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1.发明授权Multinode acoustic focusing for parallel flow cytometry analysis applications 有权用于并行流式细胞仪分析应用的多节点声聚焦公开(公告)号：US09074977B2
公开(公告)日：2015-07-07
申请号：US14339820
申请日：2014-07-24
CPC分类号： G01N15/1404 , G01N15/1459 , G01N2015/142
摘要： An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.
摘要翻译： 提供了诸如流式细胞仪的分析装置，其中流过通道的流体样品通过延伸穿过通道的声波场聚焦成多个平行的颗粒流。 然后将每个流提供给单独的检测器，以允许多个流的同时询问，从而对流体样品进行高通量分析。
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2.发明申请Multinode acoustic focusing for parallel flow cytometry analysis applications 有权用于并行流式细胞仪分析应用的多节点声聚焦公开(公告)号：US20140336062A1
公开(公告)日：2014-11-13
申请号：US14339820
申请日：2014-07-24
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1459 , G01N2015/142
摘要： An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.
摘要翻译： 提供了诸如流式细胞仪的分析装置，其中流过通道的流体样品通过延伸穿过通道的声波场聚焦成多个平行的颗粒流。 然后将每个流提供给单独的检测器，以允许多个流的同时询问，从而对流体样品进行高通量分析。
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公开(公告)号：US08465983B1
公开(公告)日：2013-06-18
申请号：US11466046
申请日：2006-08-21
IPC分类号： G01N21/00
CPC分类号： G01N21/00 , C12Q1/18 , G01N33/542 , G01N33/54313 , G01N33/5432 , G01N33/554
摘要： The invention relates to lipid bilayer coated beads and methods of using those beads in delivery systems, in immunoassays, in analytical assays and the like.
摘要翻译： 本发明涉及脂双层包被的珠粒以及在递送系统中，在免疫测定，分析测定等中使用那些珠粒的方法。
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公开(公告)号：US20120271023A1
公开(公告)日：2012-10-25
申请号：US13503067
申请日：2010-10-12
申请人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
发明人： David G. Whitten , Linnea K. Ista , Thomas S. Corbitt , Motokatsu Ogawa , Kirk S. Schanze , Gabriel P. Lopez , Ramanathan Nagarajan
IPC分类号： C08G83/00
CPC分类号： A01N43/90 , D06M13/513 , D06M14/02 , D06M14/04 , D06M14/06 , D06M14/08 , D06M15/227 , D06M16/00 , D06M23/005 , D06M2400/01 , Y10T442/20 , Y10T442/2525 , A01N25/10 , A01N25/34
摘要： The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.
摘要翻译： 本公开描述了软表面的制造和使用，例如带有表面接枝的抗微生物聚合物的织物。
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公开(公告)号：US20110209999A1
公开(公告)日：2011-09-01
申请号：US12930543
申请日：2011-01-10
申请人： Scott S. Sibbett , Gabriel P. Lopez
发明人： Scott S. Sibbett , Gabriel P. Lopez
IPC分类号： G01N27/447 , G01N27/453 , B01D15/08
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/502746 , B01L2300/0825 , B01L2400/0406 , B01L2400/0421 , B01L2400/084 , G01N27/4473
摘要： A lateral flow device includes a porous medium layer having a two-dimensional shape in plan view that is capable of supporting near-constant velocity capillary-driven fluid flow and can be combined with electrodes in a manner to achieve to achieve electrokinetic molecule separation.
摘要翻译： 侧流装置包括在平面图中具有二维形状的多孔介质层，其能够支持接近恒定速度的毛细管驱动的流体流动，并且可以以实现电动分子分离的方式与电极组合。
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6.再颁专利公开(公告)号：USRE42315E1
公开(公告)日：2011-05-03
申请号：US11825298
申请日：2007-07-05
IPC分类号： B01D15/34
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。
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7.发明授权Fabrication of an anisotropic super hydrophobic/hydrophilic nanoporous membranes 有权各向异性超疏水/亲水纳米孔膜的制备公开(公告)号：US07393391B2
公开(公告)日：2008-07-01
申请号：US10969341
申请日：2004-10-21
CPC分类号： B01D69/02 , B01D67/0065 , B01D67/0079 , B01D67/0088 , B01D69/127 , C25D11/045 , C25D11/12 , C25D11/24
摘要： Anisotropic hydrophobic/hydrophilic nanoporous membranes and methods of forming anisotropic hydrophobic/hydrophilic nanoporous membranes are disclosed. The method of forming the nanoporous membrane includes growing a nanoporous oxide film on a substrate. A nanoporous membrane having a top side and a bottom side can then be formed by partially separating the nanoporous oxide film from the substrate. A fluorocarbon film can be deposited on the top side of the nanoporous membrane by plasma polymerization. The disclosed anisotropic hydrophobic/hydrophilic nanoporous membranes can have extremely different hydrophobicity between the top side and the bottom side of the nanoporous membrane.
摘要翻译： 公开了各向异性疏水/亲水纳米多孔膜和形成各向异性疏水/亲水纳米多孔膜的方法。 形成纳米多孔膜的方法包括在衬底上生长纳米多孔氧化物膜。 然后可以通过从纳米孔氧化膜与基底部分分离而形成具有顶侧和底侧的纳米多孔膜。 氟碳膜可以通过等离子体聚合沉积在纳米多孔膜的顶侧。 所公开的各向异性疏水/亲水纳米孔膜可以在纳米多孔膜的顶侧和底侧之间具有非常不同的疏水性。
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8.发明授权Device containing cytophilic islands that adhere cells separated by cytophobic regions 失效包含细胞吸附岛的装置，其附着由细胞疏植区域分离的细胞公开(公告)号：US07067306B2
公开(公告)日：2006-06-27
申请号：US10032280
申请日：2001-12-21
申请人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
摘要翻译： 本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。 该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。 岛或区域或两者可以由自组装单层（SAM）形成。
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公开(公告)号：US07514267B1
公开(公告)日：2009-04-07
申请号：US11466050
申请日：2006-08-21
IPC分类号： G01N21/00
CPC分类号： G01N21/00 , C12Q1/18 , G01N33/542 , G01N33/54313 , G01N33/5432 , G01N33/554
摘要： The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.
摘要翻译： 本发明涉及脂双层包被的珠粒和在免疫测定中使用那些珠粒的方法，在分析测定等中。
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公开(公告)号：US20080317633A1
公开(公告)日：2008-12-25
申请号：US12150607
申请日：2008-04-29
申请人： Scott S. Sibbett , Gabriel P. Lopez
发明人： Scott S. Sibbett , Gabriel P. Lopez
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5027 , B01L2300/025 , B01L2300/0816 , B01L2300/0864 , B32B37/203 , G01N30/92 , Y10T156/1052
摘要： A lateral flow device includes a porous medium layer having a two-dimensional shape in plan view defined by one or more peripheral edges wherein the two dimensional shape includes a plurality of testing regions separated from one another by spaces between portions of the one or more peripheral edges. The porous medium layer further includes a fluid-receiving region in capillary flow communication through the porous medium layer to the testing regions.
摘要翻译： 侧流装置包括具有由一个或多个外围边缘限定的平面图中的二维形状的多孔介质层，其中所述二维形状包括通过所述一个或多个周边部分之间的间隔彼此分开的多个测试区域 边缘。 多孔介质层还包括通过多孔介质层与测试区域进行毛细管流连通的流体接收区域。
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