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公开(公告)号：US20200368696A1
公开(公告)日：2020-11-26
申请号：US16918431
申请日：2020-07-01
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , Mikhail Kozlov
Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
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公开(公告)号：US10252199B2
公开(公告)日：2019-04-09
申请号：US15448248
申请日：2017-03-02
Applicant: EMD Millipore Corporation
Inventor： Onur Y. Kas , Mikhail Kozlov , Wilson Moya , Sherry A. Leon , Philip Goddard , Jibin Hao , Gabriel Tkacik
IPC: B01D39/16 , B01D39/18 , B01D39/14 , A61L2/02 , C12N7/00 , D01D1/02 , D01D5/00 , D01F6/96 , B01D69/02 , B01D69/10 , B01D39/04 , B01D39/00 , B01D67/00 , B01D61/14
Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US10195550B2
公开(公告)日：2019-02-05
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20170360971A1
公开(公告)日：2017-12-21
申请号：US15691369
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US20170173511A1
公开(公告)日：2017-06-22
申请号：US15448248
申请日：2017-03-02
Applicant: EMD Millipore Corporation
Inventor： Onur Y. Kas , Mikhail Kozlov , Wilson Moya , Sherry A. Leon , Philip Goddard , Jibin Hao , Gabriel Tkacik
CPC classification number: B01D39/1607 , A61L2/022 , B01D39/00 , B01D39/04 , B01D39/14 , B01D39/16 , B01D39/1615 , B01D39/1623 , B01D39/18 , B01D61/14 , B01D67/0004 , B01D67/002 , B01D69/02 , B01D69/10 , B01D2239/0208 , B01D2239/0216 , B01D2239/025 , B01D2239/0442 , B01D2239/0631 , B01D2239/10 , B01D2239/1233 , B01D2323/39 , B01D2323/42 , B01D2325/20 , C12N7/00 , C12N2740/16051 , D01D1/02 , D01D5/0092 , D01F6/96 , D10B2505/04
Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
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Patent Agency Ranking
36.发明申请Methods of Reducing Level of One or More Impurities in a Sample During Protein Purification 审中-公开降低蛋白质纯化过程中样品中一种或多种杂质水平的方法公开(公告)号：US20160016992A1
公开(公告)日：2016-01-21
申请号：US14747029
申请日：2015-06-23
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。
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公开(公告)号：US11278827B2
公开(公告)日：2022-03-22
申请号：US16427942
申请日：2019-05-31
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US11033839B2
公开(公告)日：2021-06-15
申请号：US16208018
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US10722602B2
公开(公告)日：2020-07-28
申请号：US16053523
申请日：2018-08-02
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：USD853831S1
公开(公告)日：2019-07-16
申请号：US29641166
申请日：2018-03-20
Applicant: EMD Millipore Corporation
Designer： Joseph Geringer , Stephen G. Hunt , Mikhail Kozlov , Joseph Almasian , Gregory Straeffer
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