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    Modified electrode buffers for stain-free protein detection in electrophoresis
    21.
    发明授权
    Modified electrode buffers for stain-free protein detection in electrophoresis 有权

    公开(公告)号：US09791408B2

    公开(公告)日：2017-10-17

    申请号：US14641633

    申请日：2015-03-09

    申请人： Bio-Rad Laboratories, Inc.

    发明人： Christopher Belisle

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44747 ,  G01N27/44713 ,  G01N27/44721 ,  G01N27/44726 ,  G01N27/44739

    摘要： Proteins that are electrophoretically separated in a gel are derivatized to produce fluorescent emissions by incorporating halo-substituted organic compounds into one or both of the electrode buffer solutions at the two ends of the gel. The halo-substituted compounds used are ones that bear an electric charge at the pH of the buffer solutions and gel, and the polarity of the charge on the compounds is such that the compounds migrate from the electrode buffer into the gel under the electrophoretic influence concurrently with the migration of the proteins into the gel. Once the proteins are separated and distributed within the gel and the gel is fully penetrated with the halo-substituted compounds, the gel is irradiated with ultraviolet light to induce a reaction between the halo-substituted compounds and the proteins through the tryptophan residues on the proteins, producing fluorescent reaction products.

    Sequencing System with Memory
    25.
    发明申请
    Sequencing System with Memory 审中-公开

    公开(公告)号：US20170153203A1

    公开(公告)日：2017-06-01

    申请号：US15346603

    申请日：2016-11-08

    申请人： APPLIED BIOSYSTEMS, LLC

    发明人： Jeffery D. Frazier

    IPC分类号： G01N27/447 ,  C12Q1/68

    CPC分类号： G01N27/44721 ,  C12Q1/6869 ,  G01N27/44782

    摘要： The present teachings provide a device including a memory. According to various embodiments, the memory is readable, writable, and rewritable. The present teachings further provide processing stations, e.g., for carrying out electrophoresis, per, genetic analysis, sample preparation, and/or sample cleanup, etc., that are capable of reading from and/or writing/rewriting to such memory.

    OPTICAL SYSTEM FOR CAPILLARY ELECTROPHORESIS
    30.
    发明申请
    OPTICAL SYSTEM FOR CAPILLARY ELECTROPHORESIS 审中-公开
    用于毛细管电泳的光学系统

    公开(公告)号：US20170016853A1

    公开(公告)日：2017-01-19

    申请号：US15124013

    申请日：2015-03-06

    申请人： Life Technologies Corporation

    发明人： Kevin MAHER

    IPC分类号： G01N27/447 ,  G01N21/64

    CPC分类号： G01N27/44721 ,  G01N21/645 ,  G01N27/44791 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/062

    摘要： A system for conducting a capillary electrophoresis assay includes a light source, an interface, and an illumination optical system. The light source is configured to provide a source beam of electromagnetic radiation. The interface is configured to receive a plurality of capillaries containing one or more target molecules or sequence of molecules. The illumination system is configured in use to produce a plurality of output beams from the source beam and to direct each of the output beams to corresponding capillary of the plurality of capillaries.

    摘要翻译： 用于进行毛细管电泳测定的系统包括光源，界面和照明光学系统。 光源被配置为提供电磁辐射的源束。 接口被配置为接收包含一个或多个靶分子或分子序列的多个毛细管。 照明系统被配置为用于从源光束产生多个输出光束并且将每个输出光束引导到多个毛细管中的相应毛细管。