公开(公告)号：US09142400B1

公开(公告)日：2015-09-22

申请号：US13944808

申请日：2013-07-17

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Stephen D. Hersee ,  Seung-Chang Lee ,  Daniel Feezell

IPC: H01L29/06 ,  H01L21/02 ,  H01L27/12

CPC classification number: H01L21/02107 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/02532 ,  H01L21/02538 ,  H01L21/02639 ,  H01L27/1211 ,  H01L29/045 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/66469 ,  H01L29/66795 ,  H01L29/775 ,  H01L29/7783 ,  H01L29/785

Abstract: A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.

Abstract translation: 一种制造异质外延层的方法。 该方法包括提供半导体衬底。 在半导体衬底上形成用选择性生长掩模描绘的种子区域。 种子区域包括第一材料并且具有小于100nm的线性表面尺寸。 在种子区域上生长异质外延层，异质外延层包含不同于第一材料的第二材料。 还公开了通过该方法制造的器件。

公开(公告)号：US09132120B1

公开(公告)日：2015-09-15

申请号：US13783785

申请日：2013-03-04

Applicant: STC.UNM ,  University of Maryland, Baltimore

Inventor： Alan Edward Tomkinson ,  Feyruz Rassool

IPC: A61K31/4184 ,  C40B40/06 ,  A61K31/165

CPC classification number: A61K31/4184 ,  A61K31/00 ,  A61K31/165 ,  A61K45/06 ,  C12Q1/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57434 ,  G06F19/00 ,  G06F19/20 ,  G06F19/3456 ,  Y02A90/26 ,  A61K2300/00

Abstract: In one embodiment, the invention provides a method of treating a subject suffering from a breast cancer tumor which is non-responsive or intrinsically resistant to anti-estrogen therapy comprising administering a therapeutically effective amount of an inhibitor of alternative (ALT) non-homologous end joining (NHEJ) factor to the subject.In another embodiment the invention provides a method of treating a subject who suffers from a pancreatic cancer which is non-responsive to chemotherapy and/or radiation comprising co-administering a therapeutically effective amount of PARP1 inhibitor and a DNA ligase IIIα inhibitor to the subject. Related diagnostic methods, nucleic acid arrays, devices and kits are also provided.

Abstract translation: 在一个实施方案中，本发明提供了治疗患有对抗雌激素疗法无反应或本质上抗性的乳腺癌肿瘤的受试者的方法，其包括施用治疗有效量的替代（ALT）非同源末端的抑制剂 加入（NHEJ）因素。 在另一个实施方案中，本发明提供了治疗患有对化学疗法和/或放射线无反应的胰腺癌的受试者的方法，包括向受试者共同施用治疗有效量的PARP1抑制剂和DNA连接酶IIIα抑制剂。 还提供了相关的诊断方法，核酸阵列，装置和试剂盒。

公开(公告)号：US09106055B2

公开(公告)日：2015-08-11

申请号：US13574550

申请日：2011-01-21

Applicant: Wolfgang G. Rudolph ,  Amarin Ratanavis ,  Vasudevan Nampoothiri ,  Kristan L. Corwin ,  Andrew M. Jones ,  Brian R. Washburn ,  Rajesh Kadel ,  John M. Zavada

Inventor： Wolfgang G. Rudolph ,  Amarin Ratanavis ,  Vasudevan Nampoothiri ,  Kristan L. Corwin ,  Andrew M. Jones ,  Brian R. Washburn ,  Rajesh Kadel ,  John M. Zavada

IPC: H01S3/30 ,  H01S3/223 ,  H01S3/067 ,  H01S3/094 ,  H01S3/0943

CPC classification number: H01S3/223 ,  H01S3/06741 ,  H01S3/094003 ,  H01S3/0943 ,  H01S3/2232

Abstract: Apparatus, systems, and methods using an optically pumped gas filled hollow fiber laser can be implemented in a variety of applications. In various embodiments, operation of an optically pumped gas filled hollow fiber laser is based on population inversion in the gas. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 使用光泵浦气体填充中空纤维激光器的装置，系统和方法可以在各种应用中实现。 在各种实施例中，光泵浦气体填充中空纤维激光器的操作基于气体中的群体反转。 公开了附加装置，系统和方法。

公开(公告)号：US09074977B2

公开(公告)日：2015-07-07

申请号：US14339820

申请日：2014-07-24

Applicant: Steven W Graves ,  Robert W. Applegate, Jr. ,  Gabriel P. Lopez ,  Menake Eranda Piyasena

Inventor： Steven W Graves ,  Robert W. Applegate, Jr. ,  Gabriel P. Lopez ,  Menake Eranda Piyasena

IPC: G01N21/00 ,  G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1459 ,  G01N2015/142

Abstract: An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.

Abstract translation: 提供了诸如流式细胞仪的分析装置，其中流过通道的流体样品通过延伸穿过通道的声波场聚焦成多个平行的颗粒流。 然后将每个流提供给单独的检测器，以允许多个流的同时询问，从而对流体样品进行高通量分析。

公开(公告)号：US09074237B2

公开(公告)日：2015-07-07

申请号：US14111066

申请日：2012-04-12

Applicant: Graham Timmins ,  Terry Wu ,  Seong Won Choi

Inventor： Graham Timmins ,  Terry Wu ,  Seong Won Choi

IPC: C12Q1/34 ,  C12Q1/04 ,  C07C275/16 ,  C07B59/00

CPC classification number: C12Q1/04 ,  C07B59/001 ,  C07B2200/05 ,  C07B2200/07 ,  C07C275/16 ,  C12Q2304/46 ,  C12Q2304/48

Abstract: The present invention is directed to the use of isotopically labeled citrulline for gnosing the presence or absence of a bacterial infection in the lungs of a patient.

