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    Systems and methods for collision induced dissociation of ions in an ion trap
    21.
    发明授权
    Systems and methods for collision induced dissociation of ions in an ion trap 有权

    公开(公告)号：US10923336B2

    公开(公告)日：2021-02-16

    申请号：US16073255

    申请日：2017-04-06

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Dalton Snyder

    IPC: H01J49/42 ,  H01J49/00

    Abstract: The invention generally relates to systems and methods for collision induced dissociation of ions in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to generate one or more signals, and apply the one or more signals to the ion trap in a manner that all ions within the ion trap are fragmented at a same Mathieu q value.

    Mass spectrometry analysis of microorganisms in samples
    22.
    发明授权
    Mass spectrometry analysis of microorganisms in samples 有权

    公开(公告)号：US10811241B2

    公开(公告)日：2020-10-20

    申请号：US16809171

    申请日：2020-03-04

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

    IPC: H01J49/04 ,  C12N13/00 ,  C12Q1/04 ,  H01J49/16

    Abstract: The invention generally relates to methods for analyzing an analyte in a sample. In certain embodiments, the methods involve providing a capture module, the module configured to capture an analyte in a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source, and wherein the porous substrate further comprises an internal standard; capturing the analyte in the sample to the porous substrate of the capture module; generating ions of the analyte and the internal standard held by the porous substrate via the voltage source that is coupled to the porous substrate; and analyzing the generated ions of the analyte and the internal standard in a mass analyzer that is operably coupled to the capture module.

    Zero voltage mass spectrometry probes and systems
    23.
    发明授权
    Zero voltage mass spectrometry probes and systems 有权

    公开(公告)号：US10714323B2

    公开(公告)日：2020-07-14

    申请号：US16280319

    申请日：2019-02-20

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  Soumabha Bag ,  Yafeng Li

    IPC: H01J49/04 ,  H01J49/00

    Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.

    ION FOCUSING
    24.
    发明申请
    ION FOCUSING 审中-公开

    公开(公告)号：US20200219711A1

    公开(公告)日：2020-07-09

    申请号：US16803023

    申请日：2020-02-27

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT
    27.
    发明申请
    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开

    公开(公告)号：US20190219555A1

    公开(公告)日：2019-07-18

    申请号：US16245703

    申请日：2019-01-11

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Roy Helmy ,  Yangjie Li ,  Yong Liu

    IPC: G01N33/15 ,  H01J49/00 ,  H01J49/04

    CPC classification number: G01N33/15 ,  H01J49/0027 ,  H01J49/0445

    Abstract: The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.

    ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN
    28.
    发明申请
    ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN 审中-公开

    公开(公告)号：US20190057856A1

    公开(公告)日：2019-02-21

    申请号：US15769998

    申请日：2016-10-21

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Jason Duncan ,  Joshua Wiley

    IPC: H01J49/42 ,  H01J49/00

    Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

    Ion focusing
    30.
    发明授权
    Ion focusing 有权

    公开(公告)号：US10014169B2

    公开(公告)日：2018-07-03

    申请号：US15407499

    申请日：2017-01-17

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/26 ,  H01J49/10 ,  H01J49/16

    CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

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