公开(公告)号：US20240087084A1

公开(公告)日：2024-03-14

申请号：US18271202

申请日：2022-01-06

Applicant: THE USA, as represented by the Secretary, Department of Health and Human Services ,  THE UNIVERSITY OF CHICAGO

Inventor： Hari SHROFF ,  Yicong WU ,  Xiaofei HAN ,  Patrick LA RIVIERE

IPC: G06T3/40 ,  G06T5/50

CPC classification number: G06T3/4053 ,  G06T3/4046 ,  G06T5/50 ,  G06T2207/10056 ,  G06T2207/20212

Abstract: Various embodiments for systems and methods for producing one-dimensional super-resolved images from diffraction-limited line-confocal images using a trained neral network to generate a one-dimensional super-resolved output as well as an isotropic, in-plane super-resolved image are disclosed, wherein the neural network is trained using a training set comprising a plurality of matched training pairs, each training pair of the plurality of training pairs comprising a diffraction-limited line confocal image of the plurality of diffraction-limited line confocal images of the image type and a one dimensional super resolved image corresponding to the diffraction-limited line confocal image of the plurality of diffraction limited line confocal images.

公开(公告)号：US20240076670A1

公开(公告)日：2024-03-07

申请号：US18481735

申请日：2023-10-05

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Elizabeth McNally

IPC: C12N15/113 ,  A61K47/60

CPC classification number: C12N15/113 ,  A61K47/60 ,  C12N15/1138 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/33

Abstract: Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy.

公开(公告)号：US11921393B2

公开(公告)日：2024-03-05

申请号：US17249646

申请日：2021-03-08

Applicant: The University of Chicago

Inventor： Juan Jose de Pablo ,  Paul Franklin Nealey ,  Xiao Li ,  Jose A. Martinez-Gonzalez ,  Monirosadat Sadati ,  Rui Zhang ,  Ye Zhou

IPC: G02F1/139 ,  C09K19/00 ,  G02F1/1333 ,  G02F1/137

CPC classification number: G02F1/1393 ,  G02F1/137 ,  G02F1/1396 ,  C09K19/00 ,  G02F1/1333 ,  G02F1/13793 ,  G02F2201/00

Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

公开(公告)号：US20240068007A1

公开(公告)日：2024-02-29

申请号：US18236022

申请日：2023-08-21

Applicant: University of Chicago

Inventor： Eric Gerd Pamer ,  Nicholas Dylla ,  Christopher Lehmann

IPC: C12Q1/10 ,  G01N33/92

CPC classification number: C12Q1/10 ,  G01N33/92 ,  G01N2800/50

Abstract: Provided herein are biomarkers associated with risk of bacterial infection, particularly hospital inquired infections, such as following surgeries. In particular, provided herein are fecal biomarkers (e.g., microbiomic, metabolomic, etc.) that correlate with elevated risk of infection in subjects following surgery (e.g., organ transplant surgery), and methods of treating and/or preventing such infections.

公开(公告)号：US20240050571A1

公开(公告)日：2024-02-15

申请号：US18175956

申请日：2023-02-28

Applicant: LOYOLA UNIVERSITY OF CHICAGO

Inventor： Daniel Paul Becker ,  Marlon Ray Lutz, JR.

IPC: A61K41/00 ,  A61K47/54 ,  C07F7/08

CPC classification number: A61K41/0095 ,  A61K47/545 ,  C07F7/0814

Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.

公开(公告)号：US11896935B2

公开(公告)日：2024-02-13

申请号：US15680064

申请日：2017-08-17

Applicant: UCHICAGO ARGONNE, LLC ,  THE UNIVERSITY OF CHICAGO

Inventor： Seth B. Darling ,  Jeffrey W. Elam ,  Ruben Waldman

IPC: B01D69/02 ,  B01D69/12 ,  B01D71/36 ,  B01D71/42 ,  B01D67/00 ,  B01D71/34 ,  B01D69/14 ,  B01D71/82 ,  B01D71/68 ,  B01D69/10

CPC classification number: B01D69/02 ,  B01D67/0002 ,  B01D69/125 ,  B01D71/36 ,  B01D71/42 ,  B01D67/0072 ,  B01D67/0079 ,  B01D69/105 ,  B01D69/141 ,  B01D69/148 ,  B01D71/34 ,  B01D71/68 ,  B01D71/82

Abstract: Polymeric membranes are modified via SIS to promote membrane resilience, prolong membrane lifetime, and mitigate fouling. Modified membranes include an inorganic material within an outer portion of the modified membrane and a polymeric core that remains unmodified by the inorganic material. The polymer may be removed leaving an inorganic material patterned from an initial unmodified polymeric membrane.

