摘要:
There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.
摘要翻译:描述了式I,其中相邻的一对R 5,R 6,R 7和R 8形成链-CZC(G1)=(G2)-Z-,R4,R9和R5的其余部分的式I化合物, R 6,R 7和R 8可以相同或不同,各自表示氢,烷基,卤素,烯基,-NO 2,-NR 1 R 2,-OR 3,-S(O)n R 3; 或被羟基,氨基,烷氧基或羰基氧取代的烷基,n为0,1或2,可以相同或不同的R 1和R 2各自表示氢,烷基,-CONHR 3,苯基或被烷基或卤素取代的苯基 ,或R1和R2与它们所连接的氮原子一起形成5或6元杂环,R 3表示氢,烷基,链烯基或苯基,G1和G2之一是氢,另一个是基团E,每个 E可以相同或不同,为-COOH,5-四唑基或羧酰胺基四唑基,各Z可以相同或不同,为氧或硫,一个或两个原子为 b,c和d为氮原子,其余为碳原子,当a,b,c和d中的两个为氮时,R 9为无意义(具有某些排除)及其药学上可接受的衍生物。 还描述了制备化合物和药物的方法。 抗过敏剂,组合物和含有它们的混合物。
摘要:
Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要:
Camera heads having multiple image sensors, configured to provide digitally articulated images or video, at adjustable resolutions and/or offsets and orientations, to a camera control unit (CCU) or other electronic computing system for display, storage, and/or transmission to other systems are disclosed.
摘要:
A particular method includes storing a manifest file and a parameters file at a data store. The manifest file and the parameters file are associated with a software deployment package. An application associated with the software deployment package is published to a first remote computing device and to a second remote computing device. The method includes receiving first parameter values from the first remote computing device and receiving second parameter values from the second remote computing device. The first parameter values are stored in a first region of the data store that is specific to the first computing device. The second parameter values are stored in a second region of the data store that is specific to the second computing device.
摘要:
A three-dimensional milling method and apparatus is disclosed for milling micrometre and a nanometre scale three-dimensional structures. The apparatus includes an ion column operable to generate a milling beam onto a substrate held on an instrument stage. A patterning computer is operable to control the ion column to generate varying ion beam and/or dwell times or to produce a plurality of milling passes, in which subsequent passes overlap previous passes at least partially to create three-dimensional structures. Optionally, an SEM column may be provided.
摘要:
Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要:
A method enabling a service at a communication network node and a network node adapted to execute the method is provided, wherein a first request, requesting for one or more operations to be associated with a symbol, is received from a first user. The request comprises an instruction, identifying one or more operations. The request triggers the generating of a unique symbol identity, and the creation of a symbol record, associated with the symbol identity, wherein the symbol record, linking the symbol identity to the one or more operations. At the node the symbol identity is also associated with the generated symbol, which is created by a symbol server and forwarded to the first user. Once the symbol has been received by the node in a second request, the symbol identity corresponding to the symbol is retrieved from the symbol server, and the service is enabled by executing the one or more operations according to the symbol record identified by the symbol identity.
摘要:
A chute for inspection and sorting apparatus has first and second flat sections, with the lower end of the first section being disposed over the second section to form a step from which product falls onto the second section. Additional sections may be included. In one variant a third channelled section is included, with the lower end of the second section being disposed over the third section forming a second step from which product falls onto the third section.
摘要:
Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions.