公开(公告)号：US20110112506A1

公开(公告)日：2011-05-12

申请号：US13009519

申请日：2011-01-19

申请人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

发明人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

IPC分类号： A61M5/168

CPC分类号： A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/30

摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

公开(公告)号：US20110082356A1

公开(公告)日：2011-04-07

申请号：US12572087

申请日：2009-10-01

申请人： Qingling Yang ,  Rajiv Shah ,  Megan E. Little ,  Chia-Hung Chiu

发明人： Qingling Yang ,  Rajiv Shah ,  Megan E. Little ,  Chia-Hung Chiu

IPC分类号： A61B5/1473 ,  G01N27/26 ,  C12Q1/26 ,  B05D3/00 ,  C08F120/26 ,  C08G73/00 ,  C08L33/10 ,  C09D133/10

CPC分类号： C12Q1/006 ,  Y02P20/582

摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施例提供了具有优化元件的电流分析传感器，例如干扰抑制膜以及制造和使用这种传感器的方法。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

公开(公告)号：US20100331647A1

公开(公告)日：2010-12-30

申请号：US12503753

申请日：2009-07-15

申请人： Rajiv Shah ,  Rebecca K. Gottlieb ,  Eric A. Grovender ,  Shaun M. Pendo ,  Paul Citron ,  William P. Van Antwerp

发明人： Rajiv Shah ,  Rebecca K. Gottlieb ,  Eric A. Grovender ,  Shaun M. Pendo ,  Paul Citron ,  William P. Van Antwerp

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/412 ,  G01N33/5438

摘要： A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.

摘要翻译： 一种用于测量使用者身体中的至少一种分析物的长期分析物传感器，其包括壳体，多个分析物接触传感器元件和用于将信息远离传感器中继的至少一个结构。 该多个分析物接触传感器元件通常以阵列方式设置。 分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使传感器元件被激活（例如暴露于外部环境）的方式被控制，以便延长传感器的使用寿命。 在说明性的分析物传感器中，分析物是葡萄糖。

公开(公告)号：US07774038B2

公开(公告)日：2010-08-10

申请号：US11323216

申请日：2005-12-30

申请人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

发明人： Lu Wang ,  Rajiv Shah ,  Wayne A. Morgan ,  Barry Keenan

IPC分类号： A61B5/05 ,  A61B5/00 ,  G01N33/50 ,  G01N33/487

CPC分类号： A61B5/1495 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B2560/0223 ,  A61M2005/1726

摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

摘要翻译： 用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。 使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计 电极（Vmeasured）随着时间的推移。 然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。 可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。 然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

公开(公告)号：US20100030045A1

公开(公告)日：2010-02-04

申请号：US12184117

申请日：2008-07-31

申请人： Rebecca K. Gottlieb ,  Rajiv Shah ,  Eric Allan Larson ,  Chia Chiu

发明人： Rebecca K. Gottlieb ,  Rajiv Shah ,  Eric Allan Larson ,  Chia Chiu

IPC分类号： A61B5/1473

CPC分类号： A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006

摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US07577470B2

公开(公告)日：2009-08-18

申请号：US10989038

申请日：2004-11-15

申请人： Rajiv Shah ,  Rebecca K. Gottlieb ,  Eric A. Grovender ,  Shaun Pendo ,  Paul Citron ,  William P. Van Antwerp

发明人： Rajiv Shah ,  Rebecca K. Gottlieb ,  Eric A. Grovender ,  Shaun Pendo ,  Paul Citron ,  William P. Van Antwerp

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/412 ,  G01N33/5438

摘要： A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.

