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    ENZYMES AND APPLICATIONS THEREOF
    22.
    发明申请
    ENZYMES AND APPLICATIONS THEREOF 审中-公开

    公开(公告)号：US20200040369A1

    公开(公告)日：2020-02-06

    申请号：US16598317

    申请日：2019-10-10

    申请人： Givaudan SA

    发明人： Eric EICHHORN ,  Boris SCHILLING ,  Denis WAHLER ,  Laurent FOURAGE ,  Esther LOCHER

    IPC分类号： C12P17/04 ,  C12N9/90 ,  C07D307/92

    摘要： There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (−)-Ambrox and SHC/HAC enzymes in methods to prepare (−)-Ambrox.

    Recombinant Engineered Bacterium Co-Expressing Trans-Anethole Oxygenase and Formate Dehydrogenase and Application thereof in Production of Piperonal
    23.
    发明申请
    Recombinant Engineered Bacterium Co-Expressing Trans-Anethole Oxygenase and Formate Dehydrogenase and Application thereof in Production of Piperonal 审中-公开

    公开(公告)号：US20200010864A1

    公开(公告)日：2020-01-09

    申请号：US16517792

    申请日：2019-07-22

    申请人： Jiangnan University

    发明人： Pu Zheng ,  Dan Wu ,  Peng Wen ,  Pengcheng Chen ,  Yin Fu

    IPC分类号： C12P17/04 ,  C12N9/02 ,  C12N9/04

    摘要： The present application discloses a method for producing piperonal by using a recombinant engineered bacterium co-expressing trans-anethole oxygenase and formate dehydrogenase, and an engineered bacterium thereof, including constructing a formate dehydrogenase gene fdh and trans-anethole oxygenase gene tao or trans-anethole oxygenase mutant gene co-expression recombinant vector; inductively expressing recombinant genetically engineered bacterium; and producing piperonal by using the recombinant genetically engineered bacterium. 15.91 g/L of piperonal with a transformation rate of 79.55% and a time-space transformation rate of 2.27 g/L/h can be finally obtained during catalysis, and the yield is significantly improved compared with the existing piperonal, thereby being more conducive to the smooth realization of industrial production.

    YEAST AND USE THEREOF IN CATALYTICAL SYNTHESIS OF 2,5-DIHYDROXYMETHYLFURAN
    26.
    发明申请
    YEAST AND USE THEREOF IN CATALYTICAL SYNTHESIS OF 2,5-DIHYDROXYMETHYLFURAN 审中-公开

    公开(公告)号：US20190040430A1

    公开(公告)日：2019-02-07

    申请号：US16083510

    申请日：2016-12-15

    申请人： SOUTH CHINA UNIVERSITY OF TECHNOLOGY

    发明人： Ning LI ,  Yanmei LI ,  Minhua ZONG

    IPC分类号： C12P17/04

    摘要： A yeast strain and a method for the synthesis of 2,5-dihydroxymethylfuran using this strain are disclosed. The yeast strain is Meyerozyma guilliermondii SC 1103, which has been maintained in the China Center for Type Culture Collection (CCTCC, Wuhan, P.R. China) with an access No. of M2016144. The method for the synthesis of 2,5-dihydroxymethylfuran using this strain is described as follows: after pre-cultivation and cultivation, Meyerozyma guilliermondii SC 1103 cells are added into the buffer solutions containing 5-hydroxymethylfurfural and glucose; the biocatalytic reaction is conducted under designated conditions, thus affording 2,5-dihydroxymethylfuran. This disclosure has many advantages such as good selectivity, mild reaction conditions, environmental friendliness, high efficiency, and good yield.

    Synthesis of FDCA and FDCA precursors from gluconic acid derivatives
    28.
    发明授权
    Synthesis of FDCA and FDCA precursors from gluconic acid derivatives 有权

    公开(公告)号：US10087161B2

    公开(公告)日：2018-10-02

    申请号：US15202298

    申请日：2016-07-05

    申请人： Synthetic Genomics, Inc.

    发明人： Spiros Kambourakis ,  Benjamin M. Griffin

    IPC分类号： C07D307/46 ,  C07D307/40 ,  C07D307/68 ,  C12P17/04 ,  C12P7/58

    摘要： The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve performing a chemical dehydration reaction on a gluconic acid derivative in the presence of a dehydration catalyst. In some embodiments the gluconic acid derivative can be 2-dehydro-3-deoxy gluconic acid (DHG) or an ester thereof, 2-ketogluconic acid (2KGA) or an ester thereof, and 5-ketogluconic acid (5KGA) or an ester thereof. The 2,5-furan dicarboxylic acid precursor molecule is thereby synthesized, which can be converted into FDCA. The chemical dehydration can be performed by a variety of acid basic catalysts.