公开(公告)号：US5366903A

公开(公告)日：1994-11-22

申请号：US199858

申请日：1994-02-22

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N33/49 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/80 ,  G01N21/84 ,  G01N33/48 ,  G01N33/497 ,  G01N33/84 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/03 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/05 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: A sampling device for photometric determination of the content of an analyte in a sample of whole blood has at least one measuring chamber having two wall parts, at least one wall part being locally transparent, at least one wall part being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber. The measuring chamber also contains a transparent body having a radiation transmission characteristic dependent upon the concentration of a predetermined analyte in the whole blood sample. The sample device is employed in an analyzer for photometric determination of the content of an analyte in a sample of whole blood and in a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. In the method, a sample of whole blood is transferred directly from an in vivo locality to the sampling device, the measuring chamber therein is deformed in a controlled manner to substantially drain the whole blood from the measuring chamber, radiation is transmitted through the substantially drained measuring chamber, detected, and the analyte content determined.

Abstract translation: 用于对全血样品中的分析物的含量进行光度测定的取样装置具有至少一个具有两个壁部分的测量室，至少一个壁部分局部透明，至少一个壁部分具有足够的可变形性， 来自测量室的全血样品。 测量室还包含具有取决于全血样品中预定分析物浓度的辐射透射特性的透明体。 样品装置用于用于光度测定全血样品中的分析物的含量的分析仪中，以及全血样品中分析物的含量的光度测定方法。 在该方法中，将全血样品直接从体内局部转移到采样装置，其中的测量室以受控的方式变形，从而从测量室基本上排出全部血液，辐射通过基本排出的 测量室，检测，并确定分析物含​​量。

公开(公告)号：US5309775A

公开(公告)日：1994-05-10

申请号：US778850

申请日：1992-01-29

Applicant: Joergen Andersen ,  Kristian J. Hvidtfeldt ,  Ib O. Sinnerup

Inventor： Joergen Andersen ,  Kristian J. Hvidtfeldt ,  Ib O. Sinnerup

IPC: G01N35/10 ,  G01N35/06

CPC classification number: G01N35/1002 ,  G01N2035/1006 ,  G01N35/1079

Abstract: New apparatus for measuring parameters such as pH, pCO.sub.2, pO.sub.2, and Hb content of physiological fluids, especially blood, is described. The apparatus comprises novel means for suspending reagent vessels (34, 35, 40, 45, 50) having shoulders (51, 52) and containing calibrating solutions, rinsing solutions etc., as well as for suspending a liquid waste vessel (26) by suspending the vessels between rods (53, 54) fed to the analyser. The reagent vessels are provided with caps (55, 58) at the top and include liquid reagent conduit extending from the outlet aperture of the cap down into the liquid. When the vessel is mounted on the analyser a fixed inlet tube extending horizontally outwardly from the analyser penetrates a seal across the outlet aperture and connects with the liquid reagent conduit.

Abstract translation: PCT No.PCT / DK90 / 00147 Sec。 371日期1992年1月29日 102（e）日期1992年1月29日PCT Filed 1990年6月13日PCT公布。 公开号WO91 / 00520 日期：1991年1月10日。描述了用于测量诸如生理液体，特别是血液中的pH，pCO 2，pO 2和H b含量的参数的新设备。 该装置包括用于悬挂具有肩部（51,52）并包含校准溶液，漂洗溶液等的试剂容器（34,35,40,45,50）的新颖装置，以及用于将液体废物容器（26）悬浮在 将容器悬挂在馈送到分析器的杆（53,54）之间。 试剂容器在顶部设置有帽（55,58），并且包括从帽的出口孔向下延伸到液体中的液体试剂导管。 当容器安装在分析器上时，从分析仪水平向外延伸的固定入口管穿过出口孔并穿过液体试剂导管连接。

公开(公告)号：US5242835A

公开(公告)日：1993-09-07

申请号：US917905

申请日：1992-07-21

Applicant: Niels-Henrik Jensen

Inventor： Niels-Henrik Jensen

IPC: G01N21/62 ,  G01N21/64 ,  G01N35/10

CPC classification number: G01N21/643 ,  G01N2021/6482 ,  G01N2035/1062 ,  G01N21/274 ,  Y10T436/207497

Abstract: The concentration of molecular oxygen in a sample is determined by exciting oxygen molecules of the sample from the electronic ground state to the excited .sup.1 .DELTA..sub.g state (excited singlet state), measuring a 1270-nm luminescence characteristic of the excited oxygen molecules (singlet oxygen) and correlating the luminescence characteristic measured with the concentration of molecular oxygen in the sample. Normally, the 1270-nm luminescence characteristic is the 1270-nm luminescence intensity. Preferably, the oxygen molecules are excited by being subjected to diffusion contact with a sensitizer such as a porphyrin or a porphyrin-related compound, e.g. a transition metal complex of a porphyrin. The sensitizer is brought into an oxygen-exciting electronic state by absorption of electromagnetic radiation such as light, the oxygen-exciting electronic state optionally being adapted to the measuring system employed by means of a quencher such as a substituted polyene. The sensitizer may be present in an organic solvent or a polymer such as polyvinylchloride. The oxygen-containing sample is preferably a sample of biological origin such as a blood sample.

