公开(公告)号：US5326452A

公开(公告)日：1994-07-05

申请号：US917013

申请日：1992-10-06

Applicant: Gjerloff Roed ,  Niels D. Linnet

Inventor： Gjerloff Roed ,  Niels D. Linnet

IPC: A61B5/145 ,  A61B5/1477 ,  C03C4/18 ,  G01N27/36 ,  G01N27/404 ,  G01N27/26

CPC classification number: G01N27/36

Abstract: The glass electrode comprises a membrane of ion sensitive glass. The membrane comprises a composite material consisting of a matrix of ion sensitive glass and a dispersed filling material therein having higher tensile strength than the matrix. The membrane of the glass electrode is particularly resistant to mechanical stress and the glass electrode is i.a. applicable in a tc Pco.sub.2 electrode of the Severinghaus-type.

Abstract translation: PCT No.PCT / DK91 / 00031 Sec。 371日期：1992年10月6日 102（e）日期1992年10月6日PCT 1991年2月4日PCT PCT。 公开号WO91 / 12523 日期：1991年8月22日。玻璃电极包括离子敏感玻璃膜。 膜包括由离子敏感玻璃基质和其中分散的填充材料组成的复合材料，其具有比基体更高的拉伸强度。 玻璃电极的膜特别耐机械应力，玻璃电极是i.a. 适用于Severinghaus型的tc Pco2电极。

公开(公告)号：USD325259S

公开(公告)日：1992-04-07

申请号：US454122

申请日：1989-12-21

Applicant: Joergen Andersen ,  Ib O. Sinnerup ,  Kristian J. Hvidtfeldt

Designer： Joergen Andersen ,  Ib O. Sinnerup ,  Kristian J. Hvidtfeldt

公开(公告)号：US4686012A

公开(公告)日：1987-08-11

申请号：US914550

申请日：1986-10-01

Applicant: John E. Engell ,  Svend Mortensen

Inventor： John E. Engell ,  Svend Mortensen

IPC: G01N27/30 ,  C04B35/447 ,  G01N27/333 ,  H01M6/18 ,  G01N27/46

CPC classification number: C04B35/447 ,  C04B35/16 ,  C04B35/481 ,  C04B35/624 ,  C04B35/62655 ,  G01N27/333 ,  H01M6/185 ,  C04B2235/3201 ,  C04B2235/3217 ,  C04B2235/3244 ,  C04B2235/3418 ,  C04B2235/3427 ,  C04B2235/441 ,  C04B2235/447 ,  C04B2235/5409 ,  C04B2235/77 ,  C04B2235/80 ,  C04B2235/81

Abstract: An ion-sensitive measuring electrode device with an ion-sensitive element based on ion-conducting crystalline ceramic material is provided. The electrode device shows a selectivity to the Na.sup.+ ion versus the H.sup.+ ion corresponding to the selectivity of the known sodium-sensitive glass-based solid membrane electrodes.Ion-sensitive measuring electrode devices showing good selectivity properties are provided on the basis of ion-conducting crystalline material, the crystal structure of which comprises a three-dimensionally extending interstitial space containing positions for the ion, especially material in which the interstitial space has bottlenecks which just permits passage of the ion.A method for preparing polycrystalline ceramic material based on oxides of zirconium, phosphor and silicon is also provided.

Abstract translation: 提供了一种具有离子传导结晶陶瓷材料的离子敏感元件的离子敏感测量电极装置。 对于已知的钠敏感的玻璃基固体膜电极的选择性，电极装置显示对Na +离子相对于H +离子的选择性。 显示出良好选择性的离子敏感测量电极器件是基于离子导电晶体材料提供的，离子导电晶体材料的晶体结构包括三维延伸的间隙空间，其包含用于离子的位置，特别是间隙空间具有瓶颈的材料 这只允许离子通过。 还提供了一种基于锆，磷和硅的氧化物制备多晶陶瓷材料的方法。

公开(公告)号：US4685465A

公开(公告)日：1987-08-11

申请号：US709027

申请日：1985-01-24

Applicant: Peter C. Klitgaard ,  Knud G. Pedersen

Inventor： Peter C. Klitgaard ,  Knud G. Pedersen

IPC: G01N27/404 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0408 ,  A61B5/0448 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/145 ,  A61B5/1477 ,  G01N27/403 ,  G01N33/49

