公开(公告)号：US09066670B2

公开(公告)日：2015-06-30

申请号：US13387492

申请日：2010-08-03

Applicant: Gil Cohen ,  Dan Hashimshony ,  Iddo Geltner ,  Harel Golombek

Inventor： Gil Cohen ,  Dan Hashimshony ,  Iddo Geltner ,  Harel Golombek

IPC: G01R27/04 ,  A61B5/053 ,  A61B5/05

CPC classification number: A61B5/053 ,  A61B5/05 ,  A61B2560/04 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/227

Abstract: A sensor unit for use in measurements on a subject is presented. The sensor unit includes a near field electromagnetic sensor and a flexible signal transmission structure, which are integral with one another by means of at least one common continuous surface. The flexible signal transmission structure is constructed from a first layer including signal connection lines associated with sensor cells near field electromagnetic sensor and a second electrically conductive layer electrically coupled to the electrically conductive material of the sensor.

Abstract translation: 介绍了一种用于测量对象的传感器单元。 传感器单元包括通过至少一个公共连续表面彼此成一体的近场电磁传感器和柔性信号传输结构。 柔性信号传输结构由包括与传感器单元近场电磁传感器相关联的信号连接线的第一层和与传感器的导电材料电耦合的第二导电层构成。

公开(公告)号：US20140098376A1

公开(公告)日：2014-04-10

申请号：US14123249

申请日：2012-06-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: G01N33/483

CPC classification number: G01N33/4833 ,  A61B10/00 ,  A61B10/02 ,  A61B2034/107 ,  G01N1/06 ,  G01N1/286 ,  G16H40/63

Abstract: A probe device for use in a tissue inspection system is presented. The probe device comprises a probe body and a control unit at least partially incorporated in the probe body. The probe body carries at least a tissue characterization unit operable for providing sensing data indicative of at least one tissue property at measurement locations in the tissue portion being held by the probe. The control unit comprises: a processor utility for receiving and processing the sensing data and generating measured data indicative of a spatial profile of said at least one tissue property distribution within the tissue portion, and comprises at least one of the following: an imaging utility for receiving said measured data and generating and displaying an image indicative thereof thereby enabling a user to select a region of said tissue portion for further analysis; and a pattern generator module configured for receiving and analyzing said measured data and determining a pattern indicative of an arrangement of regions in said tissue portion, thereby enabling selection of at least one of the regions for further analysis.

Abstract translation: 提出了一种用于组织检测系统的探针装置。 探针装置包括探针体和至少部分地结合在探针体内的控制单元。 探针体携带至少一个组织表征单元，其可操作用于提供感测数据，该感测数据指示由探针保持的组织部分中的测量位置处的至少一个组织属性。 控制单元包括：处理器实用程序，用于接收和处理感测数据，并产生指示组织部分内的所述至少一个组织属性分布的空间分布的测量数据，并且包括以下中的至少一个：用于 接收所述测量数据并产生和显示指示其的图像，从而使用户能够选择所述组织部分的区域用于进一步分析; 以及图案生成器模块，被配置为接收和分析所述测量数据并且确定指示所述组织部分中的区域布置的图案，由此能够选择所述区域中的至少一个用于进一步分析。

公开(公告)号：US08449477B2

公开(公告)日：2013-05-28

申请号：US10582135

申请日：2006-03-02

Applicant: Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Orit Yarden ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/00

CPC classification number: A61B10/0096 ,  A01N1/02 ,  A01N1/0273 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2090/0807 ,  A61B2090/0811 ,  A61B2090/3908 ,  B01L3/508 ,  G01N1/312

Abstract: A device and method are provided for tissue handling, while maintaining the in-vivo tissue orientation. The device includes a structure, configured for receiving and holding a tissue specimen, wherein the tissue specimen includes tissue positional references; and device positional references, associated with the structure, for fixing the orientation of the tissue specimen, when held by the device, so as to reflect the tissue specimen positional references.

