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公开(公告)号：US20180008147A1
公开(公告)日：2018-01-11
申请号：US15634456
申请日：2017-06-27
Applicant: Duke University
Inventor： Adam Wax , John W. Pyhtila
CPC classification number: A61B5/0084 , A61B1/00165 , A61B1/00172 , A61B5/0066 , A61B5/0075 , G01B9/02043 , G01B9/02044 , G01B9/02084 , G01B9/02087 , G01B9/0209 , G01B9/02091 , G01J3/45 , G01N21/31 , G01N21/4795 , G01N2021/4704 , G01N2021/4709 , G01N2021/4735 , G01N2201/08
Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.
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公开(公告)号：US20170363473A1
公开(公告)日：2017-12-21
申请号：US15540441
申请日：2016-02-03
Applicant: VITO NV
Inventor： Stefan LIVENS
CPC classification number: G01J3/45 , G01J3/26 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01J2003/2826 , G01J2003/2879
Abstract: A method for estimating an input spectrum from sensor data acquired by an optical sensor assembly, having an aperture, a Fabry-Perot interferometer, and an optical sensor element, the method including: obtaining first calibration data representative of a spectral response function of the optical sensor assembly for a first setting of the aperture; computing second calibration data from the first calibration data, the second calibration data being representative of a spectral response function of the optical sensor assembly for a second setting of the aperture, where the second setting corresponds to a setting applied during the acquiring of the sensor data; and estimating the input spectrum as a function of the second calibration data and the sensor data. Additionally, a corresponding system for estimating an input spectrum
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公开(公告)号：US20170314992A1
公开(公告)日：2017-11-02
申请号：US15363186
申请日：2016-11-29
Inventor： Michael Derek HARGREAVES , Timothy M. PASTORE , Gregory H. VANDER RHODES , Brendon D. TOWER
CPC classification number: G01J3/4412 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0291 , G01J3/28 , G01J3/44 , G01J3/45 , G01J3/453 , G01J2003/2833 , G01N21/35 , G01N21/65 , G01N2021/3595 , G01N2201/0221
Abstract: A spectrometer system comprising a housing configured as a handheld device with a screen; a source of narrow band illumination; a sensor that detects Raman scattering signals; a source of wide band illumination; an optical element that detect Fourier transform infrared (FTIR) signals; a memory device comprising a library of information with Raman scattering reference information and FTIR reference information; and a processor configured to execute software instructions, wherein the software instructions are configured to: direct the narrow band illumination to the sample; detect the Raman scattering signals; direct the wide band illumination to the sample; detect the FTIR signals; determine a composition of the sample from a similarity between the Raman scattering spectral information and the Raman scattering reference information, and from a similarity between the FTIR spectral information and the FTIR reference information; and display the composition of the sample on the screen.
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24.发明申请公开(公告)号：US20170280992A1
公开(公告)日：2017-10-05
申请号：US15627077
申请日：2017-06-19
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
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公开(公告)号：US09778113B2
公开(公告)日：2017-10-03
申请号：US14253250
申请日：2014-04-15
Inventor： Dirk R. Englund , Chaitanya Rastogi
CPC classification number: G01J3/45 , G01J3/0259 , G01J3/26 , G01J3/2823 , G01J3/32 , G01J2003/2826 , G01J2003/452
Abstract: Techniques for hyperspectral imaging, including a device for hyperspectral imaging including at least one tunable interferometer including a thin layer of material disposed between two or more broadband mirrors. Electrodes placed on either side of the tunable interferometer can be coupled to a voltage control circuit, and upon application of a voltage across the tunable interferometer, the distance between the mirrors can be modulated by physically altering the dimensions of the thin layer of material, which can uniformly load the broadband mirrors. Physically altering the dimensions of the thin layer of material can include one or more of deformation of a soft material, piezostrictrive actuation of a piezostrictrive material, or electrostrictive actuation of an electrostrictive material.
