公开(公告)号：US20100092535A1

公开(公告)日：2010-04-15

申请号：US12249611

申请日：2008-10-10

申请人： Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

发明人： Brian Cook ,  James Mitchell ,  Feridun Ozdil ,  Natividad Vasquez

IPC分类号： A61K9/00 ,  A61K39/395 ,  A61F2/82

CPC分类号： A61F2/04 ,  A61F2/82 ,  A61F2250/0067 ,  A61L17/005 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/12

摘要： Disclosed herein are controlled release drug delivery systems. The systems comprise a medical device at least one nonoporous surface, at least one bioactive agent and optionally a biodegradable polymer. The nanoporous surfaces of the medical devices contain nanopores capable of acting as reservoirs for drugs that are controllably released.

摘要翻译： 本文公开了控释药物递送系统。 该系统包括至少一个非孔表面的医疗装置，至少一种生物活性剂和任选的可生物降解的聚合物。 医疗装置的纳米多孔表面含有能够作为可控制释放的药物的储存器的纳米孔。

公开(公告)号：US20100024672A1

公开(公告)日：2010-02-04

申请号：US12183461

申请日：2008-07-31

申请人： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

发明人： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

IPC分类号： B41M5/00 ,  G03F7/26

CPC分类号： G03F7/40 ,  B41C1/1075 ,  B41C1/1083 ,  G03F7/36

摘要： The present invention pertains to a process and an apparatus for treating a photosensitive element to form a relief structure suitable for flexographic printing plate. The apparatus comprises an enclosure, a conveyor, a heatable roller with absorbent material conducted over it, and a roller that can significantly smooth or uniformly roughen the relief structure of the flexographic printing plate. Previously selectively cured photosensitive elements are developed by means of the heatable roller by blotting with the absorbent material, and the resulting relief structure is made uniform by way of a smoothing or roughening roller. The flexographic plates produced by the method and apparatus are especially suited to processes that require substantially smoothed or uniformly roughened printing plate surfaces, which are capable of producing better quality printing.

摘要翻译： 本发明涉及一种用于处理感光元件以形成适于柔性版印刷版的浮雕结构的方法和设备。 该装置包括外壳，输送机，带有吸收材料的可加热辊，并且能够显着平滑或均匀地粗糙柔性版印刷版的浮雕结构。 先前选择性地固化的感光元件通过用吸收材料吸墨通过可加热辊显影，并且通过平滑或粗糙的辊使得到的浮雕结构均匀。 通过该方法和设备生产的柔版印刷板特别适用于需要基本上平滑或均匀粗糙的印版表面的工艺，其能够生产更好质量的印刷。

公开(公告)号：US20050209284A1

公开(公告)日：2005-09-22

申请号：US11055798

申请日：2005-02-09

申请人： Joerg Bentzien ,  Brian Cook ,  Xiang Li ,  Ho Lo ,  Chuk Man ,  Ingo Mugge ,  Peter Nemoto ,  Steven Pullen ,  Doris Riether ,  Gregory Roth ,  Fariba Soleymanzadeh ,  Hidenori Takahashi ,  Ji Wang ,  Andre White ,  Renee Zindell

发明人： Joerg Bentzien ,  Brian Cook ,  Xiang Li ,  Ho Lo ,  Chuk Man ,  Ingo Mugge ,  Peter Nemoto ,  Steven Pullen ,  Doris Riether ,  Gregory Roth ,  Fariba Soleymanzadeh ,  Hidenori Takahashi ,  Ji Wang ,  Andre White ,  Renee Zindell

IPC分类号： A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07D235/30 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D413/14 ,  C07D417/02 ,  C07D417/14 ,  C07D491/10 ,  C07D43/02

CPC分类号： C07D235/30 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D491/10

摘要： Disclosed are compounds of formula(I): wherein Ar1, Ar2, R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

摘要翻译： 公开了式（I）的化合物：其中Ar 1，Ar 2，R 1，R 2， R 3，R 4和X a a在本文中定义。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US20050185037A1

公开(公告)日：2005-08-25

申请号：US11063796

申请日：2005-02-23

申请人： Thomas Bailey ,  Jeffery Buchanan ,  Johnnie Coffey ,  Brian Cook ,  David Greer ,  Ganesh Phatak

发明人： Thomas Bailey ,  Jeffery Buchanan ,  Johnnie Coffey ,  Brian Cook ,  David Greer ,  Ganesh Phatak

IPC分类号： B41J2/175

CPC分类号： B41J2/17513 ,  B41J2/17553

摘要： Multi-compartmentalized ink cartridges for ink jet printers and improved methods for making the ink cartridges. The multi-compartmentalized ink cartridge includes a molded, open-topped body having an interior cavity and a printhead surface area opposite the interior cavity. A divider wall is integrally molded with the molded body structure and disposed in the interior cavity to provide at least three segregated ink chambers. The divider wall includes a first wall section and a second wall section attached substantially perpendicular to the first wall section. At least first, second, third molded ink flow paths connect each of the at least three segregated ink chambers with the printhead surface area. The second and third ink flow paths are oriented relative to their corresponding ink chambers for molding with a mold insert tool so that the cartridge body does not require a separately attached member to close mold insert tool insertion areas in the body.

