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139 条记录 (耗时 0.047 秒)

    Direct, externally imposed control of polypeptides
    22.
    发明授权
    Direct, externally imposed control of polypeptides 失效
    直接的外部控制多肽

    公开(公告)号：US06953656B2

    公开(公告)日：2005-10-11

    申请号：US09905831

    申请日：2001-07-13

    申请人： Joseph M. Jacobson ,  John J. Schwartz ,  Kimberly Hamad ,  Shuguang Zhang

    发明人： Joseph M. Jacobson ,  John J. Schwartz ,  Kimberly Hamad ,  Shuguang Zhang

    IPC分类号： C07K14/47 ,  C12N13/00 ,  C12Q1/00 ,  C12Q1/18

    CPC分类号： C12N13/00 ,  C07K14/47 ,  C12N2310/351 ,  C12N2310/53 ,  Y10S204/904

    摘要： Methods and compositions for rendering proteins directly responsive to an external signal utilizing modulators that themselves respond to the external signal and are associated with the proteins. In response to the external signal, the modulator alters physical properties of the specific protein molecule(s) with which it is associated, thereby altering the structural and functional properties thereof. The modulator may, for example, transfer applied energy to a protein, or to a portion of the protein, thereby changing the protein structure and function.

    摘要翻译： 使用本身对外部信号响应并与蛋白质相关的调节剂使蛋白质直接响应于外部信号的方法和组合物。 响应于外部信号，调节剂改变与其相关联的特定蛋白质分子的物理性质，从而改变其结构和功能性质。 调节剂可以例如将施加的能量转移到蛋白质或蛋白质的一部分，从而改变蛋白质结构和功能。

    Oscillating fiber optic display and imager
    27.
    发明授权
    Oscillating fiber optic display and imager 失效
    振荡光纤显示器和成像器

    公开(公告)号：US5727098A

    公开(公告)日：1998-03-10

    申请号：US369695

    申请日：1995-01-06

    申请人： Joseph M. Jacobson

    发明人： Joseph M. Jacobson

    IPC分类号： G02B6/35 ,  G02B6/42 ,  G02B26/10 ,  G02B27/00 ,  G02B27/01 ,  G02B6/26

    CPC分类号： G02B27/017 ,  G02B26/10 ,  G02B26/103 ,  G02B2027/0138 ,  G02B6/3502 ,  G02B6/3572 ,  G02B6/3578 ,  G02B6/4226

    摘要： A display system includes an image light source for producing a modulated light, an optical fiber having a first end and a second end, the first end of the optical fiber being coupled to the light source, and a deflation device coupled to the second end of the optical fiber, the deflection device deflecting the second end of the optical fiber in a two-dimensional scan pattern for projecting an image onto a viewing surface from the second end of the optical fiber, wherein the projected image is related to the modulated light.

    摘要翻译： 显示系统包括用于产生调制光的图像光源，具有第一端和第二端的光纤，光纤的第一端耦合到光源，以及联接到第二端的放气装置 光纤，偏转装置以二维扫描图案偏转光纤的第二端，用于将图像从光纤的第二端投影到观察表面上，其中投影图像与调制光有关。

    Programmable Modification of DNA
    28.
    发明申请
    Programmable Modification of DNA 审中-公开
    可编程修饰DNA

    公开(公告)号：US20140349400A1

    公开(公告)日：2014-11-27

    申请号：US14217426

    申请日：2014-03-17

    申请人： Noah Jakimo ,  Peter A. Carr ,  Joseph M. Jacobson

    发明人： Noah Jakimo ,  Peter A. Carr ,  Joseph M. Jacobson

    IPC分类号： C12N15/63

    CPC分类号： C12N15/635 ,  C12N15/102

    摘要： A self-reconfiguring genome uses a cassette having operons or DNA sequences that code for guide RNA, reverse transcriptase, donor RNA, and a CRISPR cleavage enzyme. A self-reconfiguring genome may be based on lambda recombineering of in situ generated oligonucleotides. A method for programmable self-modification of a cellular genome includes transcribing guide RNA from a self-reconfiguring cassette, associating the transcribed guideRNA with the CRISPR enzyme, intercalcating a region of complimentary sequence within an integration site of the genome, cutting upstream of a PAM site within the integration site; transcribing the donorRNA, translating donorRNA to double-stranded DNA, and recombining the double-stranded DNA via homologous recombination at the cut site of the integration site. A set of cascadable and multiplexable genetic logic gates with a universal RNA input/output based on single-strand annealing or non-homologous end joining, comprises transcription promoters or terminators, homologous regions, DNA sequences, RNA, and enzymes from the CRISPR system.

