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21.发明公开公开(公告)号：US20240228999A9
公开(公告)日：2024-07-11
申请号：US18057800
申请日：2022-11-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thomas Greiner-Stoeffele , Stefan Schoenert
IPC: C12N9/52 , C07K14/195 , C12N5/071
CPC classification number: C12N9/52 , C07K14/195 , C12N5/0602 , C12Y304/24 , C12Y304/24028 , C12N2509/00
Abstract: The present disclosure provides the sequence of a Paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. The disclosure also includes blends with other proteases. Further disclosed are nucleotide sequences encoding the neutral protease.
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公开(公告)号：US20240219404A1
公开(公告)日：2024-07-04
申请号：US18557954
申请日：2022-04-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Felix Gruenewald , Victor Johann Raul Jeger , Martin Klammer , Philipp Schuetz , Maria von Holtey , Stephen Weber , Heike Wegmeyer , Ursula-Henrike Wienhues-Thelen
CPC classification number: G01N33/6893 , G16H50/20 , G01N2333/91188 , G01N2800/26 , G01N2800/50
Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being IGFBP7, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: PCT, IL6, a cardiac Troponin, Albumin, CRP, Bilirubin, Ferritin, ESM-1, Aspartate aminotransferase, a BNP-type peptide, Alanine aminotransferase, Creatinine, and suPAR, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being IGFBP7 and a second biomarker selected from the group consisting of: PCT, IL6, a cardiac Troponin, Albumin, CRP, Bilirubin, Ferritin, ESM-1, Aspartate aminotransferase, a BNP-type peptide, Alanine aminotransferase, Creatinine, and suPAR, or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.
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公开(公告)号：US12026089B2
公开(公告)日：2024-07-02
申请号：US17178834
申请日：2021-02-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Albert Puig
CPC classification number: G06F11/3688 , G01N35/00 , G01N35/00871 , G16B50/00 , G16B99/00 , G16H10/40 , H04L67/12
Abstract: A laboratory system is disclosed. The laboratory system comprises a plurality of laboratories comprising one or more analytical instruments for performing a plurality of analytical tests (T1-n) and providing analytical test results (TR1-n) and a remote computer communicatively connected to the laboratories. Each of the laboratories is configured to define test result validation criteria (C1-n) for validating at least one of the analytical test results (TR1-n) associated with the respective analytical tests (T1-n) of one of the plurality of laboratories. The remote computer is configured to define a plurality of profiles (P1-n) of validation criteria, to assign the profiles (P1-n) of test result validation criteria (C1-n) to one or more of the laboratories (102), and to perform an automatic validation of groups (G1-n) of the analytical test results (TR1-n) according to the profiles (P1-n) of test result validation criteria (C1-n).
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公开(公告)号：US12013405B2
公开(公告)日：2024-06-18
申请号：US17510459
申请日：2021-10-26
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Sascha Antoni , Christian Vogl
IPC: G01N33/82 , C07C401/00
CPC classification number: G01N33/82 , C07C401/00 , Y10T436/203332
Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.
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公开(公告)号：US11994385B2
公开(公告)日：2024-05-28
申请号：US17318085
申请日：2021-05-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Richard-Paul Daisley
CPC classification number: G01B21/24 , G01N35/04 , G01N2035/0432
Abstract: An apparatus for measuring an angle between a longitudinal axis of a sample container inserted into an opening of a sample container carrier and a reference ray, the apparatus comprising a first accelerometer being fixable to the sample container and being adapted to generate a number of first accelerometer signals being dependent on the orientation of the sample container, and a calculation unit being coupled to the first accelerometer and being adapted to calculate the angle depending on the number of first accelerometer signals.
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Patent Agency Ranking
公开(公告)号：US20240140995A1
公开(公告)日：2024-05-02
申请号：US18542054
申请日：2023-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Romina Eisenhauer , Alfred Engel , Ute Jucknischke , Michael Schraeml , Wojtek Steffen
IPC: C07K14/195 , G01N33/543
CPC classification number: C07K14/195 , G01N33/54353 , C07K2319/00 , G01N2333/245
Abstract: The present invention relates to a method of determining an analyte in a sample, said method comprising (a) contacting said sample with (i) a binding compound binding to said analyte, said binding compound comprising a binding agent and a first partner of an affinity pair (first affinity partner); and (ii) a second partner of the affinity pair (second affinity partner) coupled to a solid surface, to an indicator, and/or to a second binding agent; and (b) determining said analyte based on complexes formed in step (a); wherein one of said first affinity partner and said second affinity partner is a polypeptide comprising the amino acid sequence of SEQ ID NO:1 or a sequence at least 50% identical thereto, and wherein the other of said first affinity partner and said second affinity partner is a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or a sequence at least 50% identical thereto. The present invention also relates to a polypeptide comprising an amino acid sequence as specified in SEQ ID NO:1 or a sequence at least 50% identical thereto, wherein the amino acid at the position corresponding to position 77 in SEQ ID NO:1 is not a histidine; and to a polypeptide comprising an amino acid sequence as specified in SEQ ID NO:2 or a sequence at least 50% identical thereto, wherein (i) the amino acid at the position corresponding to position 17 in SEQ ID NO:2 is not a cysteine, in an embodiment is alanine, serine, leucine, isoleucine, or glycine and/or (ii) said polypeptide further comprises at least one functional peptide; and to fusion polypeptides, polypeptide complexes, polynucleotides and kit related to the aforesaid.