摘要翻译： 用于喷墨打印机的多间隔墨盒和用于制造墨盒的改进方法。 多间隔墨盒包括具有内腔和与内腔相对的打印头表面区域的模制的开顶本体。 分隔壁与成型体结构整体模制并且设置在内腔中以提供至少三个分离的墨室。 分隔壁包括基本上垂直于第一壁部分附接的第一壁部分和第二壁部分。 至少第一，第二，第三模制油墨流动路径将至少三个分离的油墨室中的每一个连接到打印头表面区域。 第二和第三墨水流动路径相对于其相应的墨水腔定向，以便用模具插入工具进行模制，使得墨盒主体不需要单独附接的构件来封闭体内的模具插入工具插入区域。

公开(公告)号：US08796544B2

公开(公告)日：2014-08-05

申请号：US11639372

申请日：2006-12-14

申请人： Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

发明人： Andreas Mershin ,  Brian Cook ,  Shuguang Zhang

IPC分类号： H01G9/20 ,  H01L51/42

CPC分类号： H01G9/2027 ,  B82Y10/00 ,  B82Y30/00 ,  H01G9/204 ,  H01G9/2059 ,  H01L51/0093 ,  Y02E10/542 ,  Y02E10/549

摘要： The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.

摘要翻译： 本发明提供一种湿或干生物敏化光电转换装置（光电检测器或光伏），其包括：稳定的生物衍生的敏化剂，例如沉积在纳米线，半导体材料，电极上的稳定的光系统I（PS-1） 支持。 纳米线提供更大的光吸收层的表面积以获得更好的能量转换效率，并且被选择为补充敏化剂的吸收光谱并保护敏化剂免受漂白。

公开(公告)号：US08739701B2

公开(公告)日：2014-06-03

申请号：US12183461

申请日：2008-07-31

申请人： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

发明人： Ryan Vest ,  Brian Cook ,  Jim Hennessy ,  David Elwell

IPC分类号： B41N6/00 ,  G03F7/00

CPC分类号： G03F7/40 ,  B41C1/1075 ,  B41C1/1083 ,  G03F7/36

摘要： The present invention pertains to a process and an apparatus for treating a photosensitive element to form a relief structure suitable for flexographic printing plate. The apparatus comprises an enclosure, a conveyor, a heatable roller with absorbent material conducted over it, and a roller that can significantly smooth or uniformly roughen the relief structure of the flexographic printing plate. Previously selectively cured photosensitive elements are developed by means of the heatable roller by blotting with the absorbent material, and the resulting relief structure is made uniform by way of a smoothing or roughening roller. The flexographic plates produced by the method and apparatus are especially suited to processes that require substantially smoothed or uniformly roughened printing plate surfaces, which are capable of producing better quality printing.

摘要翻译： 本发明涉及一种用于处理感光元件以形成适于柔性版印刷版的浮雕结构的方法和设备。 该装置包括外壳，输送机，带有吸收材料的可加热辊，并且能够显着平滑或均匀地粗糙柔性版印刷版的浮雕结构。 先前选择性地固化的感光元件通过用吸收材料吸墨通过可加热辊显影，并且通过平滑或粗糙的辊使得到的浮雕结构均匀。 通过该方法和设备生产的柔版印刷板特别适用于需要基本上平滑或均匀粗糙的印版表面的工艺，其能够生产更好质量的印刷。

公开(公告)号：US20120043767A1

公开(公告)日：2012-02-23

申请号：US13211209

申请日：2011-08-16

申请人： David A. Fehr ,  Wayne A. Knepp ,  Brian Cook

发明人： David A. Fehr ,  Wayne A. Knepp ,  Brian Cook

IPC分类号： E05C3/16

CPC分类号： E05B65/0817 ,  E05B53/003 ,  E05B65/0882 ,  E05C17/48 ,  E05C17/60 ,  E05C19/04 ,  Y10T292/03 ,  Y10T292/0807 ,  Y10T292/0911 ,  Y10T292/0915 ,  Y10T292/0917 ,  Y10T292/1084

摘要： A sliding door latching and locking system is disclosed which includes a latch assembly, a lift rod assembly, and a retainer assembly, among other things. In some embodiments, the latch assembly includes a support member mounted in a movable body and a latching arm pivotally mounted to the support member having a distal end thereof extending outside of the periphery of the movable body, wherein the distal end includes an engagement facilitating portion with a sloped outer surface for contacting an interlocking member.

摘要翻译： 公开了一种滑动门闩锁和锁定系统，其包括闩锁组件，提升杆组件和保持器组件等。 在一些实施例中，闩锁组件包括安装在可移动体中的支撑构件和可枢转地安装到支撑构件的闩锁臂，该支撑构件的远端延伸到可移动体的周边的外侧，其中远端包括接合促进部分 具有用于接触互锁构件的倾斜的外表面。

公开(公告)号：US20120021932A1

公开(公告)日：2012-01-26

申请号：US13015851

申请日：2011-01-28

申请人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

发明人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

IPC分类号： C40B30/04 ,  C40B40/10 ,  G01N21/75 ,  G01N21/55 ,  G01N24/08

CPC分类号： G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

摘要翻译： 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US20100021620A1

公开(公告)日：2010-01-28

申请号：US12179783

申请日：2008-07-25

申请人： Paul Coates ,  Brian Cook

发明人： Paul Coates ,  Brian Cook

IPC分类号： B05D3/12

CPC分类号： C23C14/12 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  C23C14/024

摘要： A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.

摘要翻译： 通过在具有植入式医疗装置（诸如其中装载的支架）的沉积室中蒸发药物来形成药物涂层。 利用真空来降低沉积室内的压力，从而降低蒸发药物所需的温度。 然后将药物在气相中沉积到可植入医疗装置上以形成药物涂层。

公开(公告)号：US20090132031A1

公开(公告)日：2009-05-21

申请号：US11941591

申请日：2007-11-16

申请人： Brian Cook ,  Mark Dolan

发明人： Brian Cook ,  Mark Dolan

IPC分类号： A61F2/82

CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

摘要翻译： 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。