Infection-resistant materials and method of making same through use of
sulfonamides
    24.
    发明授权
    Infection-resistant materials and method of making same through use of sulfonamides 失效
    抗感染材料及其制备方法通过使用磺酰胺

    公开(公告)号:US4581028A

    公开(公告)日:1986-04-08

    申请号:US605793

    申请日:1984-04-30

    Abstract: Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.

    Abstract translation: 感染抗性材料及其制备方法,适合在人体或动物体内部以血管移植假体或其它植入装置的形式使用。 通过加入其中的抗微生物剂,例如磺酰胺的金属盐和其他抗微生物剂或抗菌剂如哌拉西林,使该物质变得具有抗感染性。 在具体的示例性实施方案中,磺胺嘧啶银通过具有天然或合成聚合材料如丝,聚酯(例如,涤纶),聚氨酯,聚四氟乙烯或硅氧烷基材料的新技术络合,以提供长期预防可能的感染 结果在手术或植入装置期间或之后。

    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids
    25.
    发明申请
    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids 审中-公开
    包含抗感染化合物,辛氧基甘油,水杨酸和倍半萜烯的组合的抗菌药物

    公开(公告)号:US20060099237A1

    公开(公告)日:2006-05-11

    申请号:US11250241

    申请日:2005-10-14

    Abstract: Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber. Antimicrobial compositions comprising salicylic acid and sesquiterpenoids are also disclosed.

    Abstract translation: 公开了用含有辛氧基甘油和其它抗感染化合物的协同组合的抗微生物组合物浸渍的医疗制品。 这样的医疗制品可以包括导尿管,中心静脉导管,气管导管,动脉移植物,伤口敷料,缝合线或衍生自聚合物基底的生物医学聚氨酯,生物医学聚氯乙烯(PVC),生物医学硅,生物可降解聚合物,聚四氟乙烯 (PTFE)等,或天然橡胶,丝绸或棉纤维等天然产品。 还公开了包含水杨酸和倍半萜类化合物的抗微生物组合物。

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