公开(公告)号：US20100040766A1

公开(公告)日：2010-02-18

申请号：US12583112

申请日：2009-08-14

申请人： Ralph A. Chappa ,  Mark F. Carlson

发明人： Ralph A. Chappa ,  Mark F. Carlson

IPC分类号： B05D7/00 ,  B05B1/00

CPC分类号： A61M25/1029 ,  A61M25/1018 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0214 ,  B05B13/0228 ,  B05C13/00 ,  B05D1/002 ,  B05D1/02 ,  B05D3/12

摘要： A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.

摘要翻译： 描述了一种用于涂覆球囊导管的球囊部分的涂覆装置。 涂覆装置包括可旋转构件，其中气囊导管的导管部分被安装和固定，并且引起气囊导管的旋转。 该装置还包括支撑构件，其中导管的远侧末端插入并自由旋转; 以及将喷射材料引导到气球表面上的喷嘴。 涂覆装置的本发明构造允许球囊导管沿着其轴线旋转，具有非实质或无摆动，这显着地改善了施加到气球表面的涂层的质量。

公开(公告)号：US20090269481A1

公开(公告)日：2009-10-29

申请号：US12109139

申请日：2008-04-24

申请人： Ralph A. Chappa ,  James H. Arps

发明人： Ralph A. Chappa ,  James H. Arps

IPC分类号： B05B13/02

CPC分类号： A61F2/82 ,  A61F2240/001 ,  B05B13/0242 ,  B05B13/0442

摘要： The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

摘要翻译： 本发明涉及将涂料涂覆到装置上的系统和方法。 在一个实施例中，本发明包括涂覆设备，其包括具有纵向轴线和外表面的心轴，心轴的外表面限定平行于纵向轴线设置的多个通道，心轴构造成围绕纵向轴线旋转; 以及喷头，其配置成在心轴处引导材料流。 在一个实施方案中，本发明包括将涂层施加到医疗装置的方法。 本文还包括其它实施例。

公开(公告)号：USRE40722E1

公开(公告)日：2009-06-09

申请号：US11823055

申请日：2007-06-26

申请人： Ralph A. Chappa

发明人： Ralph A. Chappa

IPC分类号： A61L33/00 ,  B05D1/02

CPC分类号： B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

摘要： The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.

摘要翻译： 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

公开(公告)号：US06254634B1

公开(公告)日：2001-07-03

申请号：US09095371

申请日：1998-06-10

申请人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

发明人： Aron B. Anderson ,  Ralph A. Chappa ,  Terrence P. Everson

IPC分类号： A61F206

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  Y10S623/901 ,  C08L83/04

摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

摘要翻译： 支撑材料形式的制品（例如，可植入医疗制品的形式），该支撑材料具有由功能性硅氧烷聚合物制剂组成的中间层，该中间层在其上具有光固化性的目标化合物。 在另一方面，一种制造制品的方法，包括以下步骤：提供支撑材料，施加中间层并将目标化合物光固化到中间层上，以及任选地将载体材料重整成最终期望的制品。

公开(公告)号：US09427501B2

公开(公告)日：2016-08-30

申请号：US12636164

申请日：2009-12-11

申请人： Ralph A. Chappa ,  Kimberly K. M. Lindsoe

发明人： Ralph A. Chappa ,  Kimberly K. M. Lindsoe

IPC分类号： A61K47/32 ,  A61K31/56 ,  A61L31/16 ,  A61K6/00 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

摘要： Coatings with crystallized active agent(s) and related methods are disclosed. One method includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. Also disclosed is an elution control coating which includes an active agent that is at least about 80% crystallized within one week of being disposed on a medical device. One method enhances the formation of active agent crystals within a coating layer by adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. Another method includes increasing the rate of active agent nucleation within the coating.

摘要翻译： 公开了具有结晶活性剂的涂层和相关方法。 一种方法包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物，以及将涂料组合物施用于医疗装置。 还公开了一种洗脱控制涂层，其包括活性剂，其在置于医疗装置上一周内至少约80％结晶。 一种方法通过调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比来增强涂层内活性剂晶体的形成。 另一种方法包括增加涂层内的活性剂成核速率。

公开(公告)号：US20100240789A1

公开(公告)日：2010-09-23

申请号：US12783907

申请日：2010-05-20

申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC分类号： C08F2/46

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

公开(公告)号：US07776382B2

公开(公告)日：2010-08-17

申请号：US11388478

申请日：2006-03-24

申请人： Ralph A. Chappa ,  Mark F. Carlson

发明人： Ralph A. Chappa ,  Mark F. Carlson

IPC分类号： B05D1/02 ,  B05D1/40 ,  B05C13/00 ,  B05B13/04

CPC分类号： B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

摘要： A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

摘要翻译： 描述了一种包括具有一对辊和喷嘴的装置旋转器的可卷绕装置的方法。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

公开(公告)号：US20100018602A1

公开(公告)日：2010-01-28

申请号：US12507865

申请日：2009-07-23

申请人： Ralph A. Chappa

发明人： Ralph A. Chappa

IPC分类号： B65B3/12

CPC分类号： B65B3/003 ,  A61F9/0017 ,  A61F2250/0068

摘要： The invention relates to systems and methods for filling a medical device with an active agent composition. In an embodiment, the invention includes a method for filling a medical device with an active agent composition. The method can include applying the active agent composition to the outside surface of the medical device, the medical device comprising a housing defining a lumen and a plurality of apertures. The method can also include contacting a surface of a press member against the outside surface of the medical device thereby pushing the active agent composition through the apertures and into the lumen of the medical device. Other embodiments are also included herein.

摘要翻译： 本发明涉及用活性剂组合物填充医疗装置的系统和方法。 在一个实施方案中，本发明包括用活性剂组合物填充医疗装置的方法。 该方法可以包括将活性剂组合物施加到医疗装置的外表面，医疗装置包括限定内腔和多个孔的壳体。 该方法还可以包括将压力构件的表面接触医疗装置的外表面，从而将活性剂组合物通过孔推入并进入医疗装置的内腔。 本文还包括其它实施例。

公开(公告)号：US07575781B2

公开(公告)日：2009-08-18

申请号：US10911228

申请日：2004-08-03

申请人： Ralph A. Chappa

发明人： Ralph A. Chappa

IPC分类号： C23C16/00 ,  A61L33/04

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/60 ,  B05D3/0218 ,  B05D2202/15 ,  C08L65/04

摘要： The present application relates to a method for vapor depositing a polymeric coating onto a substrate. In an embodiment, the invention is a method for applying a polymer coating to a substrate comprising performing a bake-out cycle with a chemical vapor deposition system and performing a deposition cycle with the chemical vapor deposition system.

摘要翻译： 本申请涉及将聚合物涂层气相沉积到基底上的方法。 在一个实施方案中，本发明是一种将聚合物涂层施加到基底上的方法，包括用化学气相沉积系统执行烘烤循环并且与化学气相沉积系统一起进行沉积循环。

公开(公告)号：US06669994B2

公开(公告)日：2003-12-30

申请号：US09840406

申请日：2001-04-23

申请人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

发明人： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC分类号： C08F248

CPC分类号： C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.