公开(公告)号：US20190038584A1

公开(公告)日：2019-02-07

申请号：US15904153

申请日：2018-02-23

Applicant: The Arizona Board of Regents on Behalf of the University of Arizona ,  The Regents of the University of California, a California Corporation

Inventor： Eugene W. GERNER ,  Jason A. ZELL ,  Christine E. MCLAREN ,  Frank L. MEYSKENS, Jr. ,  Hoda ANTON-CULVER ,  Particia A. THOMPSON

IPC: A61K31/198 ,  G01N33/574 ,  C12Q1/6886 ,  A61K31/192 ,  A61K31/415

Abstract: The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.

公开(公告)号：US10164242B2

公开(公告)日：2018-12-25

申请号：US14716501

申请日：2015-05-19

Applicant: Massachusetts Institute of Technology ,  The Regents of the University of Michigan ,  The Regents of the University of California

Inventor： Yet-Ming Chiang ,  Chang-Jun Bae ,  John William Halloran ,  Qiang Fu ,  Antoni P. Tomsia ,  Can K. Erdonmez

IPC: H01M4/139 ,  H01M10/0525 ,  H01M4/13 ,  H01M4/04 ,  H01M4/1391 ,  H01M10/052 ,  H01M4/02

Abstract: Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries, and can include low tortuosity in the primary direction of ion transport during charge and discharge of the battery. In some embodiments, the electrodes can have a high volume fraction of electrode active material (i.e., low porosity). The attributes outlined above can allow the electrodes to be fabricated with a higher energy density, higher capacity per unit area of electrode (mAh/cm2), and greater thickness than comparable electrodes while still providing high utilization of the active material in the battery during use. Accordingly, the electrodes can be used to produce batteries with high energy densities, high power, or both compared to batteries using electrodes of conventional design with relatively highly tortuous pores.

公开(公告)号：US20180078612A1

公开(公告)日：2018-03-22

申请号：US15830898

申请日：2017-12-04

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Joseph A. Zasadzinski ,  Norbert O. Reich ,  Gary B. Braun ,  Demosthenes P. Morales ,  Xiao Huang

IPC: A61K38/17 ,  C12N15/113

CPC classification number: A61K38/1767 ,  A61K47/6455 ,  A61K47/6923 ,  C12N15/113 ,  C12N2310/14

Abstract: This disclosure describes, in one aspect, a composition for intracellular delivery of a polypeptide. Generally, the composition includes a substrate that has a surface, a cleavable linker affixed to at least a portion of the surface, and a cargo polypeptide bound to the cleavable linker. In some embodiments, the cargo polypeptide can further include a targeting peptide. In another aspect, this disclosure describes a method for intracellular delivery of a polypeptide. Generally, the method includes administering to a subject any embodiments of the composition summarized above, and cleaving the cleavable linker, thereby releasing the cargo polypeptide from the substrate.

公开(公告)号：US09415181B2

公开(公告)日：2016-08-16

申请号：US14071881

申请日：2013-11-05

Applicant: The Regents of The University of Michigan ,  The Regents of the University of California

Inventor： Joel L. Kileny ,  Jeffrey Plott ,  Albert J. Shih ,  Lance Patak ,  Kevin Tremper ,  Daniel Edward Lee

IPC: A61M16/06 ,  A61B1/00 ,  A61M16/04 ,  A61M16/08 ,  A61B1/267

CPC classification number: A61M16/06 ,  A61B1/00154 ,  A61B1/00165 ,  A61B1/267 ,  A61M16/0488 ,  A61M16/0816

Abstract: A face mask that may be used for bag-mask ventilation, during the induction of general anesthesia for example, and allows for two-handed or ambidextrous use. The face mask includes a dome connected to a deformable rim, which forms an enclosed air space when the rim is pressed against a patient's face. The dome has a connection port and a contoured outer surface adjacent the connection port. The contoured outer surface includes contour features such as a pair of crossed composite recesses which may each receive a different one of a user's thumbs. The connection port is aligned with the patient's mouth when the mask is in use and an adapter may be included that attaches to the connection port and provides a ventilation port as well as an intubation port that is aligned with the mouth.

