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公开(公告)号：US20230382958A1
公开(公告)日：2023-11-30
申请号：US18245249
申请日：2021-09-10
发明人： Richie Pei Kun Tay , Siak Wei OW
IPC分类号： C07K14/335 , C12N9/02
CPC分类号： C07K14/335 , C12N9/0089 , A61K38/00
摘要： The invention relates generally to the field of molecular biology and microbiology. Provided herein is an expression construct encoding a fusion protein. In one embodiment, there is provided an expression construct encoding a fusion protein, the expression construct comprising a nucleic acid encoding a first polypeptide for expression and a second polypeptide derived from the cell wall targeting region of a Lactobacillus plantarum Lys2 autolysin, wherein the first and second polypeptides are joined to form a fusion protein. In a specific embodiment, the second polypeptide comprises the CAD4a domain, which is a truncated domain containing only R1-R3 of the five-repeat SH3_5 domain of the Lys2 autolysin. Provided herein is also a fusion protein and the use of a fusion protein as defined herein.
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公开(公告)号：US11814290B2
公开(公告)日：2023-11-14
申请号：US16651107
申请日：2018-09-27
IPC分类号： C01B32/162 , C01B32/168 , B01J23/00 , B01J23/755 , B01J37/02 , B01J37/03 , B01J37/04 , B01J37/08 , B01J37/18
CPC分类号： C01B32/162 , B01J23/005 , B01J23/755 , B01J37/0236 , B01J37/036 , B01J37/04 , B01J37/088 , B01J37/18 , C01B32/168 , C01B2202/06 , C01B2202/36 , C01P2002/72 , C01P2002/88 , C01P2004/04
摘要： A method for the synthesis of carbon nanotubes from natural rubber, including providing a first material, the first material may include natural rubber or derivatives thereof, thermally decomposing the first material at a first temperature into an intermediate material, contacting the intermediate material with a catalyst, treating the intermediate material in contact with the catalyst at a second temperature, for forming carbon nanotubes. Adjusting an average characteristic of resulting nanotubes, including carrying out the synthesis method as a reference method and for decreasing the average diameter of the nanotube: decreasing the second temperature and/or decreasing the reaction time and/or increasing the concentration of H2 in the forming gas in relation to the reference method. Or, for increasing the average diameter of the nanotube: increasing the second temperature and/or increasing the reaction time and/or decreasing the concentration of H2 in the forming gas in relation to the reference method.
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33.发明公开公开(公告)号：US20230356223A1
公开(公告)日：2023-11-09
申请号：US18195918
申请日：2023-05-10
发明人： Shireen GOH , Shan Mei TAN
CPC分类号： B01L3/502753 , B01D21/265 , B01D43/00 , B01L3/502707 , B01L3/50273 , B01L3/502776 , B04B5/10 , C12M23/16 , C12M29/10 , C12M33/14 , C12M47/02 , B01L2200/027 , B01L2200/0652 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/088 , B01L2400/0403 , B03B5/32
摘要： An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.
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公开(公告)号：US20230354840A1
公开(公告)日：2023-11-09
申请号：US18246135
申请日：2020-09-21
发明人： Pui Yeu Phoon
CPC分类号： A23D9/04 , A23D9/007 , A23D7/0056
摘要： The present invention relates to a method for the manufacture of an oleogel, comprising a) homogenising an aqueous dispersion of natural food fibre to develop viscosity, b) shear-mixing the aqueous fibre dispersion with liquid edible oil at room temperature to form an emulsion, and c) subjecting the emulsion to freeze-drying to remove the water. In some embodiments, the natural food fibre is citrus fibre or nata de coco fibre mix. The invention further relates to an edible fibre-based oleogel obtained by the method, as well as food products comprising the oleogel and/or based upon the oleogel.
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35.发明公开公开(公告)号：US20230351195A1
公开(公告)日：2023-11-02
申请号：US18042718
申请日：2020-08-31
发明人： Ming Ming WONG , Sumit Bam SHRESTHA , Vishnu PARAMASIVAM , Aarthy MANI , Wenyu JIANG , Anh Tuan DO
摘要： There is provided a neurosynaptic processing core with spike time dependent plasticity (STDP) learning for a spiking neural network, including: a spiking neuron block including a pre-synaptic block and a post-synaptic block; a synapse block communicatively coupled to the spiking neuron block; a STDP learning block communicatively coupled to the spiking neuron block and the synapse block, the STDP learning block including a pre-synaptic event accumulator including a pre-synaptic spike event memory block and a pre-synaptic spike parameter modifier; a post-synaptic event accumulator including a post-synaptic spike event memory block and a post-synaptic spike parameter modifier, a weight change accumulator, and a weight change parameter modifier; a learning error modulator; and a synaptic weight modifier configured to modify a synaptic weight parameter based on a weight change parameter and a learning error corresponding to the synaptic weight parameter. There is also provided a corresponding method of operating and a corresponding method of forming the neurosynaptic processing core.
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公开(公告)号：US20230348436A1
公开(公告)日：2023-11-02
申请号：US17780235
申请日：2020-11-26
IPC分类号： C07D403/12 , A61K31/4709 , A61K31/506 , A61P31/06
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/506 , A61P31/06
摘要： The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.
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37.发明公开公开(公告)号：US20230326127A1
公开(公告)日：2023-10-12
申请号：US18023108
申请日：2021-08-26
发明人： Liang ZHONG , Weimin HUANG , Junmei ZHANG , Gaurav CHANDOLA , Soo Teik LIM , Ru San TAN , Swee Yaw TAN
CPC分类号： G06T17/00 , G06T7/0012 , G06T7/10 , G06T7/62 , G06T7/64 , G06T7/66 , G06V10/46 , G06T2207/10081 , G06T2207/30101
摘要： Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.
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公开(公告)号：US20230320707A1
公开(公告)日：2023-10-12
申请号：US17926714
申请日：2021-06-11
发明人： Kun Liang , Kit Mun Cheryl Leong
CPC分类号： A61B10/0233 , B33Y80/00 , B29C33/42
摘要： The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.
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39.发明授权公开(公告)号：US11780908B2
公开(公告)日：2023-10-10
申请号：US17066092
申请日：2020-10-08
CPC分类号： C07K16/1081 , A61P31/12 , A61K2039/505 , C07K2317/52 , C07K2317/56 , C07K2317/734 , C07K2317/92 , C07K2317/94 , Y02A50/30
摘要： The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in a parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1 q-binding activity when compared to the parent Fc region.
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公开(公告)号：US20230313308A1
公开(公告)日：2023-10-05
申请号：US17713143
申请日：2022-04-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , Singapore Health Services Pte Ltd , National University Hospital (Singapore) Pte Ltd , Tan Tock Seng Hospital Pte Ltd , MiRXES Lab Pte. Ltd.
发明人： Siew Gek Lee-Lim , Ruiyang Zou , Lihan Zhou , He Cheng , Bo Anders Mikael Hartman , Heng-Phon Too
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , C12Q2600/158 , C12Q2600/118
摘要： This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.
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