Modified siphons for improved metering precision
    21.
    发明授权
    Modified siphons for improved metering precision 失效
    改进的虹吸管,以提高计量精度

    公开(公告)号:US06235531B1

    公开(公告)日:2001-05-22

    申请号:US08562327

    申请日:1995-11-22

    IPC分类号: G01N3500

    摘要: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors include siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.

    摘要翻译: 本发明提供了用于将预先测量的体积的液体输送到转子中的室的离心转子。 特别地,转子包括用于在转子中的第一和第二室之间输送预先测量的液体体积的虹吸管。 本发明的虹吸设计成使得第一室上的虹吸入口在第二室上的虹吸出口的径向外侧。 第一个室被排空到与虹吸出口的径向位置相当的水平。

    Indicator detection using transverse emissions
    25.
    发明申请
    Indicator detection using transverse emissions 有权
    使用横向排放的指标检测

    公开(公告)号:US20080180673A1

    公开(公告)日:2008-07-31

    申请号:US11701292

    申请日:2007-01-31

    IPC分类号: G01N21/75

    摘要: A test system includes an optical medium, a binding agent capable of capturing a target complex, and a light detector. The optical medium provides a light path, and the binding agent is positioned to hold the target complex in an evanescent field created by propagation of light along the light path. The complex interacts with the evanescent field and emits light that the detector positioned to detect. The optical medium and the detector can be included in an optical integrated circuit where detected light passes through the optical medium transverse to the direction of the light path.

    摘要翻译: 测试系统包括光学介质,能够捕获目标复合物的粘合剂和光检测器。 光学介质提供光路,并且粘合剂被定位成将目标复合体保持在通过沿着光路的光的传播产生的消逝场中。 复合体与ev逝场相互作用并发射检测器定位以检测的光。 光学介质和检测器可以包括在光学集成电路中,其中检测到的光穿过光学介质横向于光路的方向。

    Arrays and their reading
    28.
    发明授权
    Arrays and their reading 失效
    数组和他们的阅读

    公开(公告)号:US06864097B1

    公开(公告)日:2005-03-08

    申请号:US09671966

    申请日:2000-09-27

    摘要: A method of reading an array of moieties such as polynucleotides (for example, DNA) on at least a portion of a surface of a transparent slide which is opposite a first portion on the opposing surface, which array has been previously exposed to a sample. The method may include mounting the slide on a slide holder and retaining the slide thereon in a mounted position in which the holder does not contact the previously exposed array. The holder is then inserted into an array reader and the array read. A holder and slides which can be used in the method are also provided.

    摘要翻译: 在透明载体的至少一部分表面上读取诸如多核苷酸(例如DNA)的阵列阵列的方法,其与相对表面上的第一部分相对,该阵列已经预先暴露于样品。 该方法可以包括将滑块安装在滑动架上并将滑动件保持在安装位置,在安装位置,保持器不接触先前暴露的阵列。 然后将支架插入阵列读取器并读取阵列。 还提供了可以在该方法中使用的保持器和载玻片。

    Modified siphons for improving metering precision
    29.
    发明授权
    Modified siphons for improving metering precision 有权
    改进的虹吸管,以提高计量精度

    公开(公告)号:US06752961B2

    公开(公告)日:2004-06-22

    申请号:US09834300

    申请日:2001-04-12

    IPC分类号: G01N930

    摘要: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.

    摘要翻译: 本发明提供了用于将预先测量的体积的液体输送到转子中的室的离心转子。 特别地,转子包括用于在转子中的第一和第二室之间递送预先测量的液体体积的虹吸管。 本发明的虹吸设计成使得第一室上的虹吸入口在第二室上的虹吸出口的径向外侧。 第一个室被排空到与虹吸出口的径向位置相当的水平。

    Methods and compositions for producing biopolymeric arrays
    30.
    发明授权
    Methods and compositions for producing biopolymeric arrays 失效
    用于生产生物聚合物阵列的方法和组合物

    公开(公告)号:US06346423B1

    公开(公告)日:2002-02-12

    申请号:US09354816

    申请日:1999-07-16

    申请人: Carol T. Schembri

    发明人: Carol T. Schembri

    IPC分类号: G01N33543

    摘要: Methods and compositions are provided for producing arrays of polymeric binding agents. In the subject methods, the individual polymers of the array are synthesized using solid phase synthesis techniques on the surface of a substrate. A critical feature of the invention is that one or more locations on the substrate surface are spatially and temporally protected by a protective bubble during the synthesis protocol, where the protective bubble may be produced using any convenient bubble producing means. The bubble producing means may be a component of either a substrate or a structure separate from the substrate. Also provided are the arrays produced by the subject methods, kits for use in practicing the subject methods, and methods of using the arrays in analyte detection assays, including hybridization assays, such as gene discovery, differential gene expression and gene sequencing assays.

    摘要翻译: 提供了用于生产聚合物粘合剂阵列的方法和组合物。 在本发明的方法中,使用固相合成技术在基材表面上合成阵列的单个聚合物。 本发明的关键特征是在合成方案期间,衬底表面上的一个或多个位置在空间和时间上被保护气泡保护,其中使用任何便利的气泡产生装置可以产生保护气泡。 气泡产生装置可以是衬底或与衬底分离的结构的部件。 还提供了通过主题方法产生的阵列,用于实践主题方法的试剂盒以及在分析物检测测定中使用阵列的方法,包括杂交测定,例如基因发现,差异基因表达和基因测序测定。