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40 条记录 (耗时 0.038 秒)

    Cell lines and viral isolates associated with multiple sclerosis
    33.
    发明授权
    Cell lines and viral isolates associated with multiple sclerosis 有权
    与多发性硬化相关的细胞系和病毒分离物

    公开(公告)号：US06342383B1

    公开(公告)日：2002-01-29

    申请号：US09133411

    申请日：1998-08-13

    申请人： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    发明人： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    IPC分类号： C12N112

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  Y10S435/912

    摘要： Composition comprising two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of said virus, and a second agent, or a variant of said second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8 1993 under Accession Number V93010816, and from their variant strains.

    摘要翻译： 包含与多发性硬化相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族相关的人病毒或所述病毒的变体组成的第一药剂和第二药剂， 或所述第二药剂的变体，这两种源自相同病毒株的两种致病和/或感染剂分别选自1992年7月22日以保藏号V92072202和EC7PG保藏的ECACC分别保藏的POL-2的菌株 1993年1月8日的ECACC，保藏号V93010816，以及他们的变异株。

    Therapeutic use of specific ligand in MSRV associated diseases
    35.
    发明授权
    Therapeutic use of specific ligand in MSRV associated diseases 有权
    特异性配体在MSRV相关疾病中的治疗用途

    公开(公告)号：US08715656B2

    公开(公告)日：2014-05-06

    申请号：US12997486

    申请日：2009-07-08

    申请人： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

    发明人： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

    IPC分类号： A61K39/395

    CPC分类号： C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No. 1), from 0 to 2 in CDR2(SEQ ID No. 2), from 0 to 2 in CDR3(SEQ ID No. 3), from 0 to 1 in CDR4(SEQ ID No. 4), from 0 to 4 in CDR5(SEQ ID No. 5), from 0 to 2 in CDR6(SEQ ID No. 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

    摘要翻译： 本发明涉及包含SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4，SEQ ID No.5所示的每个互补决定区（CDR）和 SEQ ID No.6或在所述序列中具有任意数目的取代氨基酸的序列，如下所示，CDR1（SEQ ID No.1）中为0至3，CDR2（SEQ ID No.2）为0至2， 在CDR3（SEQ ID No.3）中为0至2，CDR4（SEQ ID No.4）为0至1，CDR5（SEQ ID No.5）为0至4，CDR6（SEQ ID NO：0）为0至2 SEQ ID NO：6），或在所述序列SEQ ID No.1至SEQ ID No.6内具有等同化学功能和性质的其它氨基酸取代的氨基酸。

    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus
    38.
    发明授权
    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus 失效
    用于产生由多发性硬化症相关病毒感染的细胞的过程和培养基

    公开(公告)号：US06071736A

    公开(公告)日：2000-06-06

    申请号：US754010

    申请日：1996-11-20

    申请人： Herve Perron ,  Jean-Marie Seigneurin

    发明人： Herve Perron ,  Jean-Marie Seigneurin

    IPC分类号： A61K39/21 ,  C07K14/035 ,  C07K16/10 ,  C12N5/08 ,  C12N7/00 ,  C12N15/38 ,  C12N15/85 ,  C12P21/08 ,  G01N33/569 ,  A01N63/00 ,  C12N5/00 ,  A61K37/12

    CPC分类号： G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N15/85 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

    摘要： In a process for the in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis (MS), a body sample is taken from an individual suffering from MS. The sample is cultivated in a culture medium that promotes the growth of infected cells to obtain a culture of primary infected cells. A sample of the culture of primary cells or a subculture of the latter is cultivated in series, by successive passages in the culture medium to obtain the culture or cell line infected by a virus associated with MS. The culture medium also contains a beta-interferon antibody or an antibody that is directed against an antigenically close molecule, the antibody playing an inhibiting role in viral expression and allowing long-lasting expression and propagation of the viral strain in the culture or cell line.

    摘要翻译： 在由多发性硬化症（MS）相关的病毒株感染的培养物或细胞系的体外生产过程中，从患有MS的个体取出身体样品。 将样品在促进感染细胞生长的培养基中培养以获得原代感染细胞的培养物。 通过在培养基中连续传代，将原代细胞培养物或后代培养物的样品串联培养，以获得由与MS相关的病毒感染的培养物或细胞系。 培养基还含有针对抗原性紧密的分子的β-干扰素抗体或抗体，所述抗体在病毒表达中起抑制作用，并允许病毒株在培养物或细胞系中的长期表达和繁殖。