公开(公告)号：US20110245629A1

公开(公告)日：2011-10-06

申请号：US12751508

申请日：2010-03-31

申请人： Jonathon E. Giftakis ,  Timothy J. Denison

发明人： Jonathon E. Giftakis ,  Timothy J. Denison

IPC分类号： A61B5/00

CPC分类号： A61B5/0476 ,  A61B5/1116 ,  A61B5/4094 ,  A61B5/6823 ,  A61B5/6828 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/744 ,  A61B2560/0219 ,  A61B2562/043 ,  G06F19/00

摘要： The temporal correlation between a bioelectrical brain signal of a patient and patient motion data, such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.

摘要翻译： 患者的生物电脑信号与患者运动数据（例如指示患者运动的信号或患者姿势指示器）之间的时间相关性由显示装置显示。 在一些示例中，患者姿势指示器包括患者身体的至少一部分的图形表示。 在一些示例中，显示装置显示生物电脑信号，指示患者运动的信号与指示患者的心脏活动的信号之间的时间相关性。

公开(公告)号：US20110125077A1

公开(公告)日：2011-05-26

申请号：US12951766

申请日：2010-11-22

申请人： Timothy J. Denison ,  Kunal Paralikar ,  Gordon O. Munns ,  Wesley A. Santa ,  Peng Cong ,  Christian S. Nielsen ,  John D. Norton

发明人： Timothy J. Denison ,  Kunal Paralikar ,  Gordon O. Munns ,  Wesley A. Santa ,  Peng Cong ,  Christian S. Nielsen ,  John D. Norton

IPC分类号： A61N5/06 ,  A61N1/36 ,  A61M37/00

CPC分类号： A61N5/0601 ,  A61B2017/00084 ,  A61B2018/00839 ,  A61M5/14276 ,  A61N1/086 ,  A61N1/365 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0612 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0651

摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.

摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。

公开(公告)号：US20100280574A1

公开(公告)日：2010-11-04

申请号：US12694042

申请日：2010-01-26

申请人： David L. Carlson ,  Timothy J. Denison ,  Ali H. Shoeb

发明人： David L. Carlson ,  Timothy J. Denison ,  Ali H. Shoeb

IPC分类号： A61N1/08

CPC分类号： A61N1/36082 ,  G06F2221/2101 ,  G06F2221/2105 ,  G06K9/6268 ,  G06N20/00 ,  G16H50/50

摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.

摘要翻译： 用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。 在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。 此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。 示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

公开(公告)号：US20100114237A1

公开(公告)日：2010-05-06

申请号：US12608815

申请日：2009-10-29

申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  David L. Carlson ,  Paul H. Stypulkowski ,  Scott R. Stanslaski ,  Randy M. Jensen ,  Timothy J. Denison

发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  David L. Carlson ,  Paul H. Stypulkowski ,  Scott R. Stanslaski ,  Randy M. Jensen ,  Timothy J. Denison

IPC分类号： A61N1/00

CPC分类号： A61B5/0476 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0488 ,  A61B5/16 ,  A61B5/165 ,  A61B5/4076 ,  A61B5/4839 ,  A61B5/486 ,  A61M21/00 ,  A61M2021/0072 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36082

摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.

摘要翻译： 可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。 所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。 在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。 此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

公开(公告)号：US20090270844A1

公开(公告)日：2009-10-29

申请号：US12108605

申请日：2008-04-24

申请人： Dale F. Seeley ,  Timothy J. Denison

发明人： Dale F. Seeley ,  Timothy J. Denison

IPC分类号： A61M5/145

CPC分类号： A61M5/14276 ,  A61M5/16804

摘要： An implantable infusion device includes an outlet through which a fluid is deliverable and a reservoir for containing the fluid. A flow path is in fluid communication with the reservoir and the outlet. The flow path includes a pressure regulator and a flow restrictor. The pressure regulator has a housing defining a major chamber and a diaphragm disposed in the housing such that the diaphragm sealingly divides the major chamber into first and second minor chambers. The flow restrictor is in fluid communication with the first and second minor chambers of the pressure regulator and is disposed downstream of the first minor chamber and upstream of the second minor chamber. The device further includes (i) a flow sensor configured to detect information regarding flow rate of the fluid downstream of the flow restrictor, and (ii) a pressure adjustment actuator assembly configured to vary pressure in the first minor chamber of the pressure regulator relative to pressure in the second minor chamber. The device also includes a processor operably coupled to the flow sensor and the pressure adjustment actuator assembly. The processor is configured to provide instructions to the actuator assembly for adjusting the pressure in the first minor chamber relative to pressure in the second minor chamber based on the information from the sensor to regulate flow rate of the fluid.

