公开(公告)号：US20220338768A1

公开(公告)日：2022-10-27

申请号：US17226412

申请日：2021-04-09

Applicant: Medtronic MiniMed, Inc.

Inventor： Melissa Tsang ,  Michael N. Missaghi ,  Anna Miller ,  Chi-En Lin ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Nicole Abraham

IPC: A61B5/1486 ,  A61B5/145 ,  B05D1/00

Abstract: Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of hexamethyldisiloxane useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

公开(公告)号：US11311215B2

公开(公告)日：2022-04-26

申请号：US16375752

申请日：2019-04-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chi-En Lin ,  David Probst ,  Mohsen Askarinya ,  Akhil Srinivasan ,  Melissa Tsang ,  Michael E. Miller ,  Parisa Kamgar

IPC: A61B5/145 ,  A61B5/1486 ,  G01N27/327 ,  C12Q1/54 ,  G01N27/02 ,  A61B5/00 ,  C12Q1/00

Abstract: The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

公开(公告)号：US20190242010A1

公开(公告)日：2019-08-08

申请号：US15892172

申请日：2018-02-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Yifei Wang

IPC: C23C14/54 ,  C23C14/34 ,  C23C14/30

CPC classification number: C23C14/545 ,  A61B5/14532 ,  C23C14/0005 ,  C23C14/025 ,  C23C14/18 ,  C23C14/30 ,  C23C14/34

Abstract: A method of depositing of a film on a substrate with controlled adhesion. The method comprises depositing the film including metal, wherein the metal is deposited on the substrate using physical vapor deposition at a pressure that achieves a pre-determined adhesion of the film to the substrate. The pre-determined adhesion allows processing of the film into a device while the film is adhered to the substrate but also allows removal of the device from the substrate.

公开(公告)号：US20190008425A1

公开(公告)日：2019-01-10

申请号：US15922718

申请日：2018-03-15

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Melissa Tsang ,  Robert C. Mucic ,  Tyler R. Wong ,  Rui Kong ,  Barry P. Pham

IPC: A61B5/145 ,  B81B3/00 ,  G01N27/327

Abstract: The invention disclosed herein includes electrode compositions formed from processes that sputter metal in a manner that produces pillar architectures. Embodiments of the invention can be used in analyte sensors having such electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals. However, the metal pillar structures have wide ranging applicability and should increase surface area and decrease charge density for catalyst layers or electrodes used with sensing, power generation, recording, and stimulation, in vitro and/or in the body, or outside the body.

公开(公告)号：US20240398290A1

公开(公告)日：2024-12-05

申请号：US18802086

申请日：2024-08-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Soroush Hossein Yazdi ,  Melissa Tsang ,  Ellis Garai ,  Sadaf S. Seleh ,  Steven Lai ,  Luis A. Torres ,  Bradley Petkus ,  Xin Heng ,  Zhenzhong Sun ,  Akhil Srinivasan ,  Tyler R. Wong

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  G16H20/10

Abstract: Methods, systems, and devices for continuous glucose monitoring. More particularly, the methods, systems, and devices describe a working electrode with a GOx sensor and a background electrode in which the background electrode has no GOx sensor. The system may then compare the first signal and the second signal to detect ingestion of a medication by the user. The system may generate a sensor glucose value based on the comparison.

公开(公告)号：US12042284B2

公开(公告)日：2024-07-23

申请号：US15878313

申请日：2018-01-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jia Yao ,  Daniel E. Pesantez ,  Anuradha Biswas Bhatia ,  Akhil Srinivasan ,  Guangping Zhang ,  Andrea Varsavsky ,  Raghavendhar Gautham

IPC: A61B5/1486 ,  A61B5/145 ,  A61L31/04 ,  A61L31/14 ,  C09D5/16 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  A61B5/00

CPC classification number: A61B5/14865 ,  A61B5/1451 ,  A61B5/14532 ,  A61L31/04 ,  A61L31/14 ,  C09D5/1681 ,  C12Q1/006 ,  C12Q1/26 ,  C12Q1/54 ,  A61B5/41 ,  A61L2400/18

Abstract: Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.

公开(公告)号：US11638545B2

公开(公告)日：2023-05-02

申请号：US16654353

申请日：2019-10-16

Applicant: Medtronic MiniMed, Inc.

Inventor： Akhil Srinivasan ,  Tyler Wong ,  Inthirai Somasuntharam

IPC: A61B5/1473 ,  C23C14/14 ,  C23C14/35 ,  A61B5/145

Abstract: Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.

公开(公告)号：US20210077717A1

公开(公告)日：2021-03-18

申请号：US16569401

申请日：2019-09-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Akhil Srinivasan ,  Peter Ajemba ,  Steven C. Jacks ,  Robert C. Mucic ,  Tyler R. Wong ,  Melissa Tsang ,  Chi-En Lin ,  Mohsen Askarinya ,  David Probst

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61B5/1495

Abstract: Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

公开(公告)号：US20210076993A1

公开(公告)日：2021-03-18

申请号：US17025570

申请日：2020-09-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Inthirai Somasuntharam ,  Jake Matteson ,  Matthew Jolly ,  Quyen Ong ,  Akhil Srinivasan ,  Poonam Gulati ,  Andrea Varsavsky ,  Sana Suhail

IPC: A61B5/145 ,  A61B5/1473 ,  A61K31/573

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition that includes amounts of one or more immunosuppressant agents so as to provide such membranes with improved material properties such as enhanced biocompatibility.

公开(公告)号：US20200330007A1

公开(公告)日：2020-10-22

申请号：US16391206

申请日：2019-04-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ellis Garai ,  Akhil Srinivasan ,  David C. Antonio

IPC: A61B5/1477 ,  H01L23/31 ,  H01L23/498 ,  H01L23/66 ,  H01L21/48 ,  H01L23/13 ,  A61B5/145 ,  G01N33/49

Abstract: Analyte sensor devices and methods for fabricating analyte sensor devices are presented here. In accordance with certain embodiments, a device for detecting and/or measuring one or more analytes in fluid includes a substrate and one or more analyte sensors disposed on and/or in the substrate. Further, the device includes an integrated circuit disposed on and/or in the substrate. The integrated circuit is electrically integrated with the analyte sensors.