公开(公告)号：US07074491B2

公开(公告)日：2006-07-11

申请号：US10702109

申请日：2003-11-04

Applicant: Xiaodong Liu ,  Andrei V. Bordunov ,  Christopher A. Pohl

Inventor： Xiaodong Liu ,  Andrei V. Bordunov ,  Christopher A. Pohl

IPC: C07F7/10 ,  C07F7/18

CPC classification number: B01J20/3242 ,  B01J20/286 ,  B01J20/287 ,  B01J2220/54 ,  C07F7/1804 ,  Y10T428/31663

Abstract: Polyfunctional silicon compounds of one of the following formula: in which N-PG is a nitrogen containing function group. Also, such compounds bound to substrates for use as chromatography packing.

Abstract translation: 下列化学式的多官能硅化合物：其中N-PG是含氮官能团。 此外，这些化合物与底物结合，用作色谱填充。

公开(公告)号：US06436719B1

公开(公告)日：2002-08-20

申请号：US09520731

申请日：2000-03-08

Applicant: Kannan Srinivasan ,  Christopher A. Pohl

Inventor： Kannan Srinivasan ,  Christopher A. Pohl

IPC: G01N3002

CPC classification number: G01N30/96 ,  G01N30/02 ,  G01N2030/965 ,  B01D15/422

Abstract: A method of chromatographically separating ionic species in an aqueous electrolyte-containing eluent to form an effluent, suppressing the effluent, detecting the suppressed effluent and passing the detected effluent to a regenerant reservoir, thereby displacing the regenerant to flow to the suppressor, wherein the regenerant and effluent are of different chemical compositions.

Abstract translation: 一种在含水电解质的洗脱液中色谱分离离子物质以形成流出物，抑制流出物，检测被抑制的流出物并将检测到的流出物传递到再生剂储存器的方法，从而使再生剂流向抑制器，其中再生剂 流出物的化学成分不同。

公开(公告)号：US5571725A

公开(公告)日：1996-11-05

申请号：US398117

申请日：1995-03-03

Applicant: Christopher A. Pohl ,  Archava Siriraks ,  Rosanne W. Slingsby ,  Harpreet S. Dhillon

Inventor： Christopher A. Pohl ,  Archava Siriraks ,  Rosanne W. Slingsby ,  Harpreet S. Dhillon

IPC: G01N30/02 ,  G01N30/06 ,  G01N30/14 ,  G01N30/96

CPC classification number: G01N30/96 ,  G01N30/14 ,  G01N2030/146 ,  G01N30/02 ,  G01N30/06 ,  Y10T436/173076 ,  Y10T436/19 ,  Y10T436/193333 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Selected polyvalent anions or cations are removed from a liquid sample stream as a pretreatment for the analysis of the liquid sample stream. A stream containing anions of interest, precipitable anions (e.g. sulfate ions) to be removed and an added displacing salt flow through a first cation exchange resin bed having precipitable exchangeable polyvalent ions (e.g. barium ions). Displacing polyvalent cation (e.g. calcium) displaces the exchangeable polyvalent ion from the cation exchange resin into the liquid sample at sufficient concentration to cause the precipitable anion and exchangeable cation to form a precipitate which remains in the resin bed and is thus is removed from the sample stream. Then the anions of interest in the soluble portion of the liquid sample stream are separated and detected. The invention is also applicable to the removal of precipitable cations (e.g. barium ions) by reversing the roles of the anions and cations.

Abstract translation: 选择的多价阴离子或阳离子作为用于分析液体样品流的预处理从液体样品流中去除。 包含感兴趣的阴离子，待除去的可沉淀的阴离子（例如硫酸根离子）的流和通过具有可沉淀的可交换的多价离子（例如钡离子）的第一阳离子交换树脂床的添加的置换盐流。 置换多价阳离子（例如钙）将可交换的多价离子从阳离子交换树脂以足够的浓度置换成液体样品，使得可沉淀的阴离子和可交换的阳离子形成残留在树脂床中的沉淀，因此从样品中除去 流。 然后分离和检测液体样品流的可溶部分中的感兴趣的阴离子。 本发明也适用于通过逆转阴离子和阳离子的作用来除去可沉淀的阳离子（例如钡离子）。