CPC classification number: A61B5/1477 ,  A61B5/04004 ,  A61B5/0448 ,  A61B5/14542 ,  A61B5/4362

Abstract: An electrode device for transcutaneously measuring the blood gas parameter and for sensing a bioelectrical signal and an electrode assembly comprising such an electrode device are disclosed. The electrode assembly for transcutaneously measuring a blood gas parameter and for measuring a bioelectrical signal comprises two separate electrode devices one of which further comprises an electrochemical measuring electrode system. The electrochemical measuring electrode system comprises a reference electrode of a potentiometric electrode system and an anode of a polarographic electrode system constituted by a single metallic body, a pH-electrode of the potentiometric electrode system, and a noble metal cathode of the polarographic electrode system. By means of the electrode assembly, coincident measurement of the blood gas partial pressures of oxygen and carbon dioxide and of a bioelectrical signal such as the ECG (Electrocardiography), the RR (Respiration rate) or the heart rate of the test person or patient is obtainable.

Abstract translation: PCT No.PCT / DK84 / 00048 Sec。 371日期1985年1月24日 102（e）日期1985年1月24日PCT提交1984年5月24日PCT公布。 出版物WO84 / 04815 日本1984年12月6日。公开了一种用于经皮测量血气参数并用于感测生物电信号的电极装置和包括这种电极装置的电极组件。 用于经皮测量血气参数和用于测量生物电信号的电极组件包括两个单独的电极装置，其中一个电极装置还包括电化学测量电极系统。 电化学测量电极系统包括电位电极系统的参比电极和由单一金属体，电位电极系统的pH电极和极谱电极系统的贵金属阴极构成的极谱电极系统的阳极。 通过电极组件，氧气和二氧化碳的血气分压和生物电信号（ECG（心电图）），测试人或患者的RR（呼吸率）或心率的一致测量是 可获得。

公开(公告)号：US3972614A

公开(公告)日：1976-08-03

申请号：US487368

申请日：1974-07-10

Applicant: Ebbe Johansen ,  Finn Chresten Lundsgaard

Inventor： Ebbe Johansen ,  Finn Chresten Lundsgaard

IPC: A61B5/145 ,  G01N33/483 ,  G03B27/76 ,  G03B27/52

CPC classification number: G02B26/008 ,  G01N1/286 ,  G01N2001/4094

Abstract: The invention relates to a method and apparatus for measuring one or more data of blood samples, such as oxygen saturation, contents of hemoglobin, bicarbonate, sodium, potassium, etc. involving hemolyzation of the blood sample. The blood sample is passed into a conduit and hemolyzed therein by imparting ultra-sonic waves to all parts defining said conduits. Measurement is performed after and possibly also prior to hemolyzation. In its preferred embodiment the apparatus according to the invention comprises a computer for automatically controlling the operational sequence of the components of the apparatus and for receiving measuring signals from measuring devices of the apparatus and converting said signals into immediately understandable digital data.

Abstract translation: 本发明涉及一种用于测量血液样本的一个或多个数据的方法和装置，例如氧饱和度，血红蛋白含量，碳酸氢钠，钠，钾等，涉及血液样品的溶血。 血液样品通过向限定所述导管的所有部分施加超声波而被引入导管并在其中溶血。 在血液溶解之后进行测量。 在其优选实施例中，根据本发明的装置包括用于自动控制装置的部件的操作顺序的计算机，以及用于从该装置的测量装置接收测量信号并将所述信号转换为立即可理解的数字数据。

公开(公告)号：US5443077A

公开(公告)日：1995-08-22

申请号：US90156

申请日：1993-07-23

Applicant: Soren-Christian Krogh ,  Erik Aksbro

Inventor： Soren-Christian Krogh ,  Erik Aksbro

IPC: A61B5/00 ,  A61B5/06 ,  G01B7/00 ,  G01V3/10

CPC classification number: A61B5/1477 ,  A61B5/06 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1491

Abstract: When performing the method a sensor (1) is used with a coil (15) integrated in a coil circuit. In the coil circuit a magnetic field is generated so that mutual induction can develop between the coil circuit and the surroundings of the sensor (1). The magnetic field in the coil circuit is detected intermittently, and a developed mutual induction is detected as a change of the magnetic field. The position of the sensor is monitored on the basis of said intermittent detection of the magnetic field in the coil circuit. The change of the magnetic field in the coil circuit can be detected in several ways. If the magnetic field is varying, the change may for example be detected as a change of the peak value of the voltage across or the current intensity through the coil circuit or be detected as a phase shift of one of these parameters. The method is used especially to ensure that calibration of the sensor (1) is performed only when the sensor (1) is located in a related calibration chamber (24). The detectable mutual induction is developed between the coil circuit with the coil (15) and an aluminum cup (22) constituting the calibration chamber (24).