Abstract translation: 提供了用于组织处理的装置和方法，同时保持体内组织取向。 所述装置包括构造成用于接收和保持组织样本的结构，其中所述组织样本包括组织位置参考; 以及与所述结构相关联的用于固定所述组织样本的取向的装置位置参考，当被所述装置保持时，以便反映所述组织样本位置参考。

公开(公告)号：US20090253978A1

公开(公告)日：2009-10-08

申请号：US12483738

申请日：2009-06-12

Applicant: Dan HASHIMSHONY ,  Orit YARDEN ,  Gal AHARONOWITZ ,  Gil COHEN

Inventor： Dan HASHIMSHONY ,  Orit YARDEN ,  Gal AHARONOWITZ ,  Gil COHEN

IPC: A61B5/00 ,  G06F3/048 ,  G01M19/00

CPC classification number: A61B5/05 ,  A61B5/0084 ,  A61B5/015 ,  A61B5/053 ,  A61B5/06 ,  A61B5/064 ,  A61B8/0858 ,  A61B8/12 ,  A61B34/20 ,  A61B34/25 ,  A61B34/30 ,  A61B2090/061 ,  A61B2562/0233 ,  A61B2562/046 ,  G06F3/0481 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481 ,  G16H40/63 ,  G16H50/50

Abstract: A graphical user interface (GUI) including: (a) a group definition module adapted to accept a user input defining groups; (b) a data receiver operable to receive a plurality of individual measurement input datum indicative of status of a substrate; (c) a grouping module configured to assign each of said individual measurement input datum to one of said groups to produce grouped data; and (d) an output module adapted to output the grouped data.

Abstract translation: 一种图形用户界面（GUI），包括：（a）适合于接受定义组的用户输入的组定义模块; （b）数据接收器，用于接收指示衬底状态的多个单独的测量输入数据; （c）分组模块，其被配置为将每个所述个体测量输入数据分配给所述组中的一个以产生分组数据; 和（d）适于输出分组数据的输出模块。

公开(公告)号：US20070255169A1

公开(公告)日：2007-11-01

申请号：US11743028

申请日：2007-05-01

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B17/00 ,  A61B17/32

CPC classification number: A61B5/0507 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/015 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/4312 ,  A61B5/4381 ,  A61B8/4245

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US20060264738A1

公开(公告)日：2006-11-23

申请号：US11487431

申请日：2006-07-17

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B5/05

CPC classification number: G01R33/60 ,  A61B5/053 ,  A61B5/055 ,  A61B10/0266 ,  A61B90/39 ,  G01R33/3808 ,  G06F19/00

Abstract: A method and apparatus are disclosed, for examining a substance of a given volume to characterize its type, with an integrated sensing head. The method comprises applying locally to the substance of the given volume a polarizing magnetic field, with a component defining a polarizing axis; applying locally RF pulses to the substance of the given volume, the RF pulses having a B component, orthogonal to the polarizing axis, such as to invoke EI response signals corresponding to the electrical impedance (EI) of the examined substance of the given volume, and magnetic resonance (MR) response signals corresponding to the MR properties of the examined substance of the given volume; detecting locally EI response signals from the substance of the given volume; and detecting locally MR response signals from the substance of the given volume. Two or more sensing heads may be used, both applying locally the RF pulses and detecting. Alternatively, one of the sensing heads may operate as a transmitter, while the other or others may operate as receivers.

Abstract translation: 公开了一种用于通过集成感测头来检查给定体积的物质来表征其类型的方法和装置。 该方法包括将局部施加给给定体积的物质的偏振磁场，其中限定偏振轴的分量; 将本地RF脉冲施加到给定体积的物质，RF脉冲具有与偏振轴正交的B分量，以便调用与给定体积的被检物质的电阻抗（EI）相对应的EI响应信号， 和对应于给定体积的检查物质的MR性质的磁共振（MR）响应信号; 从给定体积的物质中检测局部EI响应信号; 以及从给定体积的物质检测局部MR响应信号。 可以使用两个或更多个感测头，两个或更多个感测头都本地施加RF脉冲和检测。 或者，感测头中的一个可以作为发射器操作，而另一个或另外一个可以作为接收器操作。

公开(公告)号：US20050021019A1

公开(公告)日：2005-01-27

申请号：US10891750

申请日：2004-07-15

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B5/053 ,  A61B5/055 ,  A61B10/00 ,  A61B10/02 ,  A61B19/00 ,  A61B18/04

CPC classification number: G01R33/60 ,  A61B5/053 ,  A61B5/055 ,  A61B10/0266 ,  A61B90/39 ,  G01R33/3808

Abstract: A method and apparatus for examining a substance volume to characterize its type, particularly useful for examining tissue to characterize it as cancerous or non-cancerous, by: applying a polarizing magnetic field through the examined substance: applying RF pulses locally to the examined substance volume such as to invoke electrical impedance (EI) responses signals corresponding to the electrical impedance of the substance, and magnetic resonance (MR) responses signals corresponding to the MR properties of the substance; detecting the EI and MR response signals; and utilizing the detected response signals for characterizing the examined substance volume type.

