公开(公告)号：US20230414876A1

公开(公告)日：2023-12-28

申请号：US18244868

申请日：2023-09-11

Applicant: INTEGRIMEDICAL LLC

Inventor： Hassan Salari ,  Ankur Naik ,  Sambath Kumar Rajagopal

IPC: A61M5/20 ,  A61M5/315

CPC classification number: A61M5/2033 ,  A61M5/31511 ,  A61M5/31513

Abstract: A spring-loadable fluid injection device for a needle-free syringe is provided and comprises a trigger positioned within the housing and actuated by depression of a push button or lever disposed opposite the dispensing end at an external actuation surface. The trigger has a trigger latch configured to release a trigger catch as heaving part of the spring-loaded piston of the device. The trigger catch is configured to urge the trigger latch in a direction transverse to the injection axis when the piston moves from the unloaded position to the loaded position. The compression spring is retained around the piston and retained within the housing by a piston head. The device further comprises a syringe adapter and a safety cap which prevents accidental triggering. An embodiment further includes a prefilled syringe adapter for aseptic filling of a needle-free syringe from a prefilled syringe.

公开(公告)号：US11826550B2

公开(公告)日：2023-11-28

申请号：US17673166

申请日：2022-02-16

Applicant: TRUE CONCEPTS MEDICAL TECHNOLOGIES, LLC

Inventor： Michael Hopkins

IPC: A61M5/19 ,  A61M5/28 ,  A61M5/315 ,  A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61M5/32 ,  A61M5/178 ,  A61M5/31

CPC classification number: A61M5/19 ,  A61B5/153 ,  A61B5/15003 ,  A61B5/154 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150992 ,  A61M5/284 ,  A61M5/3158 ,  A61M5/31513 ,  A61M5/31596 ,  A61M5/32 ,  A61M2005/1787 ,  A61M2005/3128 ,  A61M2202/04

Abstract: A syringe-based device includes a housing and an actuator mechanism including a first member and a second member. The first member includes a syringe body and a plunger, the plunger being movably disposed within the syringe body. The second member includes a second member plunger seal and a valve operably and selectively coupled to the second member plunger seal such that the valve is positioned proximal of the second member plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which the first type of fluid is expelled from the first fluid reservoir, to a third configuration in which the second type of fluid is expelled from the second fluid reservoir through the valve.

公开(公告)号：US20230310681A1

公开(公告)日：2023-10-05

申请号：US18330083

申请日：2023-06-06

Applicant: F. HOFFMANN-LA ROCHE AG ,  GENENTECH, INC.

Inventor： Markus HEMMINGER ,  Ulla GRAUSCHOPF ,  Frank BAMBERG ,  Mayumi BOWEN ,  Robert MÜLLER ,  Flora FELSOVALYI ,  Denny CHRISTENSEN

IPC: A61L2/20 ,  A61M5/00 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  B65B3/00 ,  B65B7/28 ,  B65B55/10

CPC classification number: A61L2/206 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/3202 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/10 ,  A61L2202/23 ,  A61M2005/3114 ,  A61M2205/0238 ,  A61M2207/10 ,  A61M2207/00 ,  A61L2202/24 ,  A61M5/31513 ,  A61M2005/3104 ,  B65B55/02

Abstract: A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111), and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle adaptor cap (12) has a rubber element (121) tightly sealing the orifice (113) of the tip (112) of the syringe barrel (11) and the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) is sterilized by a first sterilizing comprising a main step of exposing the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 5 hours to about 60 hours at a relative humidity of about 40% to about 100% and at a temperature of about 30° C. to about 60° C.; (ii) filling a drug substance (14) through the open end (111) of the syringe barrel (11) into an interior of the syringe barrel; (iii) sealing the interior of the syringe barrel (11) by advancing a rubber stopper (13) through the open end (111) of the syringe barrel (11); (iv) packaging the syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11); and (v) second external surface sterilizing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11). The rubber element (121) of the needle adaptor cap (12) and the rubber stopper (13) are made of a rubber material having a comparably low oxygen transmission rate such as, at 1 atmosphere, of not more than 64 cubic centimeter per square meter and day. The second external surface sterilizing comprises a main step of exposing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 3 hours to about 30 hours at a relative humidity of about 40% to about 100% and at a temperature of about 25° C. to about 45° C. At least one of the duration, the relative humidity and the temperature of the second external surface sterilizing is essentially lower than the respective duration, relative humidity or temperature of the first sterilization.

