公开(公告)号：US20070064516A1

公开(公告)日：2007-03-22

申请号：US11539945

申请日：2006-10-10

Applicant: Barry Briggs ,  Dominique Freeman ,  Don Alden ,  Jon Leonard ,  Dirk Boecker

Inventor： Barry Briggs ,  Dominique Freeman ,  Don Alden ,  Jon Leonard ,  Dirk Boecker

IPC: G11C8/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150832 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/150954 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/32093 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a sensor configured to detect lancet position along said path during the lancing cycle.

公开(公告)号：US20060204399A1

公开(公告)日：2006-09-14

申请号：US10541124

申请日：2003-12-30

Applicant: Dominique Freeman ,  Dirk Boecker ,  Robert Jones ,  David Cullen ,  Malcolm McLeod ,  William Carlsen ,  Michael Owen ,  Christopher Dryer

Inventor： Dominique Freeman ,  Dirk Boecker ,  Robert Jones ,  David Cullen ,  Malcolm McLeod ,  William Carlsen ,  Michael Owen ,  Christopher Dryer

IPC: G01N21/64 ,  C12M1/34

CPC classification number: A61B5/14532 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/157 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/6408

Abstract: A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to fit within the metering device. The analyte detecting members may be optical system using fluorescence lifetime to determine analyte levels. In one embodiment, the device may also include a fluid spreader positioned over at least a portion of the analyte detecting member to urge fluid toward one of the detecting members. A plurality of analyte detecting members may be used. Each analyte detecting member may be a low volume device.

公开(公告)号：US07025774B2

公开(公告)日：2006-04-11

申请号：US10127395

申请日：2002-04-19

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC: A61B17/14

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoids may drive the lancet using electromagnetic force. Advancement and retraction of a lancet may be controlled by a feedback loop monitoring the position and velocity of the lancet embodiments of the lancet driver can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet and method for using a lancet to maintain the patency of the wound tract once the lancet has cut into the skin.

公开(公告)号：US5710630A

公开(公告)日：1998-01-20

申请号：US530241

申请日：1995-10-10

Applicant: Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

Inventor： Matthias Essenpreis ,  Alexander Knuettel ,  Dirk Boecker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/45 ,  G01N21/49 ,  G01N33/487 ,  G01B9/02

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/45 ,  G01N21/49

Abstract: A method for the analytical determination of the glucose concentration in a biological sample. In a detection step, light is irradiated into the sample and the light emerging therefrom after interaction with the sample emerges therefrom is detected in order to measure a physical light property affected by said interaction. The glucose concentration is determined from this measurement in an evaluation step. To provide a method for determining glucose in reagent-free and non-invasive manner, the invention proposes that a portion of the light emitted by the light source be guided along a reference light path of defined optical path length to the photodetector, that the total measuring light path also has a defined optical length and that the measuring light path after it has traversed the sample is so combined with the reference light path that the measuring light and the reference light interfere with each other. The photodetector measures an interference signal used in the evaluation step to determine the glucose concentration.

Abstract translation: PCT No.PCT / DE95 / 00573 Sec。 371 1995年10月10日第 102（e）1995年10月10日日期PCT提交1995年4月26日PCT公布。 WO95 / 30368 PCT出版物 日期：1995年11月16日一种用于分析生物样品中葡萄糖浓度的方法。 在检测步骤中，将光照射到样品中，并且检测出与样品相互作用后从其出来的光从其中出来的光，以测量受所述相互作用影响的物理光特性。 在评价步骤中由该测定确定葡萄糖浓度。 为了提供一种以无试剂和非侵入性方式测定葡萄糖的方法，本发明提出将由光源发射的光的一部分沿着限定的光路长度的参考光路引导到光电检测器，总共 测量光路还具有限定的光学长度，并且其经过样本之后的测量光路与参考光路组合，使得测量光和参考光彼此干涉。 光电检测器测量在评估步骤中使用的干扰信号以确定葡萄糖浓度。

公开(公告)号：US5676143A

公开(公告)日：1997-10-14

申请号：US677923

申请日：1996-07-10

Applicant: Jan Henning Simonsen ,  Dirk Boecker

Inventor： Jan Henning Simonsen ,  Dirk Boecker

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  G01N21/59 ,  G01N33/483

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/6826 ,  A61B5/6833 ,  A61B5/6838 ,  A61B2562/0233 ,  A61B2562/046

Abstract: An apparatus for determination of a glucose concentration in a biological matrix includes an irradiation device for irradiating light as primary light into a biological matrix, and a detection device for measuring intensity of light emerging as secondary light through the boundary surface of the biological matrix. The detection device detects light from the irradiation device after the light has propagated along a light path in the biological matrix. A data processing device processes measurement signals from the detection device. The irradiation device provides spatially limited illumination of an irradiation site, and the detection device is configured for spatially limited measurements of the secondary light emerging at the detection site. The detection site is located relative to the irradiation site such that the secondary light is multiply scattered at scattering centers in the biological matrix. The irradiation and detection devices are configured to provide at least two different light paths within the biological matrix during detection measurements, and to perform at least two detection measurements wherein the light paths are different. The detection device generates separate measurement signals for each of the at least two detection measurements. The data processing device converts the separate measurement signals into a signal which corresponds to a glucose concentration in the biological matrix.

