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21.发明授权
公开(公告)号：US4855323A
公开(公告)日：1989-08-08
申请号：US223129
申请日：1988-07-22
IPC分类号： A61K31/38 , A61K31/085 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D333/16
CPC分类号： C07D317/36 , A61K31/10 , A61K31/215 , C07C323/00
摘要： Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
摘要翻译： 白细胞三烯拮抗剂，其制备方法及其用于治疗其中R1，R2，R3，R4，R5和X具有指定含义的疾病的用途，其制备方法 化合物，其作为药物的用途，以及基于这些化合物的药物。
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公开(公告)号：US5204351A
公开(公告)日：1993-04-20
申请号：US389809
申请日：1989-08-04
申请人： Gerhard Beck , Wilhelm Bartmann , Gunther Wess , Ernold Granzer
发明人： Gerhard Beck , Wilhelm Bartmann , Gunther Wess , Ernold Granzer
IPC分类号： A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C29/147 , C07C33/48 , C07C45/56 , C07C47/55 , C07C59/56 , C07C67/00 , C07C67/31 , C07C67/343 , C07C69/65 , C07C69/732 , C07C69/738 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/79 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
CPC分类号： C07D207/333 , C07C33/486 , C07C45/56 , C07C47/55 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
摘要： 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II ##STR1## in which R.sup.1 and R.sup.2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
摘要翻译： 式I的6-氟-3,5-二羟基羧酸衍生物和其中R1和R2具有特定含义的式II的相应内酯，其制备方法，其用途为 描述了药物和药物。 此外，描述了用于制备式I或式II化合物的新中间体。
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23.发明授权3-demethylmevalonic acid derivatives, and pharmaceutical products based on these compounds 失效3-脱甲基甲基戊酸衍生物和基于这些化合物的药物产品
公开(公告)号：US4925852A
公开(公告)日：1990-05-15
申请号：US216458
申请日：1988-07-08
申请人： Kurt Kesseler , Gerhard Beck , Wilhelm Bartmann , Ernold Granzer
发明人： Kurt Kesseler , Gerhard Beck , Wilhelm Bartmann , Ernold Granzer
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07F7/18
CPC分类号： C07D239/26 , C07D213/55 , C07D405/06 , C07F7/1856
摘要： 3-Demethylmevalonic acid derivatives of the formula I (.delta.-lactone) and II (corresponding dihydroxy carboxylic acid derivative) ##STR1## in which A--B, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments, and pharmaceutical products, are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.
摘要翻译： 其中AB，Z，R1，R2，R3和R4具有指定含义的式I（δ-内酯）和II（相应的二羟基羧酸衍生物）的3-甲基甲基戊酸衍生物，其制备方法 描述了这些化合物，它们作为药物的用途和药物产品。 此外，描述了用于制备式I和式II化合物的新中间体。
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公开(公告)号：US4745120A
公开(公告)日：1988-05-17
申请号：US767965
申请日：1985-08-21
申请人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
发明人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61P3/06 , A61P35/00 , A61P43/00 , C07D213/30 , C07D213/48 , C07D213/50 , C07D213/51 , C07D213/55 , C07D213/80 , C07D317/00 , C07D333/00 , C07D405/10 , C07D409/10 , C07D409/12 , C07F9/40 , C12N9/99 , A61K31/455 , C07D401/12
CPC分类号： C07D213/30 , C07D213/48 , C07D213/50 , C07D213/55 , C07D213/80 , C07D409/10 , C07D409/12 , C07F9/4006
摘要： The present invention relates to new pyridines substituted in the 3-position, of the formula ##STR1## and to a process for their preparation. The compounds bring about specific inhibition of thromboxane synthetase and can thus be used as medicaments.
摘要翻译： 本发明涉及在3-位上被取代的式（IMAGE）的新吡啶及其制备方法。 这些化合物对凝血恶烷合成酶具有特异性抑制作用，因此可用作药物。
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公开(公告)号：US4665080A
公开(公告)日：1987-05-12
申请号：US751550
申请日：1985-07-03
申请人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
发明人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hans-Hermann Lau
IPC分类号： C07D409/12 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P9/00 , C07D233/56 , C07D233/60 , C07D333/00 , C07D401/12 , C07D521/00 , C12N9/99 , C07D233/54
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The present invention relates to new ortho-, meta- and para-substituted imidazolylmethylstyrenes of the formula I ##STR1## and to a process for their preparation. The compounds according to the invention are distinguished by having a specific inhibitory effect on the synthesis of thromboxane, and hence they can be used as medicaments.
摘要翻译： 本发明涉及式I的新的邻位，间位和对位取代的咪唑基甲基苯乙烯及其制备方法。 根据本发明的化合物的特征在于对凝血恶烷的合成具有特异性抑制作用，因此它们可以用作药物。
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26.发明授权6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia 失效6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-硫代氧甲基-4-羟基四氢吡喃-2-酮及相应的二羟基羧酸衍生物，盐和酯，以及治疗高胆固醇血症
公开(公告)号：US5166171A
公开(公告)日：1992-11-24
申请号：US680613
申请日：1991-04-02
申请人： Heiner Jendralla , Gunther Wess , Wilhelm Bartmann , Gerhard Beck
发明人： Heiner Jendralla , Gunther Wess , Wilhelm Bartmann , Gerhard Beck
IPC分类号： C07C59/68 , C07C323/09 , C07D309/30
CPC分类号： C07C59/68 , C07C323/09 , C07D309/30 , Y10S514/824
摘要： 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.