公开(公告)号：US11771833B2

公开(公告)日：2023-10-03

申请号：US16007367

申请日：2018-06-13

Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.

Inventor： Hiroyuki Kaneko ,  Hiroaki Nakano

IPC: B23K26/02 ,  B29C35/08 ,  B29C65/16 ,  B29C69/00 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/31513 ,  B23K26/02 ,  B29C35/0805 ,  B29C65/16 ,  B29C69/00 ,  A61M2005/3101 ,  A61M2207/00

Abstract: Laminated gasket free from liquid drug leakage. Gasket (13) to be used for a medical syringe includes main body (14) made of an elastic material and film (15) on a surface of main body (14). Gasket (13) has a circumferential surface portion (17) that can contact an inner peripheral surface of syringe barrel (11) of the syringe, and has an annular groove (22) formed circumferentially in a surface portion of the film present in the circumferential surface portion thereof. Annular groove (22) has outer edge portions (24) provided along opposite edges (23) thereof as projecting from an unprocessed surface portion of the film. Annular groove (22) has groove formation start points and end points that are connected to each other in a groove connection region. Outer edge portions (24) along the opposite edges of the annular groove have a maximum-to-minimum height difference of ≤5 μm in the groove connection region.

公开(公告)号：US11744948B2

公开(公告)日：2023-09-05

申请号：US17097706

申请日：2020-11-13

Applicant: BAYER HEALTHCARE LLC

Inventor： Kevin Cowan ,  Damian Peter Francis Savio ,  Eric Siu ,  Richard Sokolov ,  Peter John Sprada

IPC: A61M5/19 ,  A61M5/00 ,  A61M5/145 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  A61M5/50 ,  A61M5/24 ,  A61M5/38 ,  A61M5/178

CPC classification number: A61M5/19 ,  A61M5/002 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/3146 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/5086 ,  A61M5/2466 ,  A61M5/38 ,  A61M2005/1787 ,  A61M2005/3101 ,  A61M2005/31518 ,  A61M2005/31598 ,  A61M2205/0222 ,  A61M2207/00 ,  A61M2209/06

Abstract: Provided is an apparatus, system, and method for a nested syringe assembly. The nested syringe assembly includes a first syringe having a cylindrical body defining an inner diameter and a second syringe having a cylindrical body defining an outer diameter. The outer diameter of the second syringe is less than the inner diameter of the first syringe. At least a portion of the cylindrical body of the second syringe is disposed within the cylindrical body of the first syringe.

公开(公告)号：US11730887B2

公开(公告)日：2023-08-22

申请号：US16756158

申请日：2018-10-23

Applicant: SANOFI

Inventor： Catherine Ebner

IPC: A61M5/20 ,  A61M5/315 ,  A61M5/32

CPC classification number: A61M5/2033 ,  A61M5/31513 ,  A61M5/3202 ,  A61M2205/0294 ,  A61M2205/8206

Abstract: An injection device is presented. The injection device comprises a housing configured to receive a syringe which has a barrel and a plunger received in the barrel. The injection device further comprises a vibration generator operable to vibrate at least one of the barrel and plunger when said syringe is received in the housing. Methods of dispensing medicament from an injection device are also presented.

公开(公告)号：US11724042B2

公开(公告)日：2023-08-15

申请号：US17121414

申请日：2020-12-14

Applicant: CREDENCE MEDSYSTEMS, INC.

