公开(公告)号：US20160166582A1

公开(公告)日：2016-06-16

申请号：US15050502

申请日：2016-02-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irina LAVELIN ,  Varda ROTTER ,  Moshe OREN ,  Ami NAVON ,  Zvi KAM ,  Benjamin GEIGER

IPC: A61K31/555 ,  G01N33/50 ,  C07K14/47 ,  A61K31/522 ,  A61K31/47

CPC classification number: A61K31/555 ,  A61K31/47 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K33/34 ,  C07K14/4746 ,  C07K2319/40 ,  C07K2319/60 ,  C12N9/6421 ,  C12Y304/25001 ,  G01N33/5035

Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.

公开(公告)号：US20160152991A1

公开(公告)日：2016-06-02

申请号：US15040018

申请日：2016-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yitzhak PILPEL ,  Tamir TULLER ,  Sivan NAVON ,  Menachem RUBINSTEIN

IPC: C12N15/67 ,  C12P21/02

CPC classification number: C12N15/67 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/755 ,  C12N9/2402 ,  C12N9/2465 ,  C12P21/02

Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.

Abstract translation: 公开了分离的多核苷酸，其提高异源细胞中基因表达的效率。 改编编码多肽的多核苷酸序列使得第一至少约30个氨基酸的平均翻译速率比多肽的剩余氨基酸的平均翻译速度慢至少两倍。

公开(公告)号：US09353359B2

公开(公告)日：2016-05-31

申请号：US14140793

申请日：2013-12-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem Sorek ,  Hila Sberro ,  Azita Leavitt

IPC: C07K14/00 ,  C12N9/22 ,  C12N9/12 ,  C07K14/81 ,  A61K38/00

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20160103192A1

公开(公告)日：2016-04-14

申请号：US14893085

申请日：2014-05-20

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Jonathan REINER ,  Lior EMBON ,  Yonathan ANAHORY ,  Yuri MYASOEDOV ,  Eli ZELDOV

IPC: G01R33/035 ,  G01R33/00

CPC classification number: G01R33/0354 ,  G01R33/0052 ,  G01R33/035

Abstract: The present invention discloses a sensor device comprising a probe carrying a three-dimensional magnetic field sensor. The probe has a conical tip portion with an edge being configured as the three-dimensional magnetic field sensor. The sensor at the edge of the tip comprises at least three Josephson junctions, each junction being formed of a superconducting layer interrupted by a barrier. The barrier comprises a non-superconducting layer or a geometrical constriction. The conical tip portion of the probe forms a tapered three-dimensional structure having at least one arc-like part crossing the opening of the tip portion such that the apex has a closed-loop basis and a plurality of complimentary spaced-apart facets defined by the at least one arc, thereby enabling measurement of both in-plane and out-of-plane magnetic fields separately.

Abstract translation: 本发明公开了一种包括携带三维磁场传感器的探头的传感器装置。 探头具有锥形尖端部分，其边缘被配置为三维磁场传感器。 尖端边缘处的传感器包括至少三个约瑟夫逊结，每个连接点由被屏障隔断的超导层形成。 屏障包括非超导层或几何收缩。 探针的锥形尖端部分形成锥形三维结构，其具有至少一个与尖端部分的开口相交的弧形部分，使得顶点具有闭环基和多个互补的间隔开的面，由 所述至少一个电弧，从而能够分别测量平面内和平面外的磁场。

公开(公告)号：US20160069896A1

公开(公告)日：2016-03-10

申请号：US14652425

申请日：2013-12-16

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. COHEN ,  Eytan DOMANY ,  Ittai FATTAL ,  Noam SHENTAL

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  G01N33/564 ,  G01N2800/104 ,  G01N2800/60

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) or scleroderma in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing SLE or scleroderma in a subject.

Abstract translation: 提供了用于诊断受试者系统性红斑狼疮（SLE）或硬皮病的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中的SLE或硬皮病的特异性抗体反应性分布。

公开(公告)号：US20160008390A1

公开(公告)日：2016-01-14

申请号：US14866957

申请日：2015-09-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef SHAUL ,  Peter Tsvetkov ,  Julia Adler

IPC: A61K31/713 ,  C12N15/113 ,  G01N33/50

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/1135 ,  C12N2310/14 ,  C12Q1/025 ,  C12Q1/68 ,  G01N33/5011 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10

Abstract: A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an agent which induces a dissociation of the 26S proteasomal complex into a 20S component and a 19S component to thereby inhibit 26S proteasomal activity, wherein the pharmaceutical agent is devoid of a chemotherapeutic agent.