摘要翻译： 6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-噻吩氧基甲基-4-羟基四氢吡喃-2-酮以及相应的二羟基羧酸衍生物，盐和酯，用于制备这些化合物的方法，它们作为药物，药物制剂和 新型酚类和噻吩类化合物通式Ⅰ的化合物及其相应的式Ⅱ的开环二羟基羧酸，其中X，Y和Z具有给定的含义，其药理学上可容许的盐与碱和 描述了其药理学耐受的酯，制备这些化合物的方法，它们作为药物和药物制剂的用途。 还描述了其中X，Y和Z具有给定的含义的式III“III”的新型酚类和噻吩类。
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27.发明授权3-pyridylmethylnaphthyl derivatives and composition containing them useful to inhibit thromboxane synthetase 失效3-吡啶基甲基萘基衍生物和含有它们的组合物可用于抑制凝血恶烷合成酶
公开(公告)号：US4734406A
公开(公告)日：1988-03-29
申请号：US838547
申请日：1986-03-11
申请人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
发明人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4418 , A61P7/02 , A61P43/00 , C07D213/26 , C07D213/30 , C07D213/42 , C07D213/50 , C07D213/53 , C07D213/55 , A61K31/535 , C07D413/10
CPC分类号： C07D213/30 , C07D213/26 , C07D213/42 , C07D213/55
摘要： Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds, are described. The compounds inhibit thromboxane synthetase and can thus be used as medicaments.
摘要翻译： 描述了其中R 1，R 2，R 3和Y具有指定含义的式I“I”化合物，其生理上耐受的酸加成盐，以及这些化合物的制备方法。 该化合物可抑制血栓素合成酶，因此可用作药物。
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公开(公告)号：US4778817A
公开(公告)日：1988-10-18
申请号：US838565
申请日：1986-03-11
申请人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
发明人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
IPC分类号： A61K31/415 , A61P7/02 , C07D233/56 , C07D233/64 , C07D521/00 , C07D233/60
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds are described. The compounds inhibit thromboxane synthetase and can thus be used as medicaments.
摘要翻译： 描述了其中R1，R2和Y具有指定含义的式I的化合物，其生理上耐受的酸加成盐，以及这些化合物的制备方法。 该化合物可抑制血栓素合成酶，因此可用作药物。
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29.发明授权4-substituted .DELTA.2-imidazolinyl-thioethers with prostaglandin-like activity 失效具有前列腺素样活性的4-取代的DELTA 2-咪唑啉基 - 硫醚
公开(公告)号：US4610999A
公开(公告)日：1986-09-09
申请号：US659772
申请日：1984-10-11
申请人： Gerhard Beck , Wilhelm Bartmann , Hans-Hermann Lau , Gunther Wess
发明人： Gerhard Beck , Wilhelm Bartmann , Hans-Hermann Lau , Gunther Wess
IPC分类号： A61K31/415 , A61K31/4166 , A61P1/04 , A61P1/12 , A61P9/08 , A61P9/12 , A61P43/00 , C07D233/32 , C07D233/38 , C07D233/42 , C07D233/70 , C07D409/06 , C07D409/12
CPC分类号： C07D409/06 , C07D233/32 , C07D233/38 , C07D233/42 , C07D233/70 , C07D409/12
摘要： The present invention relates to 4-substituted .DELTA.2-imidazolinyl-thioethers and to intermediates and processes for their preparation. The components according to the invention are distinguished in particular by their platelet aggregation-inhibiting and hypotensive action.
摘要翻译： 本发明涉及4-取代的DELTA 2-咪唑啉基 - 硫醚及其中间体及其制备方法。 根据本发明的组分特别地通过其血小板聚集抑制和降血压作用来区分。
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30.发明授权3-demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates 失效3-脱甲基-4-氟代戊二酸衍生物，其制备方法，基于这些化合物的药物产品，其用途和中间体
公开(公告)号：US4898868A
公开(公告)日：1990-02-06
申请号：US216752
申请日：1988-07-08
IPC分类号： C07D213/30 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61P3/06 , A61P9/10 , C07C45/68 , C07C47/55 , C07C51/00 , C07C51/09 , C07C59/00 , C07C59/125 , C07C59/68 , C07C59/72 , C07C59/90 , C07C67/00 , C07C313/00 , C07C323/52 , C07C333/04 , C07D309/10 , C07D309/30 , C07D405/06 , C07D405/10 , C07D407/12 , C07D409/06 , C07D409/12 , C07D493/04 , C07D493/14 , C07F7/18 , C07H15/18
CPC分类号： C07D405/06 , C07C323/00 , C07C45/68 , C07C47/55 , C07C59/68 , C07C59/72 , C07D309/10 , C07D309/30 , C07D409/06 , C07F7/1856
摘要： 3-Demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates3-Demethyl-4-fluoromevalonic acid derivatives of the formula I, and the corresponding dihydroxy carboxylic acid derivatives of the formula II ##STR1## in which R, X and Y have the stated meanings, processes for the preparation of these compounds, the use thereof as medicaments, and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.
摘要翻译： 3-脱甲基-4-氟代戊二酸衍生物，其制备方法，基于这些化合物的药物产品，其用途和中间体式I的3-去甲基-4-氟代甲基戊酸衍生物和相应的二羟基羧酸 其中R，X和Y具有所述含义的式II“IMAGE”衍生物，这些化合物的制备方法，其作为药物的用途以及药物产品。 此外，描述了用于制备式I和式II化合物的新中间体。
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