Abstract translation: 用于检查物质体积以表征其类型的方法和装置，特别可用于通过以下方式检查组织以表征其为癌性或非癌性：通过检查的物质施加极化磁场：将RF脉冲局部施加到被检物质体积 例如调用对应于物质的电阻抗的电阻抗（EI）响应信号，以及对应于物质的MR性质的磁共振（MR）响应信号; 检测EI和MR响应信号; 以及利用检测到的响应信号来表征所检查的物质体积类型。

公开(公告)号：US09757098B2

公开(公告)日：2017-09-12

申请号：US13547950

申请日：2012-07-12

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/02 ,  A61B17/3205 ,  A61B17/00

CPC classification number: A61B10/0275 ,  A61B17/3205 ,  A61B2017/00026 ,  A61B2017/00039 ,  A61B2017/00057

Abstract: A medical device including a tissue characterization probe having an elongated carrier for carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier within at least a distal portion thereof, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array. The elongated carrier has two integral portions including said distal portion and a hollow portion extending between a proximal end of the carrier and said distal portion. The carrier is configured for passing a predetermined treatment tool through the hollow portion thereof and enabling at least a part of the treatment tool to project from the hollow portion and extend along the distal portion.

公开(公告)号：US09498192B2

公开(公告)日：2016-11-22

申请号：US13387504

申请日：2010-08-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B10/02 ,  A61B10/06

CPC classification number: A61B10/0266 ,  A61B5/05 ,  A61B5/0538 ,  A61B10/0275 ,  A61B10/06 ,  A61B2505/05 ,  A61B2562/227

Abstract: A surgical tool for use in a tissue removal procedure from a subject is described. The surgical tool has proximal and distal regions and at least one sensor for sensing one or more predetermined conditions located at a distal region of the surgical tool. And a substantially flat signal transmission structure electrically connected with the at least one sensor and extending between the location at the distal region and the proximal region. The signal transmission structure is configured for providing impedance controlled signal transmission between the at least one sensor and the proximal region.

Abstract translation: 描述了用于来自受试者的组织去除程序的外科手术工具。 外科手术工具具有近端和远端区域和至少一个传感器，用于感测位于手术工具的远端区域的一个或多个预定条件。 以及基本平坦的信号传输结构，与所述至少一个传感器电连接并且在所述远端区域和所述近侧区域之间的位置之间延伸。 信号传输结构被配置用于在至少一个传感器和近端区域之间提供阻抗控制的信号传输。

公开(公告)号：US09301734B2

公开(公告)日：2016-04-05

申请号：US12663923

申请日：2008-07-13

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B17/00 ,  A61B18/14 ,  A61B19/00 ,  A61B10/02 ,  A61B5/00

CPC classification number: A61B10/0233 ,  A61B5/00 ,  A61B10/0266 ,  A61B90/37 ,  A61B2017/00022 ,  A61B2017/00128 ,  A61B2017/00199 ,  A61B2018/1475 ,  A61B2090/061

Abstract: A medical device is presented for use in tissue characterization and treatment. The device comprises: a tissue characterization probe comprising an elongated carrier carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array, thereby enabling consequent treatment of the abnormal tissue specimen by a treatment tool.

Abstract translation: 呈现用于组织表征和治疗的医疗装置。 所述装置包括：组织表征探针，其包括细长载体，所述细长载体承载至少沿着所述载体的轴线以间隔关系布置的组织表征传感器阵列，使得所述探针通过组织块的进展提供定位和确定 基于来自阵列中的传感器的特征信号，所述组织块内部的异常组织标本的尺寸，从而能够通过治疗工具进行异常组织标本的治疗。