Abstract translation: 样品中分子氧的浓度通过将样品从电子基态的氧分子激发到激发的1TTA状态（激发单态）来测定，测量激发的氧分子（单线态氧）的1270nm发光特性 ）并将测量的发光特性与样品中分子氧的浓度相关联。 通常，1270nm发光特性是1270nm发光强度。 优选地，氧分子通过与敏化剂例如卟啉或卟啉相关化合物例如与卟啉相互扩散接触来激发。 卟啉的过渡金属络合物。 通过吸收诸如光的电磁辐射将敏化剂引入氧激发电子状态，氧激发电子状态任选地适合于通过诸如取代多烯的猝灭剂使用的测量系统。 敏化剂可以存在于有机溶剂或聚合物如聚氯乙烯中。 含氧样品优选为生物来源的样品，例如血液样品。

公开(公告)号：US4997769A

公开(公告)日：1991-03-05

申请号：US512038

申请日：1990-04-13

Applicant: Finn C. Lundsgaard

Inventor： Finn C. Lundsgaard

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2021/3129 ,  Y10T436/113332

Abstract: Method and apparatus for spectrophotometrically determining the concentration of a number of hemoglobin derivatives comprising at least deoxyhemoglobin and oxyhemoglobin or parameters derived from the concentration of individual hemoglobin derivatives, in particular the oxygen saturation fraction, in whole blood, in which light is transmitted to the blood under test, the modification on the light transmitted to the blood which the blood causes is determined at a number of individual wavelengths, and the concentrations (or the derived parameters) are determined on the basis of the light modification at the individual wavelengths and on the basis of predetermined coefficients representing the light absorption characteristics of each of the hemoglobin derivatives at each of the individual wavelengths, any error on the determination values due to turbidity being substantially compensated for by utilizing predetermined coefficients representing an absorption characteristic of turbidity at each of the wavelengths. The measurement is normally performed at a number of wavelengths which is at least equal to the number of hemoglobin derivatives to be determined plus one. Although the turbidity-caused contribution to the total reduction in the light transmission is not based on any direct proportionality between the reduction in light transmission and the concentration of the turbidity-causing components (such as is the case with the hemoglobin derivatives), the "absorbances" caused by the turbidity at each particular wavelength may simply be eliminated from the equation set from which the concentrations of the hemoglobin derivatives are calculated.

Abstract translation: 用于分光光度测定多种血红蛋白衍生物的浓度的方法和装置，所述血红蛋白衍生物至少包含脱氧血红蛋白和氧合血红蛋白或衍生自单个血红蛋白衍生物浓度的参数，特别是全血中的氧饱和度，其中光透射到血液中 在测试中，在多个单个波长处确定传输到血液引起的血液的光的变化，并且基于各个波长处的光修饰确定浓度（或导出的参数），并且在 基于表示各个波长中的每一个的每个血红蛋白衍生物的光吸收特性的预定系数的基础，通过利用表示在e处的浊度的吸收特性的预定系数来基本上补偿由浊度导致的确定值上的任何误差 ach的波长。 测量通常以至少等于要确定的血红蛋白衍生物数目加上一个的多个波长进行。 虽然对透光性的总体减少的浊度引起的贡献不是基于光透射的降低与浊度成分的浓度（例如血红蛋白衍生物的情况）之间的任何直接比例关系，但是“ 可以简单地从计算出血红蛋白衍生物的浓度的方程组中消除由每个特定波长的浊度引起的吸光度。

公开(公告)号：US4687000A

公开(公告)日：1987-08-18

申请号：US713911

申请日：1985-03-15

Applicant: Anne R. Eisenhardt ,  Ole M. Hansen

Inventor： Anne R. Eisenhardt ,  Ole M. Hansen

IPC: A61B5/15 ,  G01N33/48 ,  A61B5/00

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150213 ,  G01N33/48 ,  A61B5/150236 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150587 ,  A61B5/150717