Abstract translation: PCT No.PCT / DK92 / 00014 Sec。 371日期：1993年7月23日 102（e）日期1993年7月23日PCT提交1992年1月21日PCT公布。 公开号WO92 / 12670 日期为1992年8月6日。当执行该方法时，传感器（1）与集成在线圈电路中的线圈（15）一起使用。 在线圈电路中产生磁场，使得线圈电路和传感器（1）的周围之间可以产生互感。 线圈电路中的磁场被间歇地检测，并且显影的互感被检测为磁场的变化。 基于线圈电路中的所述磁场的间歇检测来监测传感器的位置。 线圈电路中的磁场变化可以用几种方法来检测。 如果磁场发生变化，则该变化例如可以被检测为通过线圈电路的电压峰值或电流强度的变化，或者被检测为这些参数之一的相移。 该方法特别用于确保仅当传感器（1）位于相关校准室（24）中时才执行传感器（1）的校准。 在与线圈（15）的线圈电路和构成校准室（24）的铝杯（22）之间形成可检测的互感。

公开(公告)号：US5425868A

公开(公告)日：1995-06-20

申请号：US97377

申请日：1993-07-23

Applicant: Knud G. Pedersen

Inventor： Knud G. Pedersen

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491

Abstract: The sensor (1) comprises a sensor body (3) thermostatable by means of a first thermostating system (14,15) and having an outer surface (3a,40a) for application to the human body (28) in heat conductive relationship therewith, said outer surface (3a,40a) forming the measuring surface of the sensor (1). The sensor (1) further comprises analyte sensing means (7,8) arranged in said sensor body (3) and being thermostated through said body (3) by means of the first thermostating system (14,15). The sensor (1) further comprises means (16,41) arranged in the sensor body (3) in heat insulated relationship therewith while in heat conductive relationship with a delimited surface part of the sensor measuring surface (3a,40a). The means (16,41) is thermostatable by means of a second thermostating system. The delimited surface part is located within the outer periphery of the sensor measuring surface (3a,40a).

Abstract translation: 传感器（1）包括通过第一恒温系统（14,15）可热调节的传感器主体（3），并且具有用于与人体（28）导热关系的外表面（3a，40a） 所述外表面（3a，40a）形成所述传感器（1）的测量表面。 传感器（1）还包括布置在所述传感器主体（3）中并通过第一恒温系统（14,15）通过所述主体（3）恒温的分析物传感装置（7,8）。 传感器（1）还包括与热传导关系的传感器主体（3）中布置的与传感器测量表面（3a，40a）的限定表面部分的导热关系的装置（16,41）。 装置（16,41）可通过第二恒温系统进行热稳定。 限定的表面部分位于传感器测量表面（3a，40a）的外周边内。

公开(公告)号：US5417121A

公开(公告)日：1995-05-23

申请号：US180605

申请日：1994-01-13

Applicant: Joergen Andersen ,  Kristian J. Hvidtfeldt ,  Ib O. Sinnerup

Inventor： Joergen Andersen ,  Kristian J. Hvidtfeldt ,  Ib O. Sinnerup

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1002 ,  G01N2035/1006 ,  G01N35/1079

Abstract: New apparatus for measuring parameters such as pH, pCO.sub.2, pO.sub.2, and Hb content of physiological fluids, especially blood, is described. The apparatus comprises novel means for suspending reagent vessels (34, 35, 40, 45, 50) having shoulders (51, 52) and containing calibrating solutions, rinsing solutions etc., as well as for suspending a liquid waste vessel (26) by suspending the vessels between rods (53, 54) fed to the analyser. The reagent vessels are provided with caps (55, 58) at the top and include liquid reagent conduit extending from the outlet aperture of the cap down into the liquid. When the vessel is mounted on the analyser a fixed inlet tube extending horizontally outwardly from the analyser penetrates a seal across the outlet aperture and connects with the liquid reagent conduit.

