摘要:
A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
摘要:
A nitrogen group containing silane of the formula ##STR1## where R is a C.sub.1 -C.sub.4 alkyl group which can contain an oxygen or sulfur atom in the chain, R' is a C.sub.1-4 alkyl radical or hydrogen, A is a bivalent, saturated, branched or unbranched hydrocarbon radical having 2 to 4 carbon atoms in the chain and B is a bivalent, saturated, branched or unbranched hydrocarbon radical having 1 to 10 carbon atoms in the chain; the use of such compounds in an adhesive composition containing an organic polyaddition or polycondensation polymer as an adhesivizing agent.
摘要:
The disclosure relates to derivatives of tetrahydro-1H-1,3-diazepine and hexahydro-1,3-diazocine of the general formula ##STR1## or pharmaceutically acceptable acid addition salts thereof wherein n represents 2 or 3, R.sup.3 and R.sup.4 which may be the same or different each represent hydrogen or lower alkyl, Ph represents phenyl, halophenyl, lower alkyl phenyl, di(lower alkyl) phenyl or lower alkoxy phenyl, R is hydroxyl, lower alkoxy or halogen, R.sup.1 is phenyl, halophenyl, lower alkyl phenyl, di(lower-alkyl phenyl, lower alkoxyphenyl or naphthyl and R.sup.6 is hydrogen or lower alkyl. The compounds have hypoglycemic activity.
摘要:
Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.
摘要:
Imidazolyl and tetrahydropyrimidyl benzofurans of the formula:
ARE DISCLOSED. In the above structure A, B, and C are hydrogen or lower alkyl of 1 to 6 carbon atoms, halogen, lower alkoxy of 1 to 6 carbon atoms, or an aromatic ring; R is hydrogen, lower alkyl of 1 to 6 carbon atoms, hydroxy, amino or an aromatic ring; D is hydrogen or lower alkyl of 1 to 6 carbon atoms, E is hydrogen, lower alkyl of 1 to 6 carbon atoms, or hydroxy; F is hydrogen, lower alkyl of 1 to 6 carbon atoms, or Beta hydroxyethyl and n is 0 or 1. These compounds are useful in the management of gastric hyperacidity and gastric ulcers.
摘要:
The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.
摘要:
The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
摘要:
A process for reacting, in the presence of a particular calcium containing catalyst, an amine having an active hydrogen and one or more of a fatty acid ester or a fatty acid.