Abstract translation: 本发明涉及同位素标记的瓜氨酸用于在患者的肺中发现细菌感染的存在或不存在的用途。

公开(公告)号：US20150187068A1

公开(公告)日：2015-07-02

申请号：US14401827

申请日：2013-03-14

Applicant: Sanjay KRISHNA ,  Sanchita KRISHNA ,  Majeed M. HAYAT ,  Sen PRADEEP ,  Maziar YAESOUBI ,  Sebastian Eugenio GODOY ,  Ajit Vigay BARVE

Inventor： Sanjay Krishna ,  Sanchita Krishna ,  Majeed M. Hayat ,  Pradeep Sen ,  Maziar Yaesoubi ,  Sebastian Eugenio Godoy ,  Ajit Vijay Barve

IPC: G06T7/00 ,  G06K9/62 ,  G06T3/00 ,  G06K9/46

CPC classification number: G06T7/0012 ,  G06F19/00 ,  G06F19/321 ,  G06K9/46 ,  G06K9/4604 ,  G06K9/6267 ,  G06T3/00 ,  G06T3/0068 ,  G06T7/0016 ,  G06T7/30 ,  G06T7/337 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/30088 ,  G06T2207/30096 ,  G06T2207/30204 ,  G16H50/20

Abstract: Apparatus and methods comprise examination of a subject using images of the subject. The images can provide a non-invasive analysis technique and can include a plurality of images of a portion of the subject at different times a temperature stimulus applied to the subject. An image of the portion of the subject can be aligned such that each pixel of the image corresponds to the same point on the subject over a sequence of images of the portion. The sequence of images can be processed after aligning the images such that data is extracted from the images. The extracted data can be used to make decisions regarding the health status of the subject. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 装置和方法包括使用受试者的图像检查受试者。 图像可以提供非侵入性分析技术，并且可以在不同时间包括施加到对象的温度刺激的受试者的一部分的多个图像。 对象的部分的图像可以对准，使得图像的每个像素在该部分的图像序列上对应于被摄体上的相同点。 可以在对准图像之后处理图像序列，使得从图像中提取数据。 提取的数据可用于作出关于受试者的健康状况的决定。 公开了附加装置，系统和方法。

公开(公告)号：US09005575B2

公开(公告)日：2015-04-14

申请号：US13321942

申请日：2010-05-28

Applicant: Yubin Miao ,  Jianquan Yang

Inventor： Yubin Miao ,  Jianquan Yang

IPC: A61K51/00 ,  A61M36/14 ,  C07K14/68 ,  A61K51/08 ,  C12N9/88 ,  A61K38/00

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K51/082 ,  A61K51/086 ,  A61K51/088 ,  C12N9/88

Abstract: The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及新颖的非侵入性诊断和治疗工具/化合物，其包含利用环肽螯合基团的杂环环肽，其中所述化合物结合MSH受体以成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤 体内。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US08908992B1

公开(公告)日：2014-12-09

申请号：US13084781

申请日：2011-04-12

Applicant: Paul A. Rodriguez-Valderrama ,  Marios Stephanou Pattichis ,  Victor Manuel Murray-Herrera

Inventor： Paul A. Rodriguez-Valderrama ,  Marios Stephanou Pattichis ,  Victor Manuel Murray-Herrera

IPC: G06K9/36

CPC classification number: H04N19/60 ,  G06F19/321 ,  G06T5/10

Abstract: An image and video processing system and methods based on amplitude-modulation frequency-modulation (“AM-FM”) demodulation to provide high quality reconstructions, both visually and quantitatively. The system and methods reconstructs an image based on a Regularized Optimization (“RO”) of estimates to attain a small number of locally coherent components and simultaneously enforce a piecewise smooth constrain for one or more amplitude functions.

Abstract translation: 一种基于幅度调制频率调制（“AM-FM”）解调的图像和视频处理系统和方法，以视觉和定量提供高质量的重建。 该系统和方法基于估计的正则化优化（“RO”）重建图像，以获得少量的局部相干分量，同时对一个或多个幅度函数强制分段平滑约束。

公开(公告)号：US20140341352A1

公开(公告)日：2014-11-20

申请号：US14293621

申请日：2014-06-02

Applicant: Shuang Luan ,  Lijun Ma ,  Zhe Chen

Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC: A61N5/10

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg. Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg相反的剂量梯度。 GammaKnife®放射外科手术高峰和跑赢。

公开(公告)号：US08712679B1

公开(公告)日：2014-04-29

申请号：US13284259

申请日：2011-10-28

Applicant: Yasamin Mostofi ,  Pradeep Sen

Inventor： Yasamin Mostofi ,  Pradeep Sen

IPC: G01S13/34 ,  G09B29/00 ,  G05D1/02

CPC classification number: G01S13/89 ,  G01S13/003 ,  G05D1/0274 ,  G05D1/0291 ,  G05D2201/0207 ,  G09B29/00

Abstract: A system and methods for building a map non-invasively (i.e. mapping of occluded and non-occluded obstacles) based on a small number of wireless channel measurements. Approaches for building an obstacle map are based on coordinated space, random space and frequency sampling, such that the sparse representation of the map in space, wavelet or spatial variations, are exploited in order to build the map with minimal sensing.

Abstract translation: 一种用于基于少量无线信道测量非侵入地构建地图（即，闭塞和非遮挡障碍物的映射）的系统和方法。 用于构建障碍物图的方法基于协调空间，随机空间和频率采样，以便利用空间中的地图的稀疏表示，小波或空间变化，以便以最小的感测构建地图。