公开(公告)号：US10799613B2

公开(公告)日：2020-10-13

申请号：US14505824

申请日：2014-10-03

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond Weitekamp ,  Robert H. Grubbs ,  Harry A. Atwater ,  James Fakonas

IPC: C09K11/00 ,  A61L27/16 ,  C08G61/08 ,  C08L65/00 ,  A61L27/50 ,  G03F7/029 ,  G03F7/004 ,  C07F15/00 ,  C08F232/08

Abstract: The present invention relates to methods of metathesizing olefins using catalysts previously considered to be practically inactive. The present invention further relates to novel photosensitive compositions, their use as photoresists, and methods related to patterning polymer layers on substrates. Further, modifications to the compositions and method provide for an unprecedented functionalization of the compositions, useful for example in the preparation of sensors, drug delivery systems, and tissue scaffolds. The novel compositions and associated methods also provide for the opportunity to prepare 3-dimensional objects which provide new access to critically dimensioned devices, including for example photonic devices.

公开(公告)号：US10792651B2

公开(公告)日：2020-10-06

申请号：US16341635

申请日：2017-10-17

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. Johns ,  Jessica R. Herron ,  Richard L. Pederson ,  Bryan A. Fiamengo ,  Jennifer A. Beerman ,  Tzu-Pin Lin ,  Crystal K. Chu ,  Robert H. Grubbs

IPC: B01J31/24 ,  B01J31/22 ,  C07F15/00

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

公开(公告)号：US10765777B2

公开(公告)日：2020-09-08

申请号：US16020196

申请日：2018-06-27

Applicant: California Institute of Technology

Inventor： Robert H. Grubbs ,  Christopher B. Marotta

IPC: A61F2/16 ,  A61L27/44 ,  A61L27/52 ,  A61L27/04 ,  A61L27/14 ,  A61L27/26

Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

公开(公告)号：US10646505B2

公开(公告)日：2020-05-12

申请号：US15696474

申请日：2017-09-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Michael D. Schulz ,  Carl M. Blumenfeld ,  Robert H. Grubbs ,  Julia R. Greer ,  Daryl Wei Liang Yee

IPC: A61K31/711 ,  C08F222/10 ,  A61L29/08 ,  A61L31/16 ,  A61L29/16 ,  A61K47/58 ,  A61K47/69 ,  A61K47/54 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  C08F293/00

Abstract: This disclosure is directed to structured compositions, including DNA-functionalized scaffolds, for drug capture, and methods and devices for sequestering chemotherapeutics from physiological fluids using the functionalized scaffolds.

公开(公告)号：US10517992B2

公开(公告)日：2019-12-31

申请号：US14636329

申请日：2015-03-03

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H. Grubbs

IPC: A61L27/16 ,  A61L27/52 ,  A61L27/50

Abstract: The present invention is directed to optical hydrogels, whose shape and/or refractive indices can be catalyzed by the application of light, methods of preparing the same, and optical devices and lenses derived therefrom.

公开(公告)号：US20190282695A1

公开(公告)日：2019-09-19

申请号：US16431605

申请日：2019-06-04

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Robert H. Grubbs ,  Marshall Leedy Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC: A61K41/00 ,  A61B17/22 ,  A61K47/69 ,  A61N7/00 ,  A61K9/00 ,  A61K9/107 ,  A61K31/663 ,  A61K47/24

Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US10188769B2

公开(公告)日：2019-01-29

申请号：US14314994

申请日：2014-06-25

Applicant: University of Southern California ,  California Institute of Technology ,  The Regents of the University of California

Inventor： Mark S. Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David R. Hinton ,  Robert H. Grubbs ,  Dennis O. Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

IPC: A61L27/18 ,  A61K35/30 ,  A61L27/38 ,  A61K35/545 ,  A61K9/00 ,  A61K47/34 ,  A61L27/56

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

公开(公告)号：US09764995B2

公开(公告)日：2017-09-19

申请号：US15375747

申请日：2016-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Kerry Betz ,  David P. Schuman

IPC: C07B47/00 ,  C07F7/08

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.

公开(公告)号：US20170189530A1

公开(公告)日：2017-07-06

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark Thompson ,  Oliver Shafaat ,  Erin Lamb

IPC: A61K41/00 ,  A61F9/007 ,  A61N5/06

CPC classification number: A61K41/0057 ,  A61F9/0079 ,  A61K41/00 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0626 ,  A61N2005/0648

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US09636656B2

公开(公告)日：2017-05-02

申请号：US14362888

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Mark Humayun ,  Clinton J. Regan ,  Azita Emami

IPC: A61K41/00 ,  A61K49/00 ,  B01J19/12 ,  A61K9/00 ,  A61K47/48 ,  A61N5/06 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.