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    Intravascular stent and method of use
    33.
    发明授权
    Intravascular stent and method of use 有权
    血管内支架及其使用方法

    公开(公告)号：US08657871B2

    公开(公告)日：2014-02-25

    申请号：US13887682

    申请日：2013-05-06

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Timothy A. Limon

    IPC: A61F2/06

    CPC classification number: A61F2/06 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/828 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054

    Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.

    Abstract translation: 将可扩张的支架植入体腔，例如冠状动脉，外周动脉或其他体腔，用于治疗易损斑块的区域。 本发明提供一种血管内支架，其具有通过波浪形连杆连接的多个圆柱形环。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。 中心部分定位在远端和近端部分之间，并与脆性斑块的区域对准，以增强内皮细胞在易损斑块的纤维帽上的生长，以加强该区域并降低破裂的可能性。

    INTRAVASCULAR STENTS
    38.
    发明申请
    INTRAVASCULAR STENTS 审中-公开
    胸腔镜手术

    公开(公告)号：US20130030516A1

    公开(公告)日：2013-01-31

    申请号：US13644735

    申请日：2012-10-04

    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC

    Inventor： Andy E. Denison

    IPC: A61F2/06

    CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  Y10T29/49826

    Abstract: Stent designs for use in vessels, such as the carotid and coronary arteries, are disclosed. The stents consist of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in a longitudinal direction. The cylindrical elements form a generally serpentine wave pattern transverse to the longitudinal axis between alternating valley portions and peak portions. The interconnecting members are attached to the double-curved portions to connect a cylindrical element to an adjacent cylindrical element and interconnecting members are attached to the inverted double-curved portions to connect the cylindrical element to the other adjacent cylindrical element. The stent designs include both a six crown and an eight crown stent which exhibit flexibility and sufficient radial strength to support the vessel.

    Abstract translation: 公开了用于血管的支架设计，例如颈动脉和冠状动脉。 支架由多个可径向扩张的圆柱形元件组成，其大体上在公共的纵向支架轴线上对准，并且通过一个或多个相互连接的构件相互连接，以使支架在纵向方向上是柔性的。 圆柱形元件在交替的谷部分和峰部分之间形成横向于纵向轴线的大致蛇形波形图案。 互连构件附接到双弯曲部分以将圆柱形元件连接到相邻的圆柱形元件，并且互连构件附接到倒置的双曲面部分，以将圆柱形元件连接到另一相邻圆柱形元件。 支架设计包括六冠和八冠支架，其展现出柔韧性和足够的径向强度以支撑血管。

    Method of sterilizing a medical device
    39.
    发明申请
    Method of sterilizing a medical device 有权
    医疗器械消毒方法

    公开(公告)号：US20030083616A1

    公开(公告)日：2003-05-01

    申请号：US10002933

    申请日：2001-11-01

    Applicant: Advanced Cardiovascular Systems, Inc.

    Inventor： Jeong S. Lee ,  Kenneth L. Wantink

    IPC: A61M029/00

    CPC classification number: A61L2/087 ,  A61L2202/24 ,  A61M25/10

    Abstract: A method of sterilizing a medical device component, such as a catheter balloon, in which an electron beam (i.e., e-beam) is applied to the component in an evacuated or inert gas-filled container. The method of the invention allows for electron beam sterilization without significant degradation of the component polymeric material. In one embodiment, the device component is configured to be pressurized or expanded during use. The method of the invention provides a component with a rupture pressure that is not significantly decreased due to electron beam sterilization. Another aspect of the invention is a medical device component, e-beam sterilized according to a method of the invention. A variety of medical device components can be sterilized by the method of the invention, and particularly intracorporeal devices for therapeutic or diagnostic purposes, such as balloon catheters, catheter shafts and balloons, stent covers, and vascular grafts.

    Abstract translation: 对在真空或惰性气体填充的容器中的组件施加电子束（即电子束）的医疗装置部件（例如导管球囊）进行灭菌的方法。 本发明的方法允许电子束灭菌而不会显着降低组分聚合物材料。 在一个实施例中，装置部件构造成在使用期间被加压或膨胀。 本发明的方法提供了由于电子束灭菌而没有显着降低的断裂压力的部件。 本发明的另一方面是根据本发明的方法消毒的电子束的医疗装置部件。 可以通过本发明的方法，特别是用于治疗或诊断目的的体内器件，例如球囊导管，导管轴和球囊，支架盖和血管移植物来消毒各种医疗装置部件。

    Catheter with a polyimide distal tip
    40.
    发明申请
    Catheter with a polyimide distal tip 有权
    导管与聚酰亚胺的远端

    公开(公告)号：US20030055448A1

    公开(公告)日：2003-03-20

    申请号：US09957593

    申请日：2001-09-19

    Applicant: Advanced Cardiovascular systems, Inc.

    Inventor： Jeong S. Lee ,  Edwin Wang

    IPC: A61M029/00

    CPC classification number: A61M25/10 ,  A61L29/085 ,  A61L2420/08 ,  A61M25/001 ,  A61M25/0045 ,  A61M25/0069 ,  A61M2025/1093 ,  C08L79/08 ,  C08L77/00 ,  C08L77/12 ,  C08L75/04

    Abstract: A catheter having an elongated shaft which has a multilayered distal tip with a first layer formed of a polyimide first material and a second layer formed of a polymeric second material. In one embodiment the multilayered distal tip is a separate member, distal to the distal end of a proximal portion of the shaft. In another embodiment, the shaft has an outer tubular member, and a multilayered inner tubular member with a distal end which forms the multilayered distal tip of the shaft. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. In one embodiment, the polymeric second material is a polyamide material.

    Abstract translation: 一种具有细长轴的导管，该细长轴具有由聚酰亚胺第一材料形成的第一层和由聚合物第二材料形成的第二层的多层远端。 在一个实施例中，多层远侧末端是远离轴的近端部分的远端的分离的构件。 在另一个实施例中，轴具有外部管状构件和多层内部管状构件，其具有形成轴的多层远侧末端的远端。 在目前优选的实施方案中，聚酰亚胺材料是热固性聚酰亚胺。 在一个实施方案中，聚合物第二材料是聚酰胺材料。

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