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317 条记录 (耗时 0.107 秒)

    Antibodies that specifically bind to chemokine beta-4
    23.
    发明授权
    Antibodies that specifically bind to chemokine beta-4 失效
    特异性结合趋化因子β-4的抗体

    公开(公告)号：US07375192B2

    公开(公告)日：2008-05-20

    申请号：US10513705

    申请日：2003-04-30

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/00

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

    摘要翻译： 本发明涉及特异性结合CK-B4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括癌症在内的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 ，牛皮癣，皮炎和炎性肠病。 本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。

    Peptidoglycan recognition proteins
    24.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07368244B2

    公开(公告)日：2008-05-06

    申请号：US11214796

    申请日：2005-08-31

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07H21/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
    25.
    发明授权
    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
    使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法

    公开(公告)号：US07361341B2

    公开(公告)日：2008-04-22

    申请号：US11391384

    申请日：2006-03-29

    申请人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    发明人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C07K16/2878 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体 或相关分子，其免疫特异性结合TRAIL受体TR4。

    Antibodies that immunospecifically bind to B lymphocyte stimulator protein
    27.
    发明授权
    Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
    免疫特异性结合B淋巴细胞刺激蛋白的抗体

    公开(公告)号：US07220840B2

    公开(公告)日：2007-05-22

    申请号：US10293418

    申请日：2002-11-14

    申请人： Steven M. Ruben ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    发明人： Steven M. Ruben ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： G01N33/564 ,  A61K35/12 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

    摘要翻译： 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。

    Method of treating reproductive system cancer by administering follistatin-3
    28.
    发明授权
    Method of treating reproductive system cancer by administering follistatin-3 有权
    通过施用卵泡抑素-3治疗生殖系统癌症的方法

    公开(公告)号：US07208470B2

    公开(公告)日：2007-04-24

    申请号：US11155114

    申请日：2005-06-17

    申请人： D. Roxanne Duan ,  Steven M. Ruben

    发明人： D. Roxanne Duan ,  Steven M. Ruben

    IPC分类号： A61K38/17

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021 ,  C12N2799/026

    摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

    摘要翻译： 本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。 特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。 还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。

    Antibodies against tumor necrosis factor delta (APRIL)
    30.
    发明授权
    Antibodies against tumor necrosis factor delta (APRIL) 失效
    抗肿瘤坏死因子δ（APRIL）抗体

    公开(公告)号：US07189820B2

    公开(公告)日：2007-03-13

    申请号：US10151882

    申请日：2002-05-22

    申请人： Steven M. Ruben

    发明人： Steven M. Ruben

    IPC分类号： C12P21/08 ,  C12P21/04 ,  C07K16/00 ,  A61K39/395 ,  C12N7/01 ,  C12N5/06

    CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, treating, preventing, or ameliorating a disease or disorder associated with aberrant APRIL or APRIL receptor expression or aberrant function of APRIL or APRIL receptor, comprising antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to APRIL. In particular, the present invention further relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating autoimmune diseases or disorder, such as systemic lupus erythematosus Rheumatoid arthritis, and Sjögren's syndrome, or cancers of the immune system, particularly B cell cancers such as non-Hodgkin's lymphoma and multiple myeloma, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to APRIL.

    摘要翻译： 本发明涉及免疫特异性结合肿瘤坏死因子三角（TNF-δ; APRIL）的抗体和相关分子。 本发明还涉及用于检测，诊断，预后，治疗，预防或改善与APRIL或APRIL受体的异常APRIL或APRIL受体表达或异常功能相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体 ，或与APRIL免疫特异性结合的相关分子。 特别地，本发明还涉及用于检测，诊断，预后，预防，治疗或改善自身免疫性疾病或病症的系统和组合物，例如系统性红斑狼疮类风湿性关节炎和Sjögren综合征，或免疫系统的癌症，特别是B 细胞癌例如非霍奇金淋巴瘤和多发性骨髓瘤，包括向动物，优选人类施用有效量的一种或多种免疫特异性结合APRIL的抗体或其片段或变体或相关分子。