公开(公告)号：US5736625A

公开(公告)日：1998-04-07

申请号：US468970

申请日：1995-06-06

Applicant: Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

Inventor： Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

IPC: A61K47/48 ,  C07H5/06 ,  C07H13/04 ,  C07H15/12 ,  C07K16/12 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/58 ,  C07K1/00 ,  C12N1/06 ,  C12N9/96 ,  G01N33/536

CPC classification number: C07H5/06 ,  A61K47/48176 ,  A61K47/4843 ,  A61K47/48692 ,  C07H13/04 ,  C07H15/12 ,  C07K16/1292 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/581 ,  Y10S530/816

Abstract: A method is disclosed for preparing water soluble protein polymer conjugates which stabilize the protein so as to retain functional properties in a hostile environment. The method comprises covalently bonding the polymer to the protein through at least three linkers which linkers have three or more hydroxyl groups. The protein is conjugated at lysines or arginines.

Abstract translation: 公开了一种制备稳定蛋白质以在敌对环境中保持功能性质的水溶性蛋白质聚合物共轭物的方法。 该方法包括通过至少三个连接体具有三个或更多个羟基共价键将聚合物与蛋白质结合。 蛋白质在赖氨酸或精氨酸缀合。

公开(公告)号：US5691154A

公开(公告)日：1997-11-25

申请号：US469662

申请日：1995-06-06

Applicant: Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

Inventor： Matthew R. Callstrom ,  Mark D. Bednarski ,  Patrick R. Gruber

IPC: A61K47/48 ,  C07H5/06 ,  C07H13/04 ,  C07H15/12 ,  C07K16/12 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/58 ,  G01N33/53 ,  C12N9/00 ,  C12N9/96

CPC classification number: C07H5/06 ,  A61K47/48176 ,  A61K47/4843 ,  A61K47/48692 ,  C07H13/04 ,  C07H15/12 ,  C07K16/1292 ,  C07K16/44 ,  C08F8/30 ,  C08F8/34 ,  C12N11/06 ,  C12N11/08 ,  G01N33/545 ,  G01N33/581 ,  Y10S530/816

Abstract: An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups.

Abstract translation: 公开了酶联免疫测定法的改进，其中酶是在恶劣环境中稳定的水溶性聚合物糖共轭物的形式。 缀合物包含通过糖连接基团在多个点与聚合物连接的酶。

公开(公告)号：US5247059A

公开(公告)日：1993-09-21

申请号：US935566

申请日：1992-08-24

Applicant: Patrick R. Gruber ,  Eric S. Hall ,  Jeffrey J. Kolstad ,  Matthew L. Iwen ,  Richard D. Benson ,  Ronald L. Borchardt

Inventor： Patrick R. Gruber ,  Eric S. Hall ,  Jeffrey J. Kolstad ,  Matthew L. Iwen ,  Richard D. Benson ,  Ronald L. Borchardt

IPC: C08G63/06 ,  C08G63/08

CPC classification number: C08G63/08 ,  C08G63/06

Abstract: A process for the continuous production of substantially purified lactide and lactide polymers from an ester of lactic acid including the steps of forming crude lactide in the presence of a catalyst means to form a condensation reaction by-product and polylactic acid and depolymerizing the polylactic acid molecules followed by subsequent purification of the crude lactide in a distillation system. A purified lactide is then polymerized.

Abstract translation: 一种从乳酸酯连续制备基本上纯化的丙交酯和丙交酯聚合物的方法，包括在催化剂存在下形成粗丙交酯的步骤，以形成缩合反应副产物和聚乳酸，并解聚聚乳酸分子 随后在蒸馏系统中随后纯化粗丙交酯。 然后将纯化的丙交酯聚合。

公开(公告)号：US20130261323A1

公开(公告)日：2013-10-03

申请号：US13902119

申请日：2013-05-24

Applicant: Matthew W. Peters ,  Joshua D. Taylor ,  David E. Henton ,  Leo E. Manzer ,  Patrick R. Gruber ,  Josefa M. Griffith ,  Yassin Al Obaidi

Inventor： Matthew W. Peters ,  Joshua D. Taylor ,  David E. Henton ,  Leo E. Manzer ,  Patrick R. Gruber ,  Josefa M. Griffith ,  Yassin Al Obaidi

IPC: C07C1/24 ,  C07D301/19 ,  C07C45/53 ,  C07C37/50 ,  C07C45/28 ,  C07C51/16 ,  C07C67/08 ,  C07C67/00 ,  C07C407/00 ,  C07C37/20

CPC classification number: C07C1/24 ,  C07C9/16 ,  C07C11/02 ,  C07C11/167 ,  C07C15/02 ,  C07C15/04 ,  C07C15/08 ,  C07C37/20 ,  C07C37/50 ,  C07C45/28 ,  C07C45/53 ,  C07C51/16 ,  C07C67/00 ,  C07C67/08 ,  C07C407/00 ,  C07D301/19 ,  C10G3/00 ,  C10G29/205 ,  C10G50/00 ,  C10G69/12 ,  Y02P20/52 ,  Y02P30/20 ,  C07C11/04 ,  C07C11/08

Abstract: Isobutene, isoprene, and butadiene are obtained from mixtures of C4 and/or C5 olefins by dehydrogenation. The C4 and/or C5 olefins can be obtained by dehydration of C4 and C5 alcohols, for example, renewable C4 and C5 alcohols prepared from biomass by thermochemical or fermentation processes. Isoprene or butadiene can be polymerized to form polymers such as polyisoprene, polybutadiene, synthetic rubbers such as butyl rubber, etc. in addition, butadiene can be converted to monomers such as methyl methacrylate, adipic acid, adiponitrile, 1,4-butadiene, etc. which can then be polymerized to form nylons, polyesters, polymethylmethacrylate etc.

