公开(公告)号：US07202342B1

公开(公告)日：2007-04-10

申请号：US09570737

申请日：2000-05-12

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20060088527A1

公开(公告)日：2006-04-27

申请号：US11301554

申请日：2005-12-13

申请人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

发明人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/06 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06699664B1

公开(公告)日：2004-03-02

申请号：US09667857

申请日：2000-09-20

申请人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

发明人： Jennifer L. Mitcham ,  Gordon E. King ,  Paul A. Algate ,  Steven P. Fling ,  Marc W. Retter ,  Gary R. Fanger ,  Steven G. Reed ,  Thomas S. Vedvick ,  Darrick Carter

IPC分类号： C12Q168

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。

公开(公告)号：US20050260177A1

公开(公告)日：2005-11-24

申请号：US11108172

申请日：2005-04-15

申请人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

发明人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

IPC分类号： A61K31/7088 ,  A61K45/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/3046 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US20060269532A1

公开(公告)日：2006-11-30

申请号：US11344932

申请日：2006-02-01

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20140037691A1

公开(公告)日：2014-02-06

申请号：US13930953

申请日：2013-06-28

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US20120039994A1

公开(公告)日：2012-02-16

申请号：US13277919

申请日：2011-10-20

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K9/127

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

公开(公告)号：US08062783B2

公开(公告)日：2011-11-22

申请号：US11947667

申请日：2007-11-29

申请人： Darrick Carter ,  Joshua K. Hoyt ,  James Thorne ,  Forrest Seitz

发明人： Darrick Carter ,  Joshua K. Hoyt ,  James Thorne ,  Forrest Seitz

IPC分类号： H01M6/00 ,  A61N1/30 ,  H01F7/20

CPC分类号： A61N1/303 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/306 ,  A61N1/325 ,  H01M2/1038 ,  H01M10/42 ,  H01M10/4257 ,  H01M2200/00 ,  H02J5/005 ,  H02J7/025 ,  H02J50/05 ,  H02J50/10

摘要： Systems, devices, and methods for powering and/or controlling electrically powered devices. A power supply system is operable to provide a voltage across at the active and the counter electrode assemblies of a transdermal delivery device. The system includes a power source and a magnetic coupling element.

摘要翻译： 用于为电力设备供电和/或控制的系统，设备和方法。 电源系统可操作以在透皮递送装置的活性和对电极组件处提供电压。 该系统包括电源和磁耦合元件。

公开(公告)号：US20070213652A1

公开(公告)日：2007-09-13

申请号：US11617609

申请日：2006-12-28

申请人： Darrick Carter

发明人： Darrick Carter

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/37252 ,  G06F19/3418 ,  G06F19/3456 ,  H04L9/32 ,  H04L63/0428 ,  H04L63/10 ,  H04L2209/88

摘要： The present invention comprises an active agent reservoir that stores a quantity of an active agent, an active electrode element operable to apply an electrical potential of a first polarity to deliver at least a portion of the active agent to a biological interface from the iontophoresis device, and a communications port providing a communications path between the iontophoresis device and a remote device. A method of the invention comprises operating an interface system to remotely interact with iontophoresis devices useful in delivery of active agents to biological interfaces including providing a user interface at a location remote from at least some of the iontophoresis devices, communicating with at least two of the iontophoresis devices, and providing information about the iontophoresis devices via the user interface.

摘要翻译： 本发明包括存储一定量的活性剂的活性剂储存器，可操作以施加第一极性的电势以将至少一部分活性剂递送至离子电渗疗法装置的生物界面的活性电极元件， 以及提供离子渗透装置和远程装置之间的通信路径的通信端口。 本发明的方法包括操作界面系统以远程与离子电渗装置相互作用，所述离子电渗装置可用于将活性剂递送到生物界面，包括在远离至少一些离子渗透装置的位置提供用户界面，与至少两个 离子渗透装置，以及通过用户界面提供关于离子电渗装置的信息。

公开(公告)号：US08722064B2

公开(公告)日：2014-05-13

申请号：US12794336

申请日：2010-06-04

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/00 ,  A61K31/70 ,  C07H15/00

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K31/665 ,  A61K31/7016 ,  A61K39/00 ,  A61K39/04 ,  A61K39/21 ,  A61K39/235 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/525 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  C07H15/04 ,  C07H15/12 ,  C07H15/20

摘要： Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.

摘要翻译： 提供具有以下结构（I）的化合物，特别是具有下列结构（I）的吡喃葡萄糖基脂质佐剂（GLA）化合物或其药学上可接受的盐，其中L1，L2，L3，L4，L5，L6，L7，L8，L9，L10， Y1，Y2，Y3，Y4，R1，R2，R3，R4，R5，R6如本文所定义。 还提供了用于诱导或增强免疫应答的药物组合物，疫苗组合物和相关方法。