    摘要翻译： 自重构基因组使用具有编码引导RNA，逆转录酶，供体RNA和CRISPR切割酶的操纵子或DNA序列的盒。 自重构基因组可以基于原位产生的寡核苷酸的λ重组。 用于细胞基因组的可编程自修饰的方法包括从自重构盒转录引导RNA，将转录的引导RNA与CRISPR酶缔合，在基因组的整合位点嵌入互补序列的区域，切割PAM的上游 整合网站内的网站; 转录供体RNA，将供体RNA翻译成双链DNA，并通过同源重组在整合位点的切割位点重组双链DNA。 一组具有基于单链退火或非同源末端连接的通用RNA输入/输出的可级联和可复用的遗传逻辑门包括来自CRISPR系统的转录启动子或终止子，同源区，DNA序列，RNA和酶。

    Templated Monolayer Polymerization and Replication
    29.
    发明申请
    Templated Monolayer Polymerization and Replication 审中-公开
    模板单层聚合和复制

    公开(公告)号：US20130280920A1

    公开(公告)日：2013-10-24

    申请号：US13919185

    申请日：2013-06-17

    申请人： Joseph M. Jacobson ,  David W. Mosley

    发明人： Joseph M. Jacobson ,  David W. Mosley

    IPC分类号： H01L21/02 ,  H01L21/283

    CPC分类号： H01L21/02112 ,  B05D1/185 ,  B82Y30/00 ,  B82Y40/00 ,  G01N31/22 ,  G03F7/165 ,  H01L21/283 ,  Y10S977/882 ,  Y10S977/883

    摘要： A self-replicating monolayer system employing polymerization of monomers or nanoparticle ensembles on a defined template provides synthesis of two-dimensional single molecule polymers. Systems of self-replicating monolayers are used as templates for growth of inorganic colloids. A preferred embodiment employs SAM-based replication, wherein an initial monolayer is patterned and used as a template for self-assembly of a second monolayer by molecular recognition. The second monolayer is polymerized in place and the monolayers are separated to form a replicate. Both may then function as templates for monolayer assemblies. A generic self-replicating monomer unit comprises a polymerizable moiety attached by methylene repeats to a recognition element and an ending unit that will not interfere with the chosen recognition chemistry. The recognition element is self-complementary, unless two replicating monomers with compatible cross-linking chemistry are employed. After replication, selective mineralization and/or electroless plating may produce a two-dimensional inorganic sheet having patterned domains within it.

    摘要翻译： 使用单体或纳米颗粒合成体在定义的模板上进行聚合的自复制单层体系提供二维单分子聚合物的合成。 自复制单层系统用作无机胶体生长的模板。 优选的实施方案采用基于SAM的复制，其中初始单层被图案化并用作通过分子识别自组装第二单层的模板。 将第二单层聚合就位，并将单层分离形成复制物。 然后两者都可以作为单层组件的模板。 一般的自复制单体单元包括通过亚甲基重复序列连接到识别元件的可聚合部分和不会干扰所选择的识别化学物质的结束单元。 识别元件是自互补的，除非使用具有相容的交联化学的两种复制单体。 复制后，选择性矿化和/或化学镀可以产生其内具有图案区的二维无机片。

    Nanoparticle chains by direct bonding of functional groups and preparation thereof
    30.
    发明授权
    Nanoparticle chains by direct bonding of functional groups and preparation thereof 有权
    通过官能团的直接键合制备纳米粒子链

    公开(公告)号：US08563081B2

    公开(公告)日：2013-10-22

    申请号：US13747373

    申请日：2013-01-22

    申请人： Joseph M. Jacobson ,  David W. Mosley ,  Kie-Moon Sung

    发明人： Joseph M. Jacobson ,  David W. Mosley ,  Kie-Moon Sung

    IPC分类号： B32B5/16 ,  B05D1/00 ,  B05D7/00 ,  C01B13/00

    CPC分类号： C08B37/0012 ,  B05D1/00 ,  C01B13/00 ,  C08B37/0015 ,  Y10S977/778 ,  Y10S977/882 ,  Y10T428/25 ,  Y10T428/2991

    摘要： Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.

    摘要翻译： 通过连续的化学反应来实现纳米颗粒到一维线性链中的制备和排列，每个反应通过构建到暴露的未受保护的接头功能上而添加一种或多种纳米颗粒。 任选地，保护基团可用于控制和组织生长。 纳米颗粒球以受控的方式进行功能化，以实现共价键。 纳米颗粒的官能化通过配体交换或封端配体的末端官能团的化学修饰来实现。 通过各种连接模式（例如直接偶联，使用连接分子）和使用线性聚合物模板获得纳米颗粒链。 特别地，通过纳米颗粒的受控单官能化获得通用的结构单元体系。