公开(公告)号：US20180292362A1

公开(公告)日：2018-10-11

申请号：US15948653

申请日：2018-04-09

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  Joshua A. Shreve ,  Jason F. Hill ,  Abhijit Tarafder ,  Michael O. Fogwill ,  Keith Fadgen

IPC: G01N30/38 ,  B01D15/40 ,  B01D15/16 ,  G01N30/46 ,  G01N30/32

Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.

公开(公告)号：US20130134083A1

公开(公告)日：2013-05-30

申请号：US13749929

申请日：2013-01-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

IPC: B01D15/14

CPC classification number: B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Abstract translation: 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内部导管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。

公开(公告)号：US12259369B2

公开(公告)日：2025-03-25

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  B01D15/16 ,  B01D15/22 ,  B01D15/38 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  G01N1/40 ,  G01N30/00 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US12247962B2

公开(公告)日：2025-03-11

申请号：US17057242

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/60 ,  G01N30/00 ,  G01N30/06

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：US20220226750A1

公开(公告)日：2022-07-21

申请号：US17716367

申请日：2022-04-08

Applicant: Waters Technologies Corporation

Inventor： Zongren Shang ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Michael Eggertson ,  Keith Fadgen

IPC: B01D15/16 ,  G01N30/32

Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.

公开(公告)号：US11275061B2

公开(公告)日：2022-03-15

申请号：US16545590

申请日：2019-08-20

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Keith Fadgen ,  Joseph D. Michienzi ,  Stanislaw Koziol

IPC: G01N30/16 ,  G01N30/20 ,  G01N30/32 ,  G01N30/02

Abstract: Described is a fluidic manifold that includes a block formed of multiple layers each bonded to at least one adjacent layer at a layer interface. Bonding may be achieved using a diffusion bonding process. The block includes one or more attachment surfaces and at least two fluidic channels. Each fluidic channel is at least partially disposed at one of the layer interfaces and has a first end at one of the attachment surfaces. Each attachment surface includes an attachment feature at the first end of one of the fluidic channels to enable a fluidic coupling of the two fluidic channels through a fluidic component. Attachment features include, for example, a compression fitting coupling body adapted to receive a conventional seal, such as a ferrule and compression screw, and a fitting body that permits a face seal or gasket seal between the fluidic component and the block.

公开(公告)号：US20210123891A1

公开(公告)日：2021-04-29

申请号：US17143814

申请日：2021-01-07

Applicant: Waters Technologies Corporation

Inventor： Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

IPC: G01N30/34 ,  G01N30/32 ,  G05D11/13

Abstract: A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

公开(公告)号：US20190234915A1

公开(公告)日：2019-08-01

申请号：US16382083

申请日：2019-04-11

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Keith Fadgen ,  Joseph D. Michienzi ,  Bernard Bunner

IPC: G01N30/38 ,  B01L3/00 ,  F04D15/00 ,  F04D29/08 ,  G01N30/20 ,  F16K99/00

CPC classification number: G01N30/38 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0689 ,  B01L2400/0622 ,  B01L2400/0644 ,  F04D15/00 ,  F04D29/086 ,  F16K99/0013 ,  G01N30/20 ,  G01N2030/202

Abstract: A method may include reducing fluid flow between a rotor and a microfluidic device. The method may further include reducing a sealing force between the rotor and the microfluidic device. The method may also include rotating the rotor relative to the microfluidic device, at the reduced sealing force, to change a fluid pathway therebetween. The method may additionally include reestablishing the sealing force to produce a fluid tight seal between the rotor and the microfluidic device. Moreover, the method may include reestablishing the fluid flow between the rotor and the microfluidic device.

公开(公告)号：US20180306760A1

公开(公告)日：2018-10-25

申请号：US15990097

申请日：2018-05-25

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille ,  Raymond P. Fisk ,  Frank John Marzalkowski, JR.

IPC: G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B05B5/16 ,  B01D15/18 ,  G01N30/72

Abstract: Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit. The outer tube is deformed by a first uniform radial crimp at a longitudinal location along the outer tube that surrounds the first conduit on a first side of the first joint, and a second uniform radial cramp at a longitudinal location along the outer tube that surrounds the second conduit on a second side of the first joint. The first and second uniform radial cramps form a fluid-tight seal between the first conduit and the second conduit and each have a substantially flat base region over which a diameter of the outer tube is reduced for a non-zero longitudinal length.

公开(公告)号：US10071374B2

公开(公告)日：2018-09-11

申请号：US14904135

申请日：2014-08-04

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  James P. Murphy ,  Michael O. Fogwill ,  Keith Fadgen ,  Geoff Gerhardt ,  Gary W. Bertone

IPC: B01D1/02 ,  B01L3/00 ,  B01L7/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894

Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.