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公开(公告)号:US20110172174A1
公开(公告)日:2011-07-14
申请号:US11981279
申请日:2007-10-31
申请人: Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人: Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号: A61K31/166 , C07C259/04 , C07D207/16 , A61K31/40 , A61K31/165 , C07D265/30 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , C07D241/04 , A61K31/495 , C07D211/32 , A61K31/4453 , C07C275/64 , A61K31/17 , C07D401/04 , A61K31/55 , A61K31/7048 , A61P31/04
CPC分类号: C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要: Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号:US20100324025A1
公开(公告)日:2010-12-23
申请号:US12563697
申请日:2009-09-21
申请人: Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人: Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号: A61K31/55 , C07C259/06 , A61K31/16 , C07D295/155 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , A61K31/495 , C07D211/34 , A61K31/4453 , C07D207/27 , A61K31/40 , C07D207/16 , C07D401/06 , A61K31/4439 , C07D233/64 , A61K31/4164 , C07D217/26 , A61K31/472 , C07D241/04 , C07D401/04 , A61K31/4545 , C07D263/14 , A61K31/421 , C07D409/06 , A61K31/497 , A61K31/175 , C07C281/12 , C07C337/10 , C07D223/04 , C07D453/02 , A61K31/439 , C07D239/42 , A61K31/505 , C07D241/12 , A61K31/4965 , A61P31/04 , A61P11/00
CPC分类号: C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要: Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译: 提供式I的抗菌化合物:以及立体异构体,其药学上可接受的盐,酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号:US20080269221A1
公开(公告)日:2008-10-30
申请号:US11837327
申请日:2007-08-10
申请人: Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人: Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号: A61K31/5375 , C07C233/04 , A61K31/166 , C07D207/09 , A61P43/00 , A61K31/4015 , C07D265/30
CPC分类号: C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要: Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译: 提供式I的抗菌化合物:以及立体异构体,其药学上可接受的盐,酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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24.Eyeglass device with mechanical magnetic means for securing auxiliary lenses to eyeglass lenses 审中-公开
标题翻译: 具有用于将辅助镜片固定到眼镜镜片的机械磁性装置的眼镜装置公开(公告)号:US20050248720A1
公开(公告)日:2005-11-10
申请号:US10841169
申请日:2004-05-07
申请人: Simon Ng
发明人: Simon Ng
IPC分类号: G02C9/00
CPC分类号: G02C9/00 , G02C2200/02
摘要: The invention involves an eyeglass mountable auxiliary lens device. The present device attaches at least partially to the eyeglasses through magnetic interaction and provides among other things a close fitting and aesthetically pleasing union between the eyeglasses and the auxiliary frames.
摘要翻译: 本发明涉及一种可眼镜安装的辅助透镜装置。 本装置通过磁性相互作用至少部分地附着在眼镜上,并且在眼镜和辅助框架之间提供了紧密的和美观的联合。
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25.Eyeglass device with integral magnetic means for securing auxiliary lenses to eyeglass lenses 审中-公开
标题翻译: 具有集成磁性装置的眼镜装置,用于将辅助镜片固定在眼镜镜片上公开(公告)号:US20050062929A1
公开(公告)日:2005-03-24
申请号:US10670492
申请日:2003-09-24
申请人: Simon Ng
发明人: Simon Ng
IPC分类号: G02C9/00
CPC分类号: G02C9/00 , G02C2200/02
摘要: The invention involves an eyeglass mountable auxiliary lens device. The present device attaches at least partially to the eyeglasses through magnetic interaction and provides among other things a close fitting and aesthetically pleasing union between the eyeglasses and the auxiliary frames.
