公开(公告)号：US20130116190A1

公开(公告)日：2013-05-09

申请号：US13728855

申请日：2012-12-27

Applicant: ALLERGAN, INC.

Inventor： Jacob Pollock ,  Xiaojie Yu ,  Christopher Traina ,  Nicholas J. Manesis ,  Lauren Kokai ,  Dennis Van Epps ,  Darin Messina

IPC: A61K38/39

CPC classification number: A61K38/39 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06 ,  C08L5/08 ,  A61K31/728 ,  A61K2300/00

Abstract: Hydrogels comprising a macromolecular matrix including a crosslinked combination of hyaluronic acid and collagen, are provided for tissue engineering applications.

Abstract translation: 提供包含包含透明质酸和胶原蛋白的交联组合的大分子基质的水凝胶用于组织工程应用。

公开(公告)号：US20240366841A1

公开(公告)日：2024-11-07

申请号：US18543288

申请日：2023-12-18

Applicant: Allergan, Inc.

Inventor： Jacob F. Pollock ,  Lauren E. Kokai ,  Cunqi Cui ,  Xiaojie Yu ,  Dennis E. Van Epps ,  Darin J. Messina

IPC: A61L27/52 ,  A61K8/04 ,  A61K8/73 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

公开(公告)号：US11833269B2

公开(公告)日：2023-12-05

申请号：US16595481

申请日：2019-10-08

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/52 ,  A61K8/73 ,  A61Q19/08 ,  A61K8/04 ,  A61L27/26 ,  A61L27/36

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61Q19/08 ,  A61K2800/91 ,  A61L2400/06 ,  A61L2430/34 ,  A61L27/26 ,  C08L5/08 ,  A61L27/26 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US11083684B2

公开(公告)日：2021-08-10

申请号：US14928634

申请日：2015-10-30

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  C08B37/08 ,  A61K8/04 ,  A61Q19/08

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

公开(公告)号：US11065428B2

公开(公告)日：2021-07-20

申请号：US15932365

申请日：2018-02-16

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Lance E. Steward ,  Guang Wei Lu ,  Patrick M. Hughes ,  Sheshadri Neervannan

IPC: A61M37/00 ,  A61K38/48 ,  A61K47/36 ,  A61P17/06 ,  A61P29/00 ,  A61K9/00 ,  A61K47/42 ,  B29C33/42

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.

公开(公告)号：US20200237968A1

公开(公告)日：2020-07-30

申请号：US16850981

申请日：2020-04-16

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Xiaojie Yu ,  Athene W. Chan

IPC: A61L27/56 ,  B29C41/14 ,  B29C41/22 ,  A61L28/00 ,  A61L31/14 ,  A61L24/00 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/34 ,  A61L31/04 ,  A61L31/06 ,  A61L31/10

Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

公开(公告)号：US09950092B2

公开(公告)日：2018-04-24

申请号：US15199150

申请日：2016-06-30

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Sumit Paliwal ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61K8/33 ,  A61Q19/08 ,  A61L27/20 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61K8/33 ,  A61K8/73 ,  A61K8/735 ,  A61K2800/262 ,  A61K2800/95 ,  A61L27/54 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08L5/08

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.

公开(公告)号：US20170266344A1

公开(公告)日：2017-09-21

申请号：US15609967

申请日：2017-05-31

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicolas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/36 ,  A61L27/26 ,  C08L89/06 ,  A61Q19/08 ,  A61K8/04 ,  C08L5/08 ,  A61L27/52 ,  A61K8/73

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L5/08 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US20170174858A1

公开(公告)日：2017-06-22

申请号：US15454901

申请日：2017-03-09

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Xiaojie Yu ,  Athene Wan Chie Chan

IPC: C08J9/26 ,  A61L31/14 ,  A61L31/06 ,  B01D39/16 ,  B05D5/00 ,  B05D1/38 ,  B05D3/00 ,  C09D171/02 ,  C09D167/04

CPC classification number: C08J9/26 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L2400/08 ,  B01D39/1692 ,  B01D2239/1208 ,  B01D2239/1216 ,  B05D1/38 ,  B05D3/007 ,  B05D5/00 ,  C08J2201/04 ,  C08J2201/042 ,  C08J2201/0422 ,  C08J2201/0462 ,  C08J2201/0464 ,  C08J2201/05 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2207/12 ,  C08J2325/10 ,  C08J2353/02 ,  C08J2375/04 ,  C08J2383/04 ,  C09D167/04 ,  C09D171/02

Abstract: Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material. The porogens can be used to form a scaffold for making a resulting porous elastomer when the scaffold is removed.

公开(公告)号：US20160279290A1

公开(公告)日：2016-09-29

申请号：US15178306

申请日：2016-06-09

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Jessamine P. Winer-Jones ,  Nicolas J. Manesis ,  Hengli Liu ,  Gabriel Njikang ,  Athene Wan Chie Chan

IPC: A61L27/20 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61K8/676 ,  A61K8/735 ,  A61K31/728 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/204 ,  A61L2300/236 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/00 ,  A61Q19/08

Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.