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Patent Agency Ranking
公开(公告)号：US09687157B2
公开(公告)日：2017-06-27
申请号：US14494080
申请日：2014-09-23
Applicant: Duke University
Inventor： Adam Wax , John W. Pyhtila
CPC classification number: A61B5/0084 , A61B1/00165 , A61B1/00172 , A61B5/0066 , A61B5/0075 , G01B9/02043 , G01B9/02044 , G01B9/02084 , G01B9/02087 , G01B9/0209 , G01B9/02091 , G01J3/45 , G01N21/31 , G01N21/4795 , G01N2021/4704 , G01N2021/4709 , G01N2021/4735 , G01N2201/08
Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.
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27.发明授权公开(公告)号：US09681802B2
公开(公告)日：2017-06-20
申请号：US14831678
申请日：2015-08-20
Applicant: ABBOTT MEDICAL OPTICS INC.
Inventor： Stanley W. Huth , Denise Tran
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/1005 , G01B11/06 , G01J3/45
Abstract: A method for determining reflectivity of a tear film lipid layer of a patient and recommending a course of treatment based on the same. The method includes the steps of: measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness; and determining a reflectivity value for the tear film lipid layer thickness at a first wavelength of light corresponding to ultraviolet, violet, or blue light.
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公开(公告)号：US09681798B2
公开(公告)日：2017-06-20
申请号：US14933666
申请日：2015-11-05
Applicant: Ian W. Hunter , Yi Chen
Inventor： Ian W. Hunter , Yi Chen
CPC classification number: A61B1/0638 , G01J3/0286 , G01J3/0291 , G01J3/1256 , G01J3/2823 , G01J3/45 , G01J3/453 , G01J3/4535
Abstract: Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators' transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.
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公开(公告)号：US09677949B1
公开(公告)日：2017-06-13
申请号：US14526168
申请日：2014-10-28
Inventor： Ming Han
CPC classification number: G01K11/3206 , G01J3/45 , G01J5/0821 , G01J5/602 , G01J2005/583 , G01K1/26 , G01K11/125
Abstract: An in-line fiber-optic temperature sensor is disclosed. In an implementation, the in-line fiber-optic temperature sensor includes an optically transmissive fiber, a reflector, a microstructured fiber defining a channel therein for receiving a fluid, and a Fabry-Perot cavity in fluid communication with the microstructured fiber. The microstructured fiber can be retained between the optically transmissive fiber and the reflector. The Fabry-Perot cavity defined by a material and configured to receive a gas having an index of refraction that changes in a known way with temperature and pressure changes in fluid communication with the channel of the microstructured fiber. The in-line fiber-optic temperature sensor also includes a chamber defined between the optically transmissive fiber and the microstructured fiber for connecting in fluid communication with a vacuum/pressure source for changing pressure. The in-line fiber-optic temperature sensor also includes a sensor for determining an optical interferometric reflection spectrum associated with the Fabry-Perot cavity.
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公开(公告)号：US20170146401A1
公开(公告)日：2017-05-25
申请号：US15321757
申请日：2015-06-17
Applicant: Spectral Engines Oy
Inventor： Jarkko Antila
CPC classification number: G01J3/26 , G01J3/0227 , G01J3/0286 , G01J3/28 , G01J3/45 , G01J9/0246 , G01J2003/2879 , G02B5/20 , G02F1/21
Abstract: A method for determining spectral calibration data (λcal(Sd), Sd,cal(λ)) of a Fabry-Perot interferometer (100) comprises: forming a spectral notch (NC2) by filtering input light (LB1) with a notch filter (60) such that the spectral notch (NC2) corresponds to a transmittance notch (NC1) of the notch filter (60), measuring a spectral intensity distribution (M(Sd)) of the spectral notch (NC2) by varying the mirror gap (dFP) of the Fabry-Perot interferometer (100), and by providing a control signal (Sd) indicative of the mirror gap (dFP), and determining the spectral calibration data (λcal(Sd), Sd,cal(λ)) by matching the measured spectral intensity distribution (M(Sd)) with the spectral transmittance (TN(λ)) of the notch filter (60).
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