Abstract: In order to counteract coagulation of a blood sample which is collected from an animal or a human body (24) and introduced into a receptacle, such as a syringe chamber (14), an anticoagulant is added to the sample within the receptacle. The anticoagulant may be capable of binding cation species in the blood, which are subsequently to be measured. Such cation species comprise hydrogen ions, ammonium ions, alkaline metal ions such as potassium and sodium ions, and alkaline earth metal ions such as magnesium and calcium ions. In order to compensate for the proportions of selected cation species which are bound by the anticoagulant, an additive containing such cation species is added to the blood sample so as to obtain substantially the same concentration of the selected cation species in an unbound condition in the anticoagulant treated blood sample as in the untreated blood sample.The anticoagulant and the additive are preferably added to the blood sample as a composition which may be deposited on or carried by a carrier body (15) which may be arranged within the receptacle in which the blood sample is introduced. The bulk density of the nonwetted carrier body is preferably smaller than the specific weight of the blood sample so as to avoid trapping of air bubbles within the receptacle. In its wetted condition the bulk density of the carrier body is preferably also different from the specific weight of the blood sample so that the carrier body (15) may be used as an agitating member improving mixing of the anticoagulant composition with the blood sample. The carrier body (15) may, for example, be made of filtering paper.

Abstract translation: PCT No.PCT / DK84 / 00069 Sec。 371日期：1985年3月15日 102（e）1985年3月15日PCT提交1984年7月13日PCT公布。 出版物WO85 / 00662 1985年2月14日。为了抵抗从动物或人体（24）收集并引入诸如注射器室（14）的容器中的血液样品的凝结，将抗凝剂加入 样品在容器内。 抗凝剂可能能够结合血液中的阳离子物质，随后进行测量。 这种阳离子种类包括氢离子，铵离子，碱金属离子如钾和钠离子，以及碱土金属离子如镁和钙离子。 为了补偿由抗凝血剂结合的所选择的阳离子种类的比例，将含有这种阳离子种类的添加剂加入到血液样品中，以便在抗凝血剂中获得基本上相同浓度的未结合的选择的阳离子物质 处理的血液样品如未处理的血液样品。 抗凝血剂和添加剂优选作为可以沉积在载体（15）上或由载体体（15）承载的组合物加入到血液样品中，所述载体体可以布置在引入血液样品的容器内。 非湿润载体的体积密度优选小于血液样品的比重，以避免在容器内捕获气泡。 在其湿润状态下，载体体积的体积密度优选也不同于血液样品的比重，使得载体主体（15）可以用作改善抗凝血剂组合物与血液样品混合的搅拌构件。 载体主体（15）可以例如由滤纸制成。

公开(公告)号：US4576595A

公开(公告)日：1986-03-18

申请号：US685962

申请日：1984-12-24

Applicant: Flemming Aas ,  Borge Jeppesen

Inventor： Flemming Aas ,  Borge Jeppesen

IPC: A61B5/154 ,  B01L3/14 ,  G01N1/12 ,  G01N33/48 ,  G01N33/49 ,  A61B10/00 ,  A61J1/00

CPC classification number: B01L3/50825 ,  Y10S220/19

Abstract: A capillary tube containing a sample is anaerobicly sealed by means of closure caps each comprising an end wall and a skirt portion. Each open end of the capillary tube is sealed by inserting the open tube end into the cap skirt portion, and in order to avoid that a volume of air is forced into the capillary tube, the space defined between the open tube end and the cap end wall is vented to the atmosphere through one or more venting passages defined in the walls of the closure cap or between the inner surface of the cap skirt portion and the adjacent outer peripheral surface of the capillary tube. The open tube end is brought into sealing engagement with sealing means on the cap end wall, and frictional engagement established between the inner surface of the cap skirt portion and adjacent outer peripheral surface parts of the capillary tube secures that said sealing engagement is maintained.

Abstract translation: 含有样品的毛细管通过各自包括端壁和裙部的封闭盖进行厌氧密封。 通过将开口管端插入帽裙部分来密封毛细管的每个开口端，并且为了避免大量的空气被迫进入毛细管，限定在开口管端和帽端之间的空间 壁通过限定在封闭盖的壁中的一个或多个通气通道或帽裙部分的内表面和毛细管的相邻外周表面之间排放到大气中。 开口管端与帽端壁上的密封装置密封接合，并且在帽裙部分的内表面和毛细管的相邻外周表面部分之间建立的摩擦接合确保了保持所述密封接合。

公开(公告)号：US4363633A

公开(公告)日：1982-12-14

申请号：US162430

申请日：1980-06-24

Applicant: Torben F. Christiansen

Inventor： Torben F. Christiansen

IPC: G01N27/26 ,  G01N27/27 ,  G01N27/416 ,  G01N27/56 ,  C09K3/00 ,  G01N27/46 ,  G01N27/50 ,  G01N33/48

CPC classification number: G01N27/4165 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/109163