Abstract translation: 用于测定生物体中葡萄糖浓度的装置包括将光作为一次光照射到生物体中的照射装置，以及检测装置，用于测量通过生物体的边界面产生的二次光的强度。 检测装置在光沿生物基质中的光路传播之后，检测来自照射装置的光。 一种数据处理装置从所述检测装置处理的测量信号。 照射装置提供照射部位的空间有限的照明，并且检测装置被配置用于在检测部位出现的二次光的空间有限的测量。 检测位置相对于照射部位定位，使得二次光在生物基质中的散射中心多次散射。 照射和检测装置被配置为在检测测量期间在生物矩阵内提供至少两个不同的光路，并且执行其中光路不同的至少两个检测测量。 的检测装置产生用于所述至少两个检测测量的单独的测量信号。 所述数据处理装置中的单独的测量信号转换成对应于在生物基质中的葡萄糖浓度的信号。

公开(公告)号：US08905945B2

公开(公告)日：2014-12-09

申请号：US13433402

申请日：2012-03-29

Applicant: Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique M. Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B17/14 ,  A61B17/32 ,  A61B5/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/155

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  G01N27/28 ,  G06F19/00 ,  G06Q50/24

Abstract: A body fluid sampling system for use on a tissue site includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator.

Abstract translation: 用于组织部位的体液取样系统包括单个驱动力发生器。 多个穿透构件可操作地联接到力发生器。 力产生器沿着路径将每个构件沿穿过壳体的穿透构件出口移动到组织部位中，停止在组织部位中，并从组织部位中退出。 柔性支撑构件将穿透构件联接以限定线性阵列。 支撑构件是可移动的并且构造成将每个穿透构件移动到与力发生器相关联的发射位置。

公开(公告)号：US08622930B2

公开(公告)日：2014-01-07

申请号：US13184644

申请日：2011-07-18

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC: A61B5/00

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.

公开(公告)号：US08574168B2

公开(公告)日：2013-11-05

申请号：US11691306

申请日：2007-03-26

Applicant: Dominique Freeman ,  Dirk Boecker

Inventor： Dominique Freeman ,  Dirk Boecker

IPC: A61B5/00 ,  A61B17/14 ,  A61B17/32

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radially outward from the cartridge to penetrate tissue. A plurality of analyte sensors are coupled to the single cartridge and are positioned on the cartridge to receive body fluid from a wound in the tissue created by the penetrating member.

公开(公告)号：US08430828B2

公开(公告)日：2013-04-30

申请号：US11627547

申请日：2007-01-26

Applicant: Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Mike Cane ,  Matt Schumann ,  Mike Beadmann

Inventor： Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Mike Cane ,  Matt Schumann ,  Mike Beadmann

IPC: A61B5/00

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend outward from the cartridge to penetrate tissue. Each cavity has a longitudinal opening that provides access to an elongate portion of the penetrating member. A sterility barrier is coupled to the cartridge. The sterility barrier covers a plurality of the longitudinal openings. The sterility barrier is configured to be moved so that the elongate portion is accessed by the gripper without touching the barrier.

Abstract translation: 提供了一种与夹具一起使用的装置。 提供限定多个空腔的盒。 多个穿透构件至少部分地容纳在盒的空腔中。 穿透构件可滑动地移动以从筒向外延伸以穿透组织。 每个空腔具有纵向开口，其提供对穿透构件的细长部分的通路。 无菌屏障耦合到墨盒。 无菌屏障覆盖多个纵向开口。 无菌屏障被配置为移动，使得细长部分被夹持器接近而不接触屏障。

公开(公告)号：US20120238907A1

公开(公告)日：2012-09-20

申请号：US13484412

申请日：2012-05-31

Applicant: Dirk Boecker ,  Dominique M. Freeman ,  Don Alden ,  Matt Schumann ,  Mike Beadman

Inventor： Dirk Boecker ,  Dominique M. Freeman ,  Don Alden ,  Matt Schumann ,  Mike Beadman

IPC: A61B5/151

CPC classification number: A61B5/150709 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150183 ,  A61B5/150198 ,  A61B5/150267 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150511 ,  A61B5/150572 ,  A61B5/15061 ,  A61B5/150702 ,  A61B5/150732 ,  A61B5/150885 ,  A61B5/150946 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/1518 ,  A61B5/157

Abstract: In one aspect, a body fluid sampling device is provided using a penetrating member to extract fluid from an anatomical feature. The device comprises a penetrating member actuator for moving the penetrating member inbound towards the anatomical feature and a non-spring based, penetrating member retractor for moving the penetrating member outbound away from the anatomical feature. The penetrating member actuator may be adapted to move the penetrating member at a velocity greater than a velocity achieved by the penetrating member retractor.

Abstract translation: 在一个方面，使用穿透构件提供体液取样装置，以从解剖特征提取流体。 该装置包括穿透构件致动器，用于使穿透构件朝向解剖特征入口移动，以及非弹性穿透构件牵缩器，用于将穿透构件移出远离解剖特征。 穿透构件致动器可以适于以大于由穿透构件牵开器实现的速度的速度移动穿透构件。