公开(公告)号：US4376047A

公开(公告)日：1983-03-08

申请号：US275109

申请日：1981-06-18

Applicant: Christopher A. Pohl

Inventor： Christopher A. Pohl

IPC: B01D15/36 ,  B01J39/26 ,  B01J41/20 ,  B01J47/00 ,  B03B5/60

CPC classification number: B01D15/361 ,  B01J20/3221 ,  B01J39/26 ,  B01J41/20 ,  B01J47/006 ,  Y10T428/254 ,  Y10T428/26 ,  Y10T428/2982

Abstract: An ion exchange composition formed of insoluble synthetic resin support particles with ion exchange sites at their exposed surfaces, and fine synthetic resin layering particles with ion exchange sites on their exposed surfaces, which attract the ion exchange sites of the support particles so that the layering particles are irreversibly attached as a monolayer to the support particles. The layering particles have a median diameter ranging from 0.002 to 0.09 microns, while the ratio of median diameters of the support particles to layering particles range from 100 to 1, and 5000 to 1. The composition is packed into a column and is used for separation of ions in liquid ion exchange chromatography.

Abstract translation: 由不溶性合成树脂载体颗粒与其暴露表面的离子交换位置形成的离子交换组合物和在其暴露表面上具有离子交换位点的精细合成树脂分层颗粒，其吸引载体颗粒的离子交换位点，使得分层颗粒 作为单层不可逆地附着在载体颗粒上。 分层颗粒的中值直径范围为0.002至0.09微米，而支撑颗粒与分层颗粒的中值直径的比例范围为100至1，5000至1。将组合物装入柱中并用于分离 的离子在液体离子交换色谱中。

公开(公告)号：US09322815B2

公开(公告)日：2016-04-26

申请号：US12036544

申请日：2008-02-25

Applicant: Kannan Srinivasan ,  Rong Lin ,  Sheetal Bhardwaj ,  Christopher A. Pohl

Inventor： Kannan Srinivasan ,  Rong Lin ,  Sheetal Bhardwaj ,  Christopher A. Pohl

IPC: G01N30/96

CPC classification number: G01N30/96

Abstract: Ion chromatography apparatus including (a) a chromatographic column, (b) a source of an aqueous eluent liquid stream, (c) a detector, (d) a recycle line between the detector and the chromatographic column, and (e) a purifying device disposed along the recycle line including ion exchange removal medium. Also, such apparatus with an electrolytic purifying device disposed along the recycle line. Also, methods of using such apparatus.

公开(公告)号：US09144756B2

公开(公告)日：2015-09-29

申请号：US13111882

申请日：2011-05-19

Applicant: Xiaodong Liu ,  Jinhua Chen ,  Christopher A. Pohl

Inventor： Xiaodong Liu ,  Jinhua Chen ,  Christopher A. Pohl

IPC: B01D15/32 ,  B01J20/287 ,  B01J20/32 ,  B01J20/289

CPC classification number: B01D15/327 ,  B01J20/287 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3259 ,  B01J20/3263 ,  B01J20/3265 ,  B01J2220/82

Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.

Abstract translation: 本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。 该组合物与样品的组分提供强烈的芳族和疏水相互作用。 此外，本发明提供新的硅烷的组合物，它们固定在固体基质如二氧化硅上以形成新的固定相。

公开(公告)号：US20120231195A1

公开(公告)日：2012-09-13

申请号：US13416891

申请日：2012-03-09

Applicant: Christopher A. Pohl ,  Kannan Srinivasan ,  Sheetal Bhardwaj

Inventor： Christopher A. Pohl ,  Kannan Srinivasan ,  Sheetal Bhardwaj

IPC: B32B1/08 ,  C08J5/22

CPC classification number: B01J39/26 ,  B01D15/361 ,  B01J41/13 ,  B01J41/20 ,  B01J47/016 ,  Y10T428/1393

Abstract: The present invention provides a new design for high capacity stationary phases for dianion selective ion chromatography. The stationary phases include one or more layers which are products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the condensation polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.