摘要翻译： 植入式输注装置包括可输送流体的出口和用于容纳流体的储存器。 流动路径与储存器和出口流体连通。 流动路径包括压力调节器和限流器。 压力调节器具有限定主室的壳体和设置在壳体中的隔膜，使得隔膜将主室密封地分成第一和第二小室。 限流器与压力调节器的第一和第二小室流体连通并且设置在第一小室的下游和第二小室的上游。 该装置还包括（i）流量传感器，其被配置为检测关于限流器下游的流体的流速的信息，以及（ii）压力调节致动器组件，其被配置为改变压力调节器的第一小室相对于 第二个小室的压力。 该装置还包括可操作地耦合到流量传感器和压力调节致动器组件的处理器。 处理器被配置为向致动器组件提供指令，用于基于来自传感器的信息来调节流体的流速，相对于第二小室中的压力来调节第一小室中的压力。

公开(公告)号：US20090234302A1

公开(公告)日：2009-09-17

申请号：US12047779

申请日：2008-03-13

申请人： Jason J. Hoendervoogt ,  Timothy J. Denison ,  Todd A. Kallmyer ,  Scott L. Kalpin ,  Scott A. Sarkinen

发明人： Jason J. Hoendervoogt ,  Timothy J. Denison ,  Todd A. Kallmyer ,  Scott L. Kalpin ,  Scott A. Sarkinen

IPC分类号： A61M31/00

CPC分类号： A61M5/14276 ,  A61M5/427 ,  A61M2205/18 ,  A61M2205/215 ,  A61M2205/3317 ,  A61M2205/3515 ,  A61M2205/3523 ,  A61M2209/045

摘要： Systems and methods for orienting a medical instrument relative to at least a portion of a medical device include a first tilt detector associated with the medical instrument and a second tilt detector associated with the medical device. The first tilt detector may be within an orientation device that is coupled to or separate from the medical instrument. The tilt detectors generate signals that may be used to determine the relative orientation between at least a portion of the medical device and medical instrument. For example, in some embodiments, the signals may be used to determine whether the orientations of the portion of the medical device and the medical instrument substantially match.

摘要翻译： 用于使医疗器械相对于医疗装置的至少一部分定向的系统和方法包括与医疗器械相关联的第一倾斜检测器和与医疗装置相关联的第二倾斜检测器。 第一倾斜检测器可以在与医疗器械联接或分离的定向装置内。 倾斜检测器产生可用于确定医疗装置的至少一部分与医疗器械之间的相对取向的信号。 例如，在一些实施例中，信号可以用于确定医疗设备和医疗器械的部分的取向是否基本匹配。

公开(公告)号：US20090082829A1

公开(公告)日：2009-03-26

申请号：US11974931

申请日：2007-10-16

申请人： Eric J. Panken ,  Timothy J. Denison ,  Gregory F. Molnar

发明人： Eric J. Panken ,  Timothy J. Denison ,  Gregory F. Molnar

IPC分类号： A61N1/00

CPC分类号： A61N1/36139 ,  A61B5/048 ,  A61B5/4082 ,  A61B5/7475 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/0693 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/3605 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/37252 ,  G06F3/015

摘要： A patient controls the delivery of therapy through volitional inputs that are detected by a biosignal within the brain. The volitional patient input may be directed towards performing a specific physical or mental activity, such as moving a muscle or performing a mathematical calculation. In one embodiment, a biosignal detection module monitors an electroencephalogram (EEG) signal from within the brain of the patient and determines whether the EEG signal includes the biosignal. In one embodiment, the biosignal detection module analyzes one or more frequency components of the EEG signal. In this manner, the patient may adjust therapy delivery by providing a volitional input that is detected by brain signals, wherein the volitional input may not require the interaction with another device, thereby eliminating the need for an external programmer to adjust therapy delivery. Example therapies include electrical stimulation, drug delivery, and delivery of sensory cues.