Abstract translation: 描述了用于测量诸如生理液体，特别是血液的pH，pCO 2，pO 2和H b含量的参数的新装置。 该装置包括用于悬挂具有肩部（51,52）并包含校准溶液，漂洗溶液等的试剂容器（34,35,40,45,50）的新颖装置，以及用于将液体废物容器（26）悬浮在 将容器悬挂在馈送到分析器的杆（53,54）之间。 试剂容器在顶部设置有帽（55,58），并且包括从帽的出口孔向下延伸到液体中的液体试剂导管。 当容器安装在分析器上时，从分析仪水平向外延伸的固定入口管穿过出口孔并穿过液体试剂导管连接。

公开(公告)号：US5371020A

公开(公告)日：1994-12-06

申请号：US050100

申请日：1993-05-07

Applicant: Peter A. Frischauf

Inventor： Peter A. Frischauf

IPC: G01N21/05 ,  G01N21/03 ,  G01N21/31 ,  G01N35/10

CPC classification number: G01N21/0303 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2035/1062 ,  G01N21/314 ,  G01N2201/0662

Abstract: A method of photometric in vitro determination of the content of an analyte in a sample is disclosed. The sample is located in a measuring chamber which has a radiation path length and has at least one at least partially transparent wall part. The measuring chamber is in optical communication with an optical system adapted for the analyte which includes a radiation source and a radiation detector. The measuring chamber is adjustable in shape which enables the radiation path length across the measuring chamber to be changed. In a first measuring step an unknown first radiation path length across the measuring chamber is set and radiation at at least two wavelengths is transmitted from the radiation source through the measuring chamber and to the radiation detector. In a second step, the measuring chamber is adjusted in shape thereby setting a second unknown path length across the measuring chamber. Radiation at the same wavelengths as during the first step is again transmitted from the radiation source through the measuring chamber and to the radiation detector. The analyte content is then determined on the basis of radiation detected in each of the measuring steps.

Abstract translation: PCT No.PCT / DK92 / 00280 Sec。 371日期：1993年5月7日 102（e）日期1993年5月7日PCT 1991年9月17日PCT公布。 出版物WO93 / 06456 日期：1993年4月1日。公开了一种光度测定样品中分析物含量的方法。 样品位于具有辐射路径长度并具有至少一个至少部分透明的壁部分的测量室中。 测量室与适用于包括辐射源和辐射探测器的分析物的光学系统光学通信。 测量室的形状可调节，使测量室上的辐射路径长度可以改变。 在第一测量步骤中，设置跨越测量室的未知的第一辐射路径长度，并且至少两个波长的辐射从辐射源通过测量室和辐射探测器传输。 在第二步骤中，测量室的形状被调节，从而在测量室上设置第二未知路径长度。 与第一步骤相同的波长的辐射再次从辐射源通过测量室和辐射探测器传输。 然后基于在每个测量步骤中检测到的辐射来确定分析物含​​量。

公开(公告)号：US5114859A

公开(公告)日：1992-05-19

申请号：US689727

申请日：1991-04-22

Applicant: Henrik Kagenow

Inventor： Henrik Kagenow

IPC: B01L3/00 ,  G01N27/28 ,  G01N33/487 ,  G01N35/00

CPC classification number: B01L3/502 ,  B01L3/508 ,  G01N35/00594 ,  B01L2400/0478 ,  B01L2400/0683 ,  G01N35/00693 ,  Y10T436/115831

Abstract: A method and apparatus for measuring a characteristic which is a function of the concentration of one or more chemical species in a sample fluid, examples being the concentration of sodium ion or potassium ion in blood, makes use of a discardable or disposable measuring device comprising one or more sensors, an example of a relevant type of sensor being a potentiometric electrode, one or more conditioning (e.g. calibration) fluid chambers and, optionally, a sample fluid chamber, the sensor(s) being movable relative to the chamber(s), or vice versa, so as permit conditioning of the sensor(s) in a conditioning fluid chamber and exposure of a sensing surface part of the sensor(s) to a sample fluid.

Abstract translation: 用于测量作为样品流体中的一种或多种化学物质的浓度的函数的特性的方法和装置，例如血液中的钠离子或钾离子的浓度，使用可丢弃的或一次性的测量装置，其包括一个 或更多的传感器，作为电位计电极的相关类型的传感器的示例，一个或多个调节（例如校准）流体室和可选的样品流体室，所述传感器可相对于腔室移动， ，或反之亦然，以便允许调节调节流体室中的传感器并将传感器的感测表面部分暴露于样品流体。