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    Number coding for identification of subtypes of coded types of solid phase carriers
    31.
    发明授权
    Number coding for identification of subtypes of coded types of solid phase carriers 有权
    用于识别编码类型的固相载体亚型的编号

    公开(公告)号：US07927796B2

    公开(公告)日：2011-04-19

    申请号：US10943760

    申请日：2004-09-17

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  G01N33/543 ,  G01N15/06 ,  G01N33/48

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

    Abstract translation: 披露了提供给定类型的这种载体的可区分子类型的固相载体的对（“双”）或小集（“多重”）的数字编码，其中每种载体类型基于不同的代码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因 通过知道多少载体与检测每​​个不同等位基因的分子相关联来区分颜色代码。

    MICROPARTICLES WITH ENHANCED COVALENT BINDING CAPACITY AND THEIR USES
    32.
    发明申请
    MICROPARTICLES WITH ENHANCED COVALENT BINDING CAPACITY AND THEIR USES 有权
    具有增强的合金结合能力的微波炉及其用途

    公开(公告)号：US20100331213A1

    公开(公告)日：2010-12-30

    申请号：US12795198

    申请日：2010-06-07

    Applicant: Xinwen Wang ,  Sukanta Banerjee

    Inventor： Xinwen Wang ,  Sukanta Banerjee

    IPC: C40B40/06 ,  C40B40/00 ,  C40B40/04 ,  C40B50/00

    CPC classification number: C12Q1/6834 ,  C07H21/04 ,  G01N33/54353 ,  C12Q2563/119

    Abstract: A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.

    Abstract translation: 具有多个暴露的官能团的聚电解质，每个这样的基团能够共价键合到分子，固定在表面上用于与生物分子结合的目的。 生物分子可以是例如核酸，例如胺官能化的寡核苷酸。 聚电解质可以包括例如BSA（牛血清白蛋白），其使用共价固定策略结合到官能化表面，例如与甲苯磺酰基活化的微粒的表面反应。 在这样的反应之后，蛋白质上暴露的反应性官能团如胺，羧基，硫醇，羟基可进一步用于使用合适的化学物质共价连接感兴趣的寡核苷酸。

    Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments
    34.
    发明授权
    Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments 有权
    通过捕获由双链靶片段产生的单链DNA进行多重核酸分析的试剂盒

    公开(公告)号：US07790380B2

    公开(公告)日：2010-09-07

    申请号：US11437246

    申请日：2006-05-19

    Applicant: Jiacheng Yang

    Inventor： Jiacheng Yang

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6827 ,  C12Q2565/519 ,  C12Q2523/107

    Abstract: A method of fragmentation of double stranded DNA is disclosed for use in nucleic acid analysis, notably in the multiplexed analysis of polymorphisms and mutations. The method produces a multiplicity of labeled sense and anti-sense fragments which are not complementary, and thus do not significantly re-anneal under conditions suitable for hybridization analysis (or capture-mediated elongation analysis) of the polymorphisms and/or mutations. The fragments display a desired or predicted length distribution. Cleavage sites can be selected such that the fragments are short, yet long enough to allow discrimination among fragments in an assay, and as a matter of statistical probability, such that the majority of fragments contain at least one labeled nucleotide to facilitate detection.

    Abstract translation: 公开了用于核酸分析的双链DNA的断裂方法，特别是在多态性和突变的多重分析中。 该方法产生多个标记的有义和反义片段，其不互补，因此在适合于多态性和/或突变的杂交分析（或捕获介导的延伸分析）的条件下不显着再退火。 片段显示所需或预测的长度分布。 可以选择切割位点使得片段短，但足够长以允许分析中片段之间的区别，并且作为统计概率，使得大多数片段含有至少一个标记的核苷酸以便于检测。

    Microparticles with enhanced covalent binding capacity and their uses
    35.
    发明授权
    Microparticles with enhanced covalent binding capacity and their uses 有权
    具有增强的共价结合能力的微粒及其用途

    公开(公告)号：US07732575B2

    公开(公告)日：2010-06-08

    申请号：US11695686

    申请日：2007-04-03

    Applicant: Xinwen Wang ,  Sukanta Banerjee

    Inventor： Xinwen Wang ,  Sukanta Banerjee

    IPC: C07K17/00 ,  C07H21/04 ,  C12Q1/68

    CPC classification number: C12Q1/6834 ,  C07H21/04 ,  G01N33/54353 ,  C12Q2563/119

    Abstract: Disclosed are proteins which are covalently bound to a solid support at a first temperature where they have a first configuration, and then biomolecules are attached to the bound proteins at a higher temperature at which the proteins have more exposed functional groups, each such group being capable of covalently bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, including an amine functionalized oligonucleotide. The proteins can include, BSA (Bovine Serum Albumin) which can be bound using a reaction with the surface of a tosyl-activated microparticle.

    Abstract translation: 公开了在第一温度下共价结合固体支持物的蛋白质，其中它们具有第一构型，然后生物分子在蛋白质具有更多暴露的官能团的较高温度下连接到结合的蛋白质上，每个这样的基团能够 共价结合到生物分子上。 生物分子可以是例如核酸，包括胺官能化的寡核苷酸。 蛋白质可以包括可与甲苯磺酰基活化的微粒表面反应结合的BSA（牛血清白蛋白）。

    Primers for exons of variants of RHCE and RHD genes
    37.
    发明授权
    Primers for exons of variants of RHCE and RHD genes 有权
    RHCE和RHD基因变体外显子的引物

    公开(公告)号：US07612193B2

    公开(公告)日：2009-11-03

    申请号：US12206859

    申请日：2008-09-09

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    IPC: C07H21/04 ,  C12N15/12

    CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16

    Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

    Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。

    Analysis, secure access to, and transmission of array images
    38.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07526114B2

    公开(公告)日：2009-04-28

    申请号：US10714203

    申请日：2003-11-14

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Tandem repeat determination by concurrent analysis of multiple tandem duplex configurations
    39.
    发明授权
    Tandem repeat determination by concurrent analysis of multiple tandem duplex configurations 有权
    通过并行分析多个串联双工配置进行串联重复确定

    公开(公告)号：US07202038B2

    公开(公告)日：2007-04-10

    申请号：US10913987

    申请日：2004-08-06

    Applicant: Michael Seul

    Inventor： Michael Seul

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q2525/186 ,  C12Q2533/101 ,  C12Q2535/101 ,  C12Q2565/102

    Abstract: Disclosed is a method of analyzing tandem repeats using one or more probes, each such probe may lack an anchoring sequence but contains one or more tandem repeat sequences complementary to the target tandem repeat sequences. In one embodiment, each probe is attached, via its 5′ end, to an encoded microparticle (“bead”), wherein the code—implemented by way of a color scheme—identifies the sequence and length of the probe attached thereto. Also disclosed are methods relating to the analysis of partial duplex configurations involving only partial overlap between probe and target repeats and thus “overhangs” of probe repeats on the 3′ and/or 5′ ends of the target repeats.

    Abstract translation: 公开了使用一个或多个探针分析串联重复序列的方法，每个这样的探针可能缺少锚定序列，但是含有与靶序列重复序列互补的一个或多个串联重复序列。 在一个实施方案中，每个探针通过其5'末端连接到编码的微粒（“珠粒”），其中通过配色方案代码实现 - 识别附着于其上的探针的序列和长度。 还公开了与仅涉及探针和目标重复之间部分重叠的部分双相结构分析相关的方法，因此在目标重复的3'和/或5'末端上的探针重复“突出”。

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