263/56 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/20 , C07D277/62 , C07D277/82 , C07D307/79 , C07D307/82 , C07D311/58 , C07D317/62 , C07D319/18
摘要: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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26.
公开(公告)号:US5776971A
公开(公告)日:1998-07-07
申请号:US474117
申请日:1995-06-07
申请人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
发明人: Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , David L. Brown , Joseph J. McDonald
IPC分类号: A61K38/00 , C07K5/078 , A61K31/40 , C07D207/48
CPC分类号: C07K5/06165 , C07K5/06139 , A61K38/00
摘要: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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27.
公开(公告)号:US5968942A
公开(公告)日:1999-10-19
申请号:US294468
申请日:1994-08-23
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
IPC分类号: A61K31/18 , A61K31/34 , A61K31/38 , A61K31/44 , A61K31/495 , A61K31/535 , A61K38/00 , C07C303/00 , C07C311/05 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/10 , C07C317/14 , C07C317/44 , C07C323/67 , C07D207/46 , C07D209/08 , C07D211/70 , C07D211/72 , C07D213/24 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/54 , C07D239/26 , C07D265/30 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/93 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/36 , C07D405/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/36 , C07D317/50
CPC分类号: C07C311/05 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D263/34 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D405/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/18 , C07C2102/10
摘要: .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号:US5482947A
公开(公告)日:1996-01-09
申请号:US152934
申请日:1993-11-15
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C04B35/632 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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29.&agr;-and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰胺公开(公告)号:US06417387B1
公开(公告)日:2002-07-09
申请号:US09798255
申请日:2001-03-05
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
IPC分类号: C07C30300
CPC分类号: C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D263/34 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D405/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139
摘要: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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30.α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 有权
标题翻译: α-和β-二羧酸 - 氨基酸羟乙基氨基磺酰胺,可用作逆转录病毒蛋白酶抑制剂公开(公告)号:USRE42889E1
公开(公告)日:2011-11-01
申请号:US11788947
申请日:2007-04-23
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Robert M. Heintz , Deborah E. Bertenshaw
IPC分类号: A61K31/36 , C07D317/50
CPC分类号: C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D261/08 , C07D263/34 , C07D263/56 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/45 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139
摘要: α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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