Abstract translation: 可以用于口罩通气的面罩，例如在全身麻醉的诱导期间，并且允许双手或双手使用。 面罩包括连接到可变形边缘的圆顶，当轮辋压靠患者的脸部时，该圆顶形成封闭的空气空间。 圆顶具有连接端口和邻近连接端口的轮廓外表面。 轮廓外表面包括轮廓特征，例如一对交叉的复合凹槽，其可以各自接收用户拇指中的不同的一个。 当使用面罩时，连接端口与患者的口对齐，并且可以包括连接到连接端口并提供通气口的适配器以及与嘴对齐的插管口。

公开(公告)号：US20160166621A1

公开(公告)日：2016-06-16

申请号：US15047906

申请日：2016-02-19

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： Melanie J. Boileau ,  Kenneth D. Clinkenbeard ,  Rinosh Joshua Mani ,  John J. Iandolo ,  Huda Mussa

IPC: A61K35/74 ,  A61K9/00 ,  A61K9/19 ,  C12N1/20

CPC classification number: A61K35/74 ,  A61K9/0048 ,  A61K9/0073 ,  A61K9/19 ,  A61K47/36 ,  A61K47/38 ,  A61K2035/11 ,  C12N1/20

Abstract: Compositions and methods for treating and/or preventing bacterial infections in animals such as bovines are provided. The compositions and methods utilize the predatory bacterium Bdellovibrio bacteriovorus to treat and/or prevent infections such as infectious bovine keratoconjunctivitis (IBK) and bovine respiratory disease (BRD). Use of the bacterium obviates the need for chemotherapeutic measures.

Abstract translation: 提供了用于治疗和/或预防动物如牛中的细菌感染的组合物和方法。 组合物和方法利用掠食性细菌Bdellovibrio bacteriovorus来治疗和/或预防感染如感染性牛角膜结膜炎（IBK）和牛呼吸道疾病（BRD）。 细菌的使用不需要化学治疗措施。

公开(公告)号：US20160140316A1

公开(公告)日：2016-05-19

申请号：US14942493

申请日：2015-11-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Brennan M.R. Spiegel ,  William D. Chey

IPC: G06F19/00

CPC classification number: G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/20 ,  G16H80/00

Abstract: The present disclosure is generally related to automatically evaluating medical patient symptoms and, more specifically, to systems and methods for providing tailored prescriptions, multi-dimensional patient matching and symptom monitoring. In particular, a medical patient completes a questionnaire, responses to the questionnaire are correlated with information obtained from a medical knowledge resource and an integrated symptoms summary is generated based on the responses to the questionnaire and the information obtained from the medical knowledge resource. A tailored prescription is provided to the patient based on the integrated symptoms summary and physician consultation (if applicable), patients are compared to other patients according to questionnaire responses so that they can connect with each other if they chose, and patients are able to monitor symptoms over time so that they can gain insight into whether treatments are working.

Abstract translation: 本公开通常涉及自动评估医疗患者症状，更具体地涉及用于提供定制处方，多维患者匹配和症状监测的系统和方法。 特别地，医疗病人完成问卷，对问卷的响应与从医学知识资源获得的信息相关联，并且基于对问卷的答复和从医学知识资源获得的信息来生成综合症状概要。 根据综合症状总结和医师咨询（如果适用）向患者提供量身定制的处方，根据问卷回答将患者与其他患者进行比较，以便如果他们选择，他们可以相互联系，患者能够监测 症状随时间推移，以便他们能够深入了解治疗是否正常。

公开(公告)号：US09320734B2

公开(公告)日：2016-04-26

申请号：US14589360

申请日：2015-01-05

Applicant: Board of Regents, The University of Texas System ,  Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Daruka Mahadevan ,  Emmanuelle J. Meuillet ,  Eugene A. Mash, Jr. ,  Vijay M. Gokhale ,  Garth Powis ,  Shuxing Zhang

IPC: A61K31/433 ,  C07C59/90 ,  C07C65/40 ,  C07C233/75 ,  C07C235/64 ,  C07C237/42 ,  C07C271/22 ,  C07C311/21 ,  C07C317/14 ,  C07C317/18 ,  C07C317/28 ,  C07C317/44 ,  C07C323/65 ,  C07D213/50 ,  C07D213/643 ,  C07D213/74 ,  C07D213/76 ,  C07D231/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D231/42 ,  C07D233/20 ,  C07D233/26 ,  C07D233/64 ,  C07D237/08 ,  C07D237/18 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/52 ,  C07D261/08 ,  C07D261/20 ,  C07D263/32 ,  C07D263/42 ,  C07D263/56 ,  C07D271/10 ,  C07D271/113 ,  C07D277/52 ,  C07D277/64 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/135 ,  C07D295/192 ,  C07D295/26 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07F9/6558

