公开(公告)号：US20190054211A1

公开(公告)日：2019-02-21

申请号：US16107708

申请日：2018-08-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg

IPC: A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L5/04 ,  C08L89/06

Abstract: An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an interpenetrating network of crosslinked second natural polymer macromers having a second elasticity higher than the first elasticity, the IPN structured hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.

公开(公告)号：US20180371416A1

公开(公告)日：2018-12-27

申请号：US16044182

申请日：2018-07-24

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Loran Solorio ,  Phuong Dang

IPC: C12N5/077

Abstract: A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregate. The nanoparticles and/or microparticles act as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate allowing the cell aggregate to be readily manipulated and formed into tissue constructs with defined architectures.

公开(公告)号：US20230098674A1

公开(公告)日：2023-03-30

申请号：US17695215

申请日：2022-03-15

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Worcester Polytechnic Institute

Inventor： Eben Alsberg ,  Anna D. Dikina ,  Marsha W. Rolle ,  Hannah A. Strobel

IPC: A61L27/38 ,  A61K35/42 ,  A61L27/58 ,  A61K35/32 ,  A61K35/44 ,  A61L27/54 ,  A61K35/28 ,  C12N5/071 ,  C12N5/077

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

公开(公告)号：US20220088268A1

公开(公告)日：2022-03-24

申请号：US17544544

申请日：2021-12-07

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61L27/24 ,  C07K14/78 ,  A61L27/54 ,  C12N5/00 ,  A61L27/36 ,  A61K9/50 ,  A61K47/02 ,  A61K47/42

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20210402063A1

公开(公告)日：2021-12-30

申请号：US17474985

申请日：2021-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L89/06 ,  C08L5/04 ,  C08B37/00 ,  C08H1/06 ,  A61L27/26 ,  A61L27/38 ,  C08G65/00 ,  A61L27/20

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US11116875B2

公开(公告)日：2021-09-14

申请号：US16107774

申请日：2018-08-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L24/04 ,  A61L24/00 ,  A61L27/20 ,  A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L89/06 ,  C08L5/04 ,  C08B37/00 ,  C08H1/06 ,  A61L27/26 ,  A61L27/38 ,  C08G65/00

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US10729776B2

公开(公告)日：2020-08-04

申请号：US16155436

申请日：2018-10-09

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  David Wolfson

IPC: A61K47/36 ,  A61K47/42 ,  A61K31/727 ,  C12N5/0775 ,  A61K38/18 ,  A61K35/28 ,  A61K9/00 ,  A61K47/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.

公开(公告)号：US20190298656A1

公开(公告)日：2019-10-03

申请号：US16371806

申请日：2019-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61K9/50 ,  A61K47/02 ,  A61K47/42

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20190060467A1

公开(公告)日：2019-02-28

申请号：US16155436

申请日：2018-10-09

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  David Wolfson

IPC: A61K47/36 ,  A61K35/28 ,  A61K9/00 ,  A61K31/727 ,  A61K47/42 ,  C12N5/0775 ,  A61K38/18 ,  A61K47/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  A61L27/52 ,  C08L5/04 ,  C08L89/06

CPC classification number: A61K47/36 ,  A61K9/00 ,  A61K31/727 ,  A61K35/28 ,  A61K38/1875 ,  A61K47/00 ,  A61K47/42 ,  A61L27/26 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02 ,  C12N5/0662 ,  C12N2533/54 ,  C12N2533/74 ,  C12N2537/00 ,  C12N2537/10 ,  C08L5/04 ,  C08L89/06

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.

公开(公告)号：US10092654B2

公开(公告)日：2018-10-09

申请号：US14795569

申请日：2015-07-09

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Oju Jeon ,  David Wolfson

IPC: A01N63/00 ,  A61K47/36 ,  A61K47/42 ,  A61K31/727 ,  A61K38/18 ,  A61K35/28 ,  A61K9/00 ,  A61K47/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  C12N5/0775

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.