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公开(公告)号：US11971424B2
公开(公告)日：2024-04-30
申请号：US17043354
申请日：2019-03-20
Inventor： Yuichi Hirabayashi , Dai Inagi , Satoshi Yokotsuka , Youichi Aruga , Mohamed Abouelsoud
IPC: G01N33/68 , A01N1/02 , B01L3/00 , C07C309/65 , C07C309/73 , G01N1/40 , G01N21/01 , G01N21/31 , G01N21/33 , G01N21/64 , G01N27/414 , G01N33/52 , G01N33/532 , G01N33/543 , G01N33/569 , G01N33/72 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC classification number: G01N35/025 , G01N35/00623 , G01N35/1002 , G01N35/1065 , G01N2035/00465 , G01N2035/00653 , G01N2035/00891 , G01N2035/0443 , G01N2035/0453
Abstract: An automatic analyzer is provided which is easier to investigate when some troubles such as data abnormality occur in a sample analysis result as compared with an automatic analyzer according to the related art. The automatic analyzer includes: analysis units that perform analysis and quality control analysis for ensuring quality of the analysis; a storage medium that stores quality control results of the quality control analysis performed by the analysis units; a monitor that displays the quality control results; and a control PC that controls an operation of the analysis units (8, 9, and 16), executes, when an arbitrary result is selected from the quality control results stored in the storage medium, based on the selected quality control result, statistical calculation of the selected result and a quality control result performed in the past, and causes the monitor to display a statistical calculation screen as a statistical calculation result.
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公开(公告)号：US11959895B2
公开(公告)日：2024-04-16
申请号：US16961344
申请日：2018-11-30
Inventor： Daisuke Akieda , Takayuki Sugime , Izumi Ogata , Makoto Nogami
CPC classification number: G01N30/6043 , G01N30/24 , G01N30/34 , G01N30/7233
Abstract: The analysis apparatus includes a standby section which is provided between a dispensing operation of an analysis item B′ prior to an analysis item C and the sample analysis channel introduction. The sample analysis channel introduction is arranged prior to a data collection section of an analysis item A. The operation is started earlier but after a sample dispensing operation section of the analysis item A. A sample dispensing operation section of the analysis item C can be started earlier and the analysis time of the analysis item C can be moved to immediately after a sample analysis operation section of the analysis item B′. The analysis item A in a second cycle can be started earlier by the early start time of the analysis item C in a first cycle. A total processing time Tc can be shorter than a total processing time Tb.
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公开(公告)号：US20240110932A1
公开(公告)日：2024-04-04
申请号：US18541624
申请日：2023-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Johannes Pflieger , Nicole Pirkl , Martin Rempt , Christoph Zuth
CPC classification number: G01N33/743 , G01N30/7233 , G01N33/6848 , H01J49/0009 , G01N2030/027 , G01N2333/575 , G01N2496/00
Abstract: The present invention relates to a method of determining an analyte in a sample by mass spectrometry (MS), the method comprising (a) admixing a pre-determined amount of internal calibrator to said sample, wherein said internal calibrator comprises at least two non-identical isotopologues of the analyte at predetermined amounts; (b) determining MS signals of ions generated from said analyte (analyte signal) and from said at least two isotopologues (isotopologue signals); (c) providing a calibration based on the analyte signal and the isotopologue signals determined in step (b); and (d) determining said analyte based on the calibration provided in step (c). Further, the present invention relates to devices, systems, and uses related thereto.
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公开(公告)号：USD1014273S1
公开(公告)日：2024-02-13
申请号：US29816594
申请日：2021-11-23
Applicant: Roche Diagnostics Operations, Inc.
Designer： Alex Weymann
Abstract: The sole FIGURE is a perspective view of a bottle showing my new design.
The evenly broken lines are shown for the purpose of illustrating parts of the article that form no part of the claim. The dot-dash lines represent the boundaries of the claim and form no part thereof.
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