Abstract: A reference liquid for calibration or quality control of instruments which determine ionized calcium and pH. The reference liquid contains both a particular calcium ion activity and a pH-buffer and can therefore be used for calibration of both the calcium-sensitive electrode and the pH-electrode in the instruments. The pH-buffer is a nitrogen-containing organic sulphonic acid and the salt of this acid, the acid having a pK in the range of 6.6-7.6. The reference liquid has an ionic strength of 0.15-0.17, a buffer capacity .beta. in the range of 0.04-0.10 and is packed in glass ampoules.

Abstract translation: 用于校准或质量控制的参考液体，用于确定电离钙和pH。 参考液含有特定的钙离子活性和pH缓冲液，因此可用于仪器中钙敏感电极和pH电极的校准。 pH缓冲液是含氮有机磺酸和酸的盐，该酸的pK在6.6-7.6的范围内。 参比液体的离子强度为0.15-0.17，缓冲能力β在0.04-0.10范围内，并被包装在玻璃安瓿中。

公开(公告)号：US4058447A

公开(公告)日：1977-11-15

申请号：US656873

申请日：1976-02-10

Applicant: Torbe Falch Christiansen

Inventor： Torbe Falch Christiansen

IPC: G01N27/30 ,  G01N27/46

CPC classification number: G01N27/404

Abstract: An electrode for polarographic measurement of the partial pressure of oxygen in gases or solutions, comprising a cathode in contact with and outwardly shielded by a gas permeable membrane, a silver/silver bromide half cell serving as anode, and a bromide-containing aqueous electrolyte in contact with the anode and the cathode, the bromide ion concentration of the electrolyte being between 10.sup.-4 and 5 .times. 10.sup.-3 M, preferably 5 - 6 .times. 10.sup.-4 M.

Abstract translation: 用于极性测量气体或溶液中氧分压的电极，包括与透气膜接触并向外屏蔽的阴极，用作阳极的银/溴化银半电池和含溴化物的含水电解质 与阳极和阴极接触，电解质的溴离子浓度在10-4-5×10-3M之间，优选5-6×10-4M。

公开(公告)号：US4058365A

公开(公告)日：1977-11-15

申请号：US678625

申请日：1976-04-20

Applicant: Soren-Christian Krogh

Inventor： Soren-Christian Krogh

IPC: G01N31/16

CPC classification number: G01N31/162 ,  Y10T436/116664

Abstract: A process for automatic titration wherein the dosage of titrant is controlled by a digital computer, the titration being started with at least one dosage of a preselected size, each dosage of titrant thereafter and throughout the total course of the titration being precalculated and controlled on the basis of transducer signal change per added titrant volume unit at the preceding dosages in such a way that the titrant dosages are relatively smallest around the equivalence point.

Abstract translation: 一种自动滴定的方法，其中滴定剂的用量由数字计算机控制，滴定以至少一种预先选定的剂量开始，此后每次剂量的滴定剂和整个滴定的整个过程都被预先计算并控制在 在以前的剂量下，每个添加的滴定剂体积单位的换能器信号变化的基础，使得滴定剂剂量在等价点周围相对较小。

公开(公告)号：US4017374A

公开(公告)日：1977-04-12

申请号：US508623

申请日：1974-09-23

Applicant: Flemming Aas ,  Ole Dollerup Jensen

Inventor： Flemming Aas ,  Ole Dollerup Jensen

IPC: G01N27/30 ,  G01N27/46

CPC classification number: G01N27/30

Abstract: Electrochemical measuring electrodes often have a thin foil-shaped membrane, e.g. made of a plastic foil, which is arranged at one end of a cylindrical portion of the electrode and maintained in position by means of a resilient ring-shaped member, e.g. an O-ring, which presses the folded-over edge portion of the membrane against the outside of the cylindrical portion. It is now suggested to guide the ring-shaped holding member in such a way on the cylindrical portion that it protrudes beyond the membrane and thereof. The guiding may be provided by means of a circumferential groove in the cylindrical portion near the membrane end thereof.

Abstract translation: 电化学测量电极通常具有薄的箔状膜，例如。 其由塑料箔制成，其布置在电极的圆柱形部分的一端并且通过弹性环形构件保持在适当位置。 O形环，其将膜的折叠边缘部分压靠在圆柱形部分的外侧。 现在建议以这样的方式将环形保持构件引导到其突出超过其膜的圆柱形部分上。 引导件可以通过在其膜端部附近的圆筒形部分中的周向槽来提供。