Abstract translation: 公开了一种治疗癌症的方法。 该方法包括向受试者施用治疗有效量的药物组合物，其包含诱导26S蛋白酶体复合体解离成20S组分和19S组分从而抑制26S蛋白酶体活性的试剂，其中所述药剂没有 化疗剂。

公开(公告)号：US20160000821A1

公开(公告)日：2016-01-07

申请号：US14856697

申请日：2015-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  C12Q1/68 ,  A61K48/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K48/0058 ,  C12N15/113 ,  C12N2310/141 ,  C12Q1/6883 ,  C12Q2600/178

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

Abstract translation: 提供了包含其的微小RNA和组合物，用于治疗和诊断5-羟色胺，肾上腺素，去甲肾上腺素，谷氨酸和促肾上腺皮质激素释放激素相关的医疗条件。

公开(公告)号：US20150362737A1

公开(公告)日：2015-12-17

申请号：US14762823

申请日：2014-01-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Barak ZACKAY ,  Avishay GAL-YAM ,  Eran OFEK ,  Sagi BEN AMI

IPC: G02B27/10 ,  G06T7/00 ,  G02B27/12 ,  H04N5/232

CPC classification number: G02B27/1066 ,  G02B23/00 ,  G02B27/123 ,  G06T7/11 ,  H04N5/23212 ,  H04N5/23238

Abstract: An imaging method and system are provided, being particularly useful for imaging a relatively wide field of regard on a relatively small detection surface with high spatial resolution. The method comprises: creating a segmented image of a field of regard in an effective object plane, said image being formed by an array of N image parts of the field of regard; and projecting a selected number M≧1 of patterns of structured light onto a detection surface, which is located in a plane conjugate to the effective object plane and has geometry and size substantially of the image part, each of the M patterns being formed by selected K light components of said N image parts concurrently projected onto the entire detection surface forming a superposition of the K image parts, thereby enabling reconstruction of the image of the field of regard from detected number M of patterns of the structured light.

Abstract translation: 提供了一种成像方法和系统，其特别适用于在具有高空间分辨率的相对小的检测表面上对相对宽的视场进行成像。 该方法包括：在有效对象平面中创建视场的分割图像，所述图像由所述视场的N个图像部分的阵列形成; 并且将选定数量M≥1的结构光图案投影到检测表面上，所述检测表面位于与有效物体平面共轭的平面中并具有基本上为图像部分的几何形状和尺寸，每个M图案由选定的 所述N个图像部分的K个光分量同时投射到整个检测表面上，形成K个图像部分的叠加，从而能够从结构化光的图案的检测数量M重新构建该视场的图像。

公开(公告)号：US20150355139A1

公开(公告)日：2015-12-10

申请号：US14762081

申请日：2014-01-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Ron NAAMAN ,  Maria TKACHEV ,  Anand Kumar TATIKONDA ,  Eyal CAPUA

IPC: G01N27/414 ,  G01N33/543 ,  H01L21/02 ,  H01L29/20 ,  H01L21/306

CPC classification number: G01N27/4145 ,  G01N27/4148 ,  G01N33/54373 ,  H01L21/02118 ,  H01L21/02282 ,  H01L21/30612 ,  H01L29/20

Abstract: The present invention provides semiconductor devices, particularly devices based on the Molecular Controlled Semiconductor Resistor (MOCSER), which are highly stable in aqueous solutions. The semiconductor devices of the invention may be used for the detection of various target molecules, e.g., proteins, peptides, carbohydrates and small molecules, in different solutions such as physiological solution, bodily fluids and bodily fluid-based solutions.

Abstract translation: 本发明提供半导体器件，特别是基于分子控制半导体电阻器（MOCSER）的器件，其在水溶液中是高度稳定的。 本发明的半导体器件可用于在诸如生理溶液，体液和基于体液的溶液之类的不同溶液中检测各种靶分子，例如蛋白质，肽，碳水化合物和小分子。

公开(公告)号：US20150297693A1

公开(公告)日：2015-10-22

申请号：US14754835

申请日：2015-06-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Johannes HERKEL ,  Irun R. COHEN ,  Varda ROTTER ,  Ansgar W. LOHSE ,  Neta EREZ ,  Avishai MIMRAN ,  Na'aman KAM

IPC: A61K39/00

CPC classification number: A61K39/0008 ,  A61K38/00 ,  A61K39/0005 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435

Abstract: The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides.

Abstract translation: 本发明涉及能够抑制真核细胞中的细胞和免疫应答反应的肽。 本发明提供了利用这些肽治疗人退行性疾病和炎症的组合物和方法。