CPC classification number: A61K31/433 ,  C07C59/90 ,  C07C65/40 ,  C07C233/75 ,  C07C235/64 ,  C07C237/42 ,  C07C271/22 ,  C07C311/21 ,  C07C317/14 ,  C07C317/18 ,  C07C317/28 ,  C07C317/44 ,  C07C323/65 ,  C07D213/50 ,  C07D213/643 ,  C07D213/74 ,  C07D213/76 ,  C07D231/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D231/42 ,  C07D233/20 ,  C07D233/26 ,  C07D233/64 ,  C07D237/08 ,  C07D237/18 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/52 ,  C07D261/08 ,  C07D261/20 ,  C07D263/32 ,  C07D263/42 ,  C07D263/56 ,  C07D271/10 ,  C07D271/113 ,  C07D277/52 ,  C07D277/64 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/135 ,  C07D295/192 ,  C07D295/26 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07F9/65583

Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

公开(公告)号：US09233973B2

公开(公告)日：2016-01-12

申请号：US14336075

申请日：2014-07-21

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Board of Regents, The University of Texas System ,  The Regents of the University of California, a California Corporation

Inventor： Leonard M. Neckers ,  Marc B. Cox ,  Jane B. Neckers ,  Yeong Sang Kim ,  Aki Iwai ,  Yangmin Ning ,  Johanny Kugelman-Tonos ,  Heather A. Balsiger ,  Robert Fletterick

IPC: C07D491/048 ,  C07C233/66 ,  C07C235/84 ,  A61K31/195 ,  A61K45/06 ,  A61K31/167 ,  A61K31/4741 ,  A61K31/165 ,  A61K31/192 ,  A61K31/40 ,  A61K31/4355

CPC classification number: A61K31/4741 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4355 ,  A61K45/06 ,  C07C233/66 ,  C07C235/84 ,  C07D491/048 ,  A61K2300/00

Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.

Abstract translation: 提供了与雄激素受体激素结合结构域（也称为FKBP52靶向剂（FTA））上预测的FK506结合蛋白52（FKBP52）相互作用表面结合的药物组合物。 发现本发明的这些组合物特异性地识别雄激素受体上的FKBP52调节表面并抑制FKBP52与雄激素受体的功能相互作用。 还提供了包含药物组合物的组合物，以及使用方法，治疗和筛选方法。

公开(公告)号：US20150017201A1

公开(公告)日：2015-01-15

申请号：US14209845

申请日：2014-03-13

Applicant: Regents of the University of Minnesota ,  Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting for and on behalf of Ariz

Inventor： Yung Chang ,  Hao Yan ,  Sidney Hecht ,  Paul Pentel ,  Xiaowei Liu ,  Rumit Maini

IPC: A61K39/385 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K39/0013 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55561 ,  A61K2039/6025 ,  A61K2039/627 ,  A61K2039/645

Abstract: The present invention provides DNA-nanostructures comprising and at least one targeting moiety, wherein the at least one targeting moiety is linked to the DNA-nanostructure; and wherein the at least one targeting moiety is nicotine or a nicotine analogue. These compounds elicit an immunogenic response in individuals and are useful as vaccines for ameliorating nicotine dependence.

Abstract translation: 本发明提供了包含和至少一个靶向部分的DNA-纳米结构，其中至少一个靶向部分连接到DNA-纳米结构; 并且其中所述至少一个靶向部分是尼古丁或尼古丁类似物。 这些化合物在个体中引起免疫原性反应，并且可用作改善尼古丁依赖性的疫苗。

公开(公告)号：US08809546B2

公开(公告)日：2014-08-19

申请号：US13630554

申请日：2012-09-28

Applicant: The Regents of the University of California ,  The Regents of the University of Michigan

Inventor： Omar M. Yaghi ,  Hideki Hayashi ,  Rahul Banerjee ,  Kyo Sung Park ,  Bo Wang ,  Adrien P. Cote

IPC: B01J20/22 ,  B01J31/16 ,  B01J31/18 ,  C07F19/00 ,  C07F15/06 ,  C07F3/06 ,  C07F3/00 ,  C07F15/00

CPC classification number: B01J20/226 ,  B01J20/30 ,  B01J31/1691 ,  B01J31/1815 ,  B01J31/183 ,  B01J2531/0216 ,  B01J2531/26 ,  B01J2531/33 ,  B01J2531/845 ,  C01B39/00 ,  C01B39/02 ,  C07F3/00 ,  C07F3/003 ,  C07F3/06 ,  C07F15/00 ,  C07F15/065 ,  C07F19/005 ,  F17C11/005 ,  Y02C10/08

Abstract: The disclosure provides zeolitic frameworks for gas separation, gas storage, catalysis and sensors. More particularly the disclosure provides zeolitic frameworks (ZIFs). The ZIF of the disclosure comprises any number of transition metals or a homogenous transition metal composition.

Abstract translation: 本公开提供了用于气体分离，气体储存，催化和传感器的沸石骨架。 更具体地，本公开提供沸石骨架（ZIF）。 本公开的ZIF包括任何数量的过渡金属或均匀的过渡金属组成。