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    Macrolide antiinfective agents
    32.
    发明授权
    Macrolide antiinfective agents 有权
    大环内酯类抗感染药

    公开(公告)号：US06794366B2

    公开(公告)日：2004-09-21

    申请号：US10124988

    申请日：2002-04-17

    Applicant: Daniel Chu ,  Gary Ashley

    Inventor： Daniel Chu ,  Gary Ashley

    IPC: A61K3170

    CPC classification number: C07H17/08 ,  Y02P20/55

    Abstract: Compounds of the formula or the 10,11-anhydro forms therefor, wherein Ra is H or OH; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl; unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C) or substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group or is mono- or disubstituted amino carbonyl; Rf is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (1-10C); substituted or unsubstituted alkynyl (1-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or —ORf may be replaced by —H; one of Z and Y is H and the other is OH or protected OH, or is amino, mono- or dialkyl-amino, protected amino, or an aminoheterocycle or Z and Y together are ═O, ═NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.

    Abstract translation: 式的化合物或其形成的10,11-脱氢，其中R a是H或OH; Rb是H或卤素; R c是H或保护基; Rd是甲基; 未取代的烷基（3-10C）; 取代的烷基（1-10C）; 取代或未取代的烯基（2-10C）或取代或未取代的炔基（2-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20​​℃）; 取代或未取代的芳基烯基（5-20​​℃）; 取代或未取代的芳基炔基（5-20​​℃）; 取代或未取代的酰氨基芳基烷基（5-20​​℃）; 取代或未取代的酰氨基芳基烯基（5-20​​℃）; 或取代或未取代的酰氨基芳基炔基（5-20​​℃）; Re为H或保护基团或为单或二取代氨基羰基; Rf为H; 取代或未取代的烷基（1-10C）; 取代或未取代的烯基（1-10C）; 取代或未取代的炔基（1-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20​​℃）; 或-OR f可以被-H取代; Z和Y之一是H，另一个是OH或保护的OH，或者是氨基，单或二烷基氨基，保护的氨基或氨基杂环，或者Z和Y一起是= O ，= NOH或衍生化的肟，包括其任何药学上可接受的盐和任何立体异构形式及其立体异构形式的混合物，均为抗微生物剂。

    Blunt rolling method and devices
    34.
    发明授权
    Blunt rolling method and devices 有权

    公开(公告)号：US10905152B2

    公开(公告)日：2021-02-02

    申请号：US15940614

    申请日：2018-03-29

    Applicant: Jason Kang ,  Daniel Chu

    Inventor： Jason Kang ,  Daniel Chu

    IPC: A24C3/00 ,  A24C1/04 ,  A24C5/10 ,  A24F9/02 ,  A24C5/46 ,  A24C5/54 ,  A24F25/02 ,  A24C5/34

    Abstract: The embodiments disclose a method including creating a blunt rolling device for rolling blunt smoking products, rolling a wrapper on a wrapper roller tube to create a blunt wrapper tube with a glass tip, tamping smoking material into the blunt wrapper tube at a user defined density, twisting, cutting and tucking wrapper excess into the glass tip, and controlling the operations of the blunt rolling device using a computer, wireless communications and a blunt rolling method and device program for sequencing processes, operating solenoid drive motors and humidity and temperature devices of a smoking material humidor, adjusting settings of devices using predetermined data stored in digital memory devices and accessed using digital processors.

    Self-disabling chip enable input
    36.
    发明授权
    Self-disabling chip enable input 有权
    自我禁用芯片使能输入

    公开(公告)号：US09196316B2

    公开(公告)日：2015-11-24

    申请号：US13995172

    申请日：2011-09-01

    Applicant: Daniel Chu

    Inventor： Daniel Chu

    IPC: G11C5/06 ,  H03K19/00 ,  G11C7/10 ,  G11C7/20

    CPC classification number: G11C5/06 ,  G11C7/109 ,  G11C7/20 ,  H01L24/73 ,  H01L2224/05554 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/48147 ,  H01L2224/48247 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2225/06562 ,  H03K19/00 ,  H01L2924/00012 ,  H01L2224/48145

    Abstract: A multi-die memory package may have separate chip enable inputs for the respective memory dice. Individual chip enable inputs may be separated by other chip connections such as power and ground. The memory dice may include multiple chip enable inputs to allow easy wire bonding of the individual chip enable inputs to a die without requiring any jumpers within the package. Circuitry may be included so that undriven chip enable inputs are masked and driven chip enable inputs may be propagated to the memory die to enable memory accesses while a single chip enable input is only connected to the capacitance of a single bonding pad.

    Abstract translation: 多管芯存储器封装可以具有用于相应存储器管芯的单独的芯片使能输入。 单个芯片使能输入可以由其他芯片连接（如电源和接地）分开。 存储器芯片可以包括多个芯片使能输入，以便容易地将各个芯片使能输入引线连接到芯片，而不需要封装内的任何跳线。 可以包括电路，使得未驱动的芯片使能输入被屏蔽，并且驱动的芯片使能输入可以被传播到存储器管芯，以在单个芯片使能输入仅连接到单个焊盘的电容的同时实现存储器访问。

    NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS
    38.
    发明申请
    NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS 审中-公开
    新型半合成糖苷作为抗菌剂

    公开(公告)号：US20120252741A1

    公开(公告)日：2012-10-04

    申请号：US13440692

    申请日：2012-04-05

    Applicant: Daniel Chu ,  Tao Ye ,  Bing Wang

    Inventor： Daniel Chu ,  Tao Ye ,  Bing Wang

    IPC: A61K38/14 ,  A61P31/04 ,  C07K1/06 ,  C07K9/00

    CPC classification number: C07K9/006

    Abstract: Provided herein are semi-synthetic glycopeptides having antibacterial activity. The semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety with certain acyl groups; conversion of the amide group in amino acid-3 to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring to certain substituted amides. Also provided herein are pharmaceutical compositions comprising the semi-synthetic glycopeptides, and methods of use of the semi-synthetic glycopeptides for the treatment and/or prophylaxis of diseases, especially bacterial infections.

    Abstract translation: 本文提供具有抗菌活性的半合成糖肽。 本文所述的半合成糖肽通过在酸性介质中水解母体糖肽的氨基酸-4的二糖部分而使糖肽进行化学修饰来制备，得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 用某些酰基酰化氨基酸4氨基取代的糖部分上的氨基取代基; 氨基酸-3中的酰胺基转化为各种酰基酰胺，酰基磺酰胺，酰基磺酰脲衍生物; 通过曼尼希反应在氨基酸-7上氨基甲基化与含有磺酰胺或酰基磺酰胺基团的取代基; 并将大环上的酸部分转化为某些取代的酰胺。 本文还提供了包含半合成糖肽的药物组合物，以及使用半合成糖肽来治疗和/或预防疾病，特别是细菌感染的方法。

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