Abstract translation: 本发明提供了用于双阴离子选择性离子色谱法的高容量固定相的新设计。 固定相包括一个或多个作为缩聚产物的层。 多个组分可用于形成第一聚合物层和缩聚物结构，从而提供可被工程化以具有所需性质如离子容量，离子选择性等的固定相。 示例性缩合聚合物通过至少一种多官能化合物与至少一种互补反应性化合物的反应形成，例如与亲电子化合物反应的亲核多官能化合物。

公开(公告)号：US20120028368A1

公开(公告)日：2012-02-02

申请号：US13175699

申请日：2011-07-01

Applicant: Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

Inventor： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

IPC: G01N1/28

CPC classification number: G01N1/34 ,  B01D11/0492 ,  B01J20/043 ,  B01J20/10 ,  B01J20/14 ,  B01J20/26 ,  B01J20/3236 ,  B01J2220/46 ,  B01J2220/66 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/405 ,  G01N30/7206 ,  G01N30/96 ,  G01N2001/4061 ,  Y10T436/10 ,  Y10T436/255

Abstract: A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

Abstract translation: 一种通过在固体吸附剂材料中吸附含水液体样品（包括有机分析物和酸或碱）来预处理和提取液体样品的方法，并且通过与保留在固体吸附剂上的中和离子反应而至少部分地中和酸或碱 在高温和高压下使液体样品吸附的吸附剂材料与有机溶剂接触以将分析物提取到所述溶剂中，优选在具有带有锆金属内表面的萃取室的容器中。

公开(公告)号：US20110192722A1

公开(公告)日：2011-08-11

申请号：US12703668

申请日：2010-02-10

Applicant: Jun Cheng ,  Petr Jandik ,  Christopher A. Pohl

Inventor： Jun Cheng ,  Petr Jandik ,  Christopher A. Pohl

IPC: G01N27/26

CPC classification number: G01N27/30 ,  G01N27/301 ,  G01N27/4166 ,  G01N30/64

Abstract: A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.

Abstract translation: 用于色谱系统的检测电池包括具有入口，出口和对电极的电池体，工作电极，在入口和出口之间延伸并与计数器和工作电极流体接触的样品流动通道，以及 钯/贵金属参考电极系统。 还描述了使用检测单元的方法。

公开(公告)号：US20110174063A1

公开(公告)日：2011-07-21

申请号：US12690862

申请日：2010-01-20

Applicant: Yan LIU ,  Glenn Masami Kuse ,  Victor Barreto ,  Gary L. Gleave ,  Christopher A. Pohl ,  William Dale Case ,  Khosro Moshfegh ,  Michael John McAdams

Inventor： Yan LIU ,  Glenn Masami Kuse ,  Victor Barreto ,  Gary L. Gleave ,  Christopher A. Pohl ,  William Dale Case ,  Khosro Moshfegh ,  Michael John McAdams

IPC: G01N30/02 ,  G01N30/84

CPC classification number: G01N30/96 ,  G01N30/6091 ,  G01N2030/8881 ,  G01N2030/965

Abstract: An ion chromatography housing for easy insertion and removal of a plurality of component cartridges is disclosed. Various components of the IC system are provided in the separate component cartridges. The IC housing includes a capillary separation column and may be connected to conventional-scale components of an IC system. A plurality of IC housings may be provided in a compartment with one or more separation columns. The columns may be capillary columns or conventional-scale columns. A method of using the ion chromatography system is also disclosed. The IC system may be utilized to perform two-dimensional ion chromatographic separation.

Abstract translation: 公开了用于容易地插入和移除多个组件盒的离子色谱盒。 IC系统的各种组件设置在分开的组件盒中。 IC壳体包括毛细管分离柱，并且可以连接到IC系统的常规尺寸部件。 多个IC壳体可以设置在具有一个或多个分离柱的隔间中。 柱可以是毛细管柱或常规尺度的柱。 还公开了使用离子色谱系统的方法。 IC系统可用于进行二维离子色谱分离。