摘要翻译: 本发明涉及一种可眼镜安装的辅助透镜装置。 本装置通过磁性相互作用至少部分地附着在眼镜上,并且在眼镜和辅助框架之间提供了紧密的和美观的联合。
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公开(公告)号:US5605932A
公开(公告)日:1997-02-25
申请号:US582156
申请日:1996-01-02
IPC分类号: C07C271/24 , C07C323/32 , A61K31/185
CPC分类号: C07C271/24 , C07C323/32 , C07C2102/42
摘要: Compounds of Formula 1 bind opioid receptors: which binds to the opioid receptor: ##STR1##
摘要翻译: 式1的化合物结合阿片受体:其结合阿片受体:
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公开(公告)号:US5536868A
公开(公告)日:1996-07-16
申请号:US391132
申请日:1995-02-21
IPC分类号: C07C271/24 , C07C323/32 , C07C205/05 , C07C229/04 , C07C271/10
CPC分类号: C07C271/24 , C07C323/32 , C07C2102/42
摘要: Compounds of Formula 1 bind to the opioid receptors: ##STR1## wherein R.sub.1 is a group of the formula ##STR2## where W is --(CH.sub.2).sub.a -- (where a is 0, 1, or 2), --O--, --NH--, --S--, --SO--, or --SO.sub.2 --, and Ar is phenyl, phenyl-alkyl, phenyl substituted with 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups, and n is 0, 1, 2, 3, or 4;R.sub.2 and R.sub.3 are each independently H, lower alkyl, or ##STR3## where X is H, OH, lower alkyl, or lower alkoxy, and p is 0, 1, 2, or 3; R.sub.4 is ##STR4## where m is 0, 1, 2, or 3, and R is 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups;R.sub.5 is cycloalkyl, bicycloalkyl, or tricycloalkyl; andR.sub.6, R.sub.7, R.sub.8, and R.sub.9 are each independently H or lower alkyl.
摘要翻译: 式1的化合物与阿片受体结合:其中R 1是下式的基团:其中W是 - (CH 2)a - (其中a是0,1或2),-O-, - NH - , - S - , - SO-或-SO 2 - ,Ar是苯基,苯基 - 烷基,被1-3个卤素,硝基,低级烷基,羟基,氨基,烷基氨基,二烷基氨基和/或羟基 - 低级烷基,n为0,1,2,3或4; R 2和R 3各自独立地为H,低级烷基或者其中X为H,OH,低级烷基或低级烷氧基,p为0,1,2或3; R4是
,其中m是0,1,2或3,R是1-3个卤素,硝基,低级烷基,羟基,氨基,烷基氨基,二烷基氨基和/或羟基 - 低级烷基; R5是环烷基,双环烷基或三环烷基; 并且R 6,R 7,R 8和R 9各自独立地为H或低级烷基。 -
公开(公告)号:US07932262B2
公开(公告)日:2011-04-26
申请号:US12295967
申请日:2007-04-05
申请人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号: A61K31/517
CPC分类号: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要: The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译: 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物,以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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公开(公告)号:US20100048561A1
公开(公告)日:2010-02-25
申请号:US12295967
申请日:2007-04-05
申请人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人: Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号: A61K31/517 , C07D401/12 , C07D401/14 , C07D239/84 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要: The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译: 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物,以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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30.Self-assembled nanobump array stuctures and a method to fabricate such structures 失效
标题翻译: 自组装纳豆阵列结构和制造这种结构的方法公开(公告)号:US06853075B2
公开(公告)日:2005-02-08
申请号:US10353756
申请日:2003-01-28
申请人: Gregory W. Auner , Ratna Naik , Simon Ng , Gary W. Abrams , James Patrick McCallister , Raymond Iezzi
发明人: Gregory W. Auner , Ratna Naik , Simon Ng , Gary W. Abrams , James Patrick McCallister , Raymond Iezzi
IPC分类号: B23K35/36 , G01N29/02 , G01N29/24 , G01N29/34 , G11B5/855 , H01F1/00 , H01L21/20 , H01L21/205 , H01L21/44 , H01L23/48 , H01L31/00 , H01L51/00 , H01L51/10
CPC分类号: B23K35/36 , A61F9/08 , A61F2002/30701 , A61F2002/3084 , A61F2002/3097 , B82Y10/00 , B82Y25/00 , G11B5/855 , H01F1/009 , H01L21/0237 , H01L21/02378 , H01L21/0242 , H01L21/02491 , H01L21/0254 , H01L21/0259 , H01L21/02631 , H01L51/0595 , H01L51/102 , Y10S977/816 , Y10S977/889
摘要: A self-assembled nanobump array structure including a semi-absorbing outer layer provided on at least one nanobump-forming substrate layer, the semi-absorbing outer layer configured to ablate slowly to allow an applied laser energy to be transmitted to the at least one nanobump-forming substrate layer, in which the self-assembled nanobump array structure is formed by an energy and a pressure buildup occurring in the at least one nanobump-forming substrate layer.
摘要翻译: 一种自组装纳豆块阵列结构,包括设置在至少一个纳米块形成衬底层上的半吸收外层,所述半吸收外层被配置为缓慢烧蚀以允许所施加的激光能量传递到所述至少一个纳米块 其中通过在所述至少一个纳米块形成衬底层中发生的能量和压力积聚形成所述自组装纳豆块阵列结构。
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