摘要翻译： 患者通过由大脑内的生物信号检测到的输入量来控制治疗的传递。 患者的输入可以指向执行特定的身体或精神活动，例如移动肌肉或执行数学计算。 在一个实施例中，生物信号检测模块监测来自患者脑内的脑电图（EEG）信号，并确定EEG信号是否包括生物信号。 在一个实施例中，生物信号检测模块分析EEG信号的一个或多个频率分量。 以这种方式，患者可以通过提供由脑信号检测到的输入量来调节治疗递送，其中，该输入可能不需要与另一个装置的相互作用，从而消除了外部程序员调整治疗递送的需要。 示例治疗包括电刺激，药物递送和感觉线索的递送。

公开(公告)号：US20080269841A1

公开(公告)日：2008-10-30

申请号：US11799108

申请日：2007-04-30

申请人： John J. Grevious ,  Timothy J. Denison

发明人： John J. Grevious ,  Timothy J. Denison

IPC分类号： A61N1/02

CPC分类号： G08C17/02 ,  A61B5/0002 ,  A61M5/172 ,  A61N1/08 ,  A61N1/37223 ,  A61N1/37252 ,  H03F3/393

摘要： This disclosure describes a chopper mixer telemetry circuit for use in a wireless receiver. The receiver may be located in an implantable medical device (IMD) or external programmer. The chopper mixer telemetry circuit may include a mixer amplifier that operates as a synchronous demodulator to provide selective extraction of wireless signals received from a transmitter while suppressing out-of-band noise that can undermine the reliability of the telemetry link between an IMD or programmer and another device. The mixer amplifier may utilize parallel signal paths to convert the received telemetry signal into an in-phase (I) signal component and a quadrature (Q) signal component and recombine the I and Q signal components to reconstruct the total signal independently of the phase mismatch between the transmitter and receiver. Each signal path may include a chopper-stabilized mixer amplifier that amplifies telemetry signals within a desired band while suppressing out-of-band noise.

摘要翻译： 本公开描述了一种用于无线接收机的斩波器混频器遥测电路。 接收器可以位于可植入医疗装置（IMD）或外部编程器中。 斩波混频器遥测电路可以包括混频器放大器，其作为同步解调器操作以提供从发射机接收的无线信号的选择性提取，同时抑制可能破坏IMD或编程器之间的遥测链路的可靠性的带外噪声， 另一个设备。 混频器放大器可以利用并行信号路径将接收到的遥测信号转换为同相（I）信号分量和正交（Q）信号分量，并重新组合I和Q信号分量，以独立于相位失配重建总信号 在发射机和接收机之间。 每个信号路径可以包括斩波稳定的混频器放大器，其在抑制带外噪声的同时放大期望频带内的遥测信号。

公开(公告)号：US20080269630A1

公开(公告)日：2008-10-30

申请号：US11799031

申请日：2007-04-30

申请人： Timothy J. Denison ,  Wesley A. Santa

发明人： Timothy J. Denison ,  Wesley A. Santa

IPC分类号： A61B5/04

CPC分类号： A61B5/053 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/7228 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36082 ,  G06F19/00

摘要： Seizure prediction systems and methods include measuring impedance and a potential within a brain of a patient to determine whether the brain is in a state indicative of a possibility of seizure. In some embodiments, at least one of the measured impedance or the measured potential may be used as a primary indication of the brain state indicative of a possibility of seizure. In one embodiment, if one of the measured impedance or the measured potential indicates a seizure, the other measurement (impedance or potential) may be used to validate whether the brain is in the state indicative of the possibility of seizure.

摘要翻译： 缉获预测系统和方法包括测量患者的脑中的阻抗和潜力，以确定大脑是否处于指示癫痫发作可能性的状态。 在一些实施例中，测量的阻抗或测量电位中的至少一个可以用作指示发作可能性的脑状态的主要指示。 在一个实施例中，如果所测量的阻抗或测量的电位之一表示发作，则可以使用另一测量（阻抗或电位）来验证大脑是否处于表示发作可能性的状态。

公开(公告)号：US07385443B1

公开(公告)日：2008-06-10

申请号：US11700404

申请日：2007-01-31

申请人： Timothy J. Denison

发明人： Timothy J. Denison

IPC分类号： H03F1/02

CPC分类号： H03F3/38 ,  A61B5/04 ,  A61B5/053 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7225 ,  A61B5/7228 ,  A61B5/7242

摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.

摘要翻译： 本公开描述了一种斩波稳定仪表放大器。 放大器被配置为以低功耗实现稳定的低频测量。 仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。 通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。 放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。 该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。