Inventor： Gary Steese-Bradley ,  Stephen H. Diaz ,  Alan E. Shluzas ,  John F. Shanley ,  Jeff Tillack ,  Dan Thayer ,  John Merhige

IPC: A61M5/32 ,  A61M5/178 ,  A61M5/24 ,  A61M5/20 ,  A61M5/28 ,  A61M5/315 ,  A61M5/31 ,  A61J1/20

CPC classification number: A61M5/3221 ,  A61M5/178 ,  A61M5/2066 ,  A61M5/2448 ,  A61M5/28 ,  A61M5/284 ,  A61M5/3137 ,  A61M5/3148 ,  A61M5/31501 ,  A61M5/31511 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/322 ,  A61M5/3234 ,  A61J1/2006 ,  A61J1/2096 ,  A61M5/3232 ,  A61M5/3293 ,  A61M2005/323 ,  A61M2005/3223 ,  A61M2005/3231 ,  A61M2005/3241

Abstract: A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

公开(公告)号：US11717614B2

公开(公告)日：2023-08-08

申请号：US16812912

申请日：2020-03-09

Applicant: BAYER HEALTHCARE LLC

Inventor： Dave Berry ,  Kevin P. Cowan ,  Martin J. Gibler ,  Michael A. Spohn

IPC: A61M5/315 ,  A61M5/24 ,  A61M5/145

CPC classification number: A61M5/31513 ,  A61M5/145 ,  A61M5/14586 ,  A61M5/2425 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/14593 ,  A61M5/31515 ,  A61M2005/14513 ,  A61M2005/14553 ,  A61M2205/36

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. The distal end of the rolling diaphragm has a nozzle and a sidewall extending between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

公开(公告)号：US11707569B2

公开(公告)日：2023-07-25

申请号：US17032140

申请日：2020-09-25

Applicant: ClearPoint Neuro, Inc.

Inventor： Maxwell Jerad Daly ,  Peter G. Piferi

IPC: A61M5/145 ,  A61K35/28 ,  A61M5/315 ,  A61M25/01 ,  A61M39/10 ,  A61M5/14

CPC classification number: A61M5/1452 ,  A61K35/28 ,  A61M5/31513 ,  A61M5/31528 ,  A61M25/0102 ,  A61M39/10 ,  A61M2005/1403 ,  A61M2025/0166 ,  A61M2202/09 ,  A61M2205/0266 ,  A61M2210/0693

Abstract: Devices for transferring fluid to or from a subject include a plunger assembly coupled to or coupleable to a cannula assembly to allow target fluid to be “front-loaded” into a distal end of the cannula assembly while the stylet is withdrawn a distance to create a vacuum and define a flow channel.

公开(公告)号：US11684720B2

公开(公告)日：2023-06-27

申请号：US17822074

申请日：2022-08-24

Applicant: Excelsior Medical Corporation

Inventor： William Anderson ,  Mark Wilson ,  Gary Henniger ,  Larry Colquitt ,  Christopher E. Gardner ,  Chirag S. Walawalkar

IPC: A61M5/315 ,  A61M5/31 ,  A61M25/04 ,  A61M39/02 ,  A61M39/16 ,  A61M39/20 ,  A61M5/00 ,  A61M5/34 ,  A61M25/00 ,  A61M39/10

CPC classification number: A61M5/31511 ,  A61M5/31 ,  A61M25/04 ,  A61M39/02 ,  A61M39/16 ,  A61M39/162 ,  A61M39/20 ,  A61M5/001 ,  A61M5/002 ,  A61M5/3135 ,  A61M5/3137 ,  A61M5/31513 ,  A61M5/347 ,  A61M2005/3104 ,  A61M2005/31506 ,  A61M2025/0019 ,  A61M2039/1033

Abstract: An antiseptic medical cap that may include a base, a sidewall, and a chamber configured to receive a proximal end of a medical fluid port having an opening. The antiseptic medical cap, in some instances, may include an insert having a gas-releasing anti-microbial compound and/or include a nitric oxide-releasing system that is configured to be positioned at least partially through the opening of the medical fluid port when the antiseptic medical cap receives the proximal end of the medical fluid port into the chamber.