Abstract translation: 异丁烯，异戊二烯和丁二烯通过脱氢从C4和/或C5烯烃的混合物中获得。 C4和/或C5烯烃可以通过C4和C5醇的脱水获得，例如通过热化学或发酵方法由生物质制备的可再生的C4和C5醇。 异戊二烯或丁二烯可以聚合形成聚合物，如聚异戊二烯，聚丁二烯，合成橡胶如丁基橡胶等。此外，丁二烯可以转化成单体如甲基丙烯酸甲酯，己二酸，己二腈，1,4-丁二烯等 然后将其聚合形成尼龙，聚酯，聚甲基丙烯酸甲酯等

公开(公告)号：US08304588B2

公开(公告)日：2012-11-06

申请号：US13344464

申请日：2012-01-05

Applicant: William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

Inventor： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC: C07C29/76

CPC classification number: C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

公开(公告)号：US20090226990A1

公开(公告)日：2009-09-10

申请号：US12263436

申请日：2008-10-31

Applicant: Andrew C. Hawkins ,  David A. Glassner ,  Thomas Buelter ,  James Wade ,  Peter Meinhold ,  Matthew W. Peters ,  Patrick R. Gruber ,  William A. Evanko ,  Aristos A. Aristidou

Inventor： Andrew C. Hawkins ,  David A. Glassner ,  Thomas Buelter ,  James Wade ,  Peter Meinhold ,  Matthew W. Peters ,  Patrick R. Gruber ,  William A. Evanko ,  Aristos A. Aristidou

IPC: C12P7/16 ,  C12N1/21 ,  C07H21/04

CPC classification number: C12P7/16 ,  C07K14/245 ,  C10G1/04 ,  C10G2300/1014 ,  C10G2300/4025 ,  C10L1/02 ,  C10L2200/0469 ,  C10L2290/26 ,  C12N9/0006 ,  C12N9/0036 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/2428 ,  C12N9/2434 ,  C12P7/04 ,  C12P7/24 ,  C12P7/62 ,  C12Y106/01002 ,  C12Y302/01001 ,  C12Y302/01003 ,  Y02E50/10 ,  Y02E50/16 ,  Y02P30/20

Abstract: Methods for producing a biofuel are provided. Also provided are biocatalysts that convert a feedstock to a biofuel.

Abstract translation: 提供生产生物燃料的方法。 还提供了将原料转化为生物燃料的生物催化剂。

公开(公告)号：US06217630B1

公开(公告)日：2001-04-17

申请号：US09303703

申请日：1999-05-03

Applicant: Michael J. Chanen ,  Bernhard George van Bommel ,  Patrick R. Gruber

Inventor： Michael J. Chanen ,  Bernhard George van Bommel ,  Patrick R. Gruber

IPC: C05C900

CPC classification number: C05G3/0047 ,  C05C9/00

Abstract: A conditioned fertilizer product is provided. The conditioned fertilizer product includes urea containing fertilizer and lactic acid derived conditioning agent. The conditioning agent is preferably included at a concentration of between about 0.1% by wt. and about 5% by wt. The conditioning agent is preferably lactic acid, lactide, and/or polylactide. A method for conditioning fertilizer is provided including a step of mixing urea containing fertilizer and conditioning agent at a temperature of between about 135° C. and about 145° C. A method for using conditioned fertilizer product is provided.

Abstract translation: 提供有条件的肥料产品。 调理肥料包括含有肥料的尿素和乳酸衍生的调理剂。 调理剂优选以约0.1重量％的浓度包含。 和约5重量％。 调理剂优选为乳酸，丙交酯和/或聚丙交酯。 提供了一种调理肥料的方法，包括在约135℃至约145℃的温度下混合含有肥料和调理剂的尿素的步骤。提供了使用调理肥料的方法。

公开(公告)号：US5585191A

公开(公告)日：1996-12-17

申请号：US527705

申请日：1995-09-13

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan ,  Eric S. Hall ,  Robin S. Eichen Conn

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan ,  Eric S. Hall ,  Robin S. Eichen Conn

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  B32B27/36 ,  B32B9/04

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: An amorphous film comprised of a lactide polymer. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 2 percent and water in concentration of less than about 2000 parts-per-million. A process for manufacturing an amorphous film with the lactide polymer composition is also disclosed.

公开(公告)号：US5539081A

公开(公告)日：1996-07-23

申请号：US445775

申请日：1995-05-22

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Eric S. Hall ,  Robin S. Eichen Conn ,  Christopher M. Ryan

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.

公开(公告)号：US5536807A

公开(公告)日：1996-07-16

申请号：US110394

申请日：1993-08-23

Applicant: Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan

Inventor： Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Christopher M. Ryan

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  B32B9/04 ,  B32B27/36

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A semi-crystalline film comprised of a lactide polymer. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 5 percent and water in concentration of less than about 2000 parts-per-million. A process for manufacturing a semi-crystalline film with the lactide polymer composition is also disclosed.