公开(公告)号：US11886379B2

公开(公告)日：2024-01-30

申请号：US17641036

申请日：2020-09-09

Applicant: University of Chicago

Inventor： Pranav Gokhale ,  Yongshan Ding ,  Thomas Propson ,  Frederic T. Chong

IPC: G06F9/02 ,  G06F15/82 ,  G06N10/40

CPC classification number: G06F15/82 ,  G06N10/40

Abstract: A computing system includes a quantum processor with qubits, a classical memory including a quantum program defining a plurality of instructions in a source language, and a classical processor configured to: (i) receive a circuit of gates representing a quantum program for a variational algorithm in which computation is interleaved with compilation; (ii) identify a plurality of blocks, each block includes a subcircuit of gates, leaving one or more remainder subcircuits of the circuit of gates outside of the plurality of blocks; (iii) pre-compile each block of the plurality of blocks with a pulse generation program to generate a plurality of pre-compiled blocks including control pulses configured to perform the associated block on the quantum processor; and (iv) iteratively execute the quantum program using the pre-compiled blocks as static during runtime and recompiling the one or more remainder subcircuits on the classical processor at each iteration of execution.

公开(公告)号：US11883417B2

公开(公告)日：2024-01-30

申请号：US17577882

申请日：2022-01-18

Applicant: The University of Chicago

Inventor： Deng Pan ,  Masha Kocherginsky ,  Suzanne D. Conzen

IPC: A61K31/575 ,  A61K45/06 ,  A61K33/243 ,  A61K31/282 ,  A61K31/337 ,  A61K31/357 ,  A61K31/4745 ,  A61K31/7068 ,  A61K39/395 ,  A61N5/00 ,  A61J1/00 ,  A61K31/567 ,  A61K31/58

CPC classification number: A61K31/575 ,  A61J1/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/357 ,  A61K31/4745 ,  A61K31/567 ,  A61K31/58 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/3955 ,  A61K45/06 ,  A61N5/00 ,  A61K31/575 ,  A61K2300/00

Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.

公开(公告)号：US20240026528A1

公开(公告)日：2024-01-25

申请号：US18357114

申请日：2023-07-22

Applicant: UNIVERSITY OF NORTH TEXAS ,  UCHICAGO ARGONNE, LLC ,  THE UNIVERSITY OF CHICAGO

Inventor： Diana BERMAN ,  Elena V. SHEVCHENKO ,  Supratik GUHA

IPC: C23C16/04 ,  C23C16/06 ,  C23C16/01

CPC classification number: C23C16/045 ,  C23C16/06 ,  C23C16/01

Abstract: A method of forming an inorganic film on a surface can include depositing a polymer at a layer on a surface, swelling the polymer with a solvent to produce a swollen polymer on the surface, infiltrating the swollen polymer with a precursor, removing the swollen polymer after infiltrating the swollen polymer with the precursor, and forming a porous inorganic film on the surface based on removing the swollen polymer.

公开(公告)号：US11881391B1

公开(公告)日：2024-01-23

申请号：US17402171

申请日：2021-08-13

Applicant: Radiation Monitoring Devices, Inc. ,  University of Chicago ,  Brookhaven Science Associates, LLC

Inventor： Harish B. Bhandari ,  Vivek V. Nagarkar ,  Olena E. Ovechkina ,  Henry J. Frisch ,  Klaus Attenkofer ,  John M. Smedley

IPC: H01J9/12 ,  H01J1/34 ,  H02S50/15 ,  C23C14/34 ,  C23C14/54 ,  C23C14/00 ,  C23C14/06 ,  C30B23/02 ,  C30B29/40 ,  C23C14/02 ,  C23C14/16 ,  G01N21/63

CPC classification number: H01J9/12 ,  C23C14/0036 ,  C23C14/025 ,  C23C14/06 ,  C23C14/165 ,  C23C14/3414 ,  C23C14/545 ,  C23C14/548 ,  C30B23/02 ,  C30B29/40 ,  G01N21/63 ,  H01J1/34 ,  H02S50/15

Abstract: Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as, for example photocathode having a high quantum efficiency, and simple components fabricated by those methods.