摘要翻译： 一种用于测量使用者身体中的至少一种分析物的长期分析物传感器，其包括壳体，多个分析物接触传感器元件和用于将信息远离传感器中继的至少一个结构。 该多个分析物接触传感器元件通常以阵列方式设置。 分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使传感器元件被激活（例如暴露于外部环境）的方式被控制，以便延长传感器的使用寿命。 在说明性的分析物传感器中，分析物是葡萄糖。

公开(公告)号：US20090203979A1

公开(公告)日：2009-08-13

申请号：US12419188

申请日：2009-04-06

申请人： Wayne A. Morgan ,  David Choy ,  John C. Gord ,  Rajiv Shah

发明人： Wayne A. Morgan ,  David Choy ,  John C. Gord ,  Rajiv Shah

IPC分类号： A61B5/1468 ,  A61B5/04

CPC分类号： A61N1/05 ,  A61B5/042 ,  G01R27/14

摘要： An electronic circuit for sensing an output of a sensor having at least one electrode pair and circuitry for obtaining and processing the sensor output. The electrode pair may be laid out such that one electrode is wrapped around the other electrode in a U-shaped fashion. The electronic circuitry may include, among other things, a line interface for interfacing with input/output lines, a rectifier in parallel with the line interface, a counter connected to the line interface and a data converter connected to the counter and the electrode pair. The data converter may be a current-to-frequency converter. In addition, the rectifier may derive power for the electronic circuit from communication pulses received on the input/output lines.

摘要翻译： 一种用于感测具有至少一个电极对的传感器的输出和用于获得和处理传感器输出的电路的电子电路。 可以布置电极对，使得一个电极以U形方式缠绕在另一个电极周围。 电子电路可以包括用于与输入/输出线接口的线路接口，与线路接口并联的整流器，连接到线路接口的计数器和连接到计数器和电极对的数据转换器。 数据转换器可以是电流 - 频率转换器。 此外，整流器可以从输入/输出线上接收的通信脉冲导出电子电路的功率。

公开(公告)号：US20090177281A1

公开(公告)日：2009-07-09

申请号：US12405840

申请日：2009-03-17

申请人： Aaron J. Swanson ,  Jennifer M. Reynolds ,  Rajiv Shah

发明人： Aaron J. Swanson ,  Jennifer M. Reynolds ,  Rajiv Shah

IPC分类号： A61F2/02 ,  A61B19/02

CPC分类号： A61L2/18 ,  A61B5/1486 ,  A61B5/1495 ,  A61L2/08 ,  A61L2/206 ,  A61L2202/24 ,  Y10S422/905

摘要： A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.

摘要翻译： 浸在无菌缓冲液中的无菌装置及其提供方法。 无菌装置可以是诸如生物传感器的医疗装置，其具有生物分子作为感测元件，例如葡萄糖氧化酶。 缓冲液可以是碳酸氢盐溶液。 设备和缓冲液都可以长期包装和储存，同时保持灭菌。 灭菌方法可以包括气体，液体和光灭菌的组合。

公开(公告)号：US07514038B2

公开(公告)日：2009-04-07

申请号：US10861976

申请日：2004-06-04

申请人： Shaun Pendo ,  Rajiv Shah ,  Edward Chernoff

发明人： Shaun Pendo ,  Rajiv Shah ,  Edward Chernoff

IPC分类号： G01N21/00 ,  H05K3/40 ,  H05K1/03

CPC分类号： H05K3/28 ,  A61B5/0006 ,  H05K1/0306 ,  H05K3/4061 ,  H05K2201/0175 ,  H05K2201/0179 ,  H05K2201/0317 ,  H05K2201/09472 ,  H05K2203/082 ,  H05K2203/085 ,  H05K2203/1147 ,  H05K2203/1476 ,  H05K2203/1572 ,  H05K2203/308

摘要： A substrate with hermetically sealed vias extending from one side of the substrate to another and a method for fabricating same. The vias may be filled with a conductive material such as, for example, a fritless ink. The conductive path formed by the conductive material aids in sealing one side of the substrate from another. One side of the substrate may include a sensing element and another side of the substrate may include sensing electronics.

摘要翻译： 具有从衬底的一侧延伸到另一侧的气密密封通孔的衬底及其制造方法。 通孔可以填充有导电材料，例如无油墨。 由导电材料形成的导电路径有助于将基板的一侧与另一侧密封。 衬底的一侧可以包括感测元件，并且衬底的另一侧可以包括感测电子器件。

公开(公告)号：US07468033B2

公开(公告)日：2008-12-23

申请号：US10935954

申请日：2004-09-08

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

IPC分类号： A61B5/00 ,  A61M37/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。