公开(公告)号：US12040069B2

公开(公告)日：2024-07-16

申请号：US17218744

申请日：2021-03-31

Applicant: International Business Machines Corporation

Inventor： Qinghuang Lin ,  Pritish Ranjan Parida ,  Mohamed Ghalwash ,  Daby Mousse Sow

IPC: G16H20/30 ,  A61N1/02 ,  A61N1/36 ,  G16H40/40 ,  G16H50/50 ,  G16H50/70 ,  A61N1/05

CPC classification number: G16H20/30 ,  A61N1/025 ,  A61N1/36192 ,  G16H40/40 ,  G16H50/50 ,  G16H50/70 ,  A61N1/0551

Abstract: Techniques regarding neuromodulation are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can include a mapping component that can generate a stimulus map by mapping a stimulus parameter to a response from an entity to application of a neuromodulating stimulus, with the first neuromodulating stimulus being applied to the entity based on the first stimulus parameter, to therapeutically cause or prevent a sensation.

公开(公告)号：US20230366874A1

公开(公告)日：2023-11-16

申请号：US18357266

申请日：2023-07-24

Applicant: International Business Machines Corporation

Inventor： Harikilia Deligianni ,  Bruce B. Doris ,  Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin

IPC: G01N33/487 ,  B01L3/00 ,  C12Q1/00

CPC classification number: G01N33/48735 ,  B01L3/502715 ,  G01N33/48785 ,  G01N33/48792 ,  C12Q1/001 ,  B01L2300/023 ,  B01L2300/123 ,  B01L2300/0645

Abstract: In an approach, using a biomedical device, a processor stimulates a cell sample. A processor senses, based on feedback from at least two chemical sensors of the biomedical device, the presence of at least two types of biomolecules released by the cell sample. A processor records, using a computer chip of the device, data collected by the at least two chemical sensors. A processor sends, using an antenna of the biomedical device, the recorded data to a remote server.

公开(公告)号：US11311233B2

公开(公告)日：2022-04-26

申请号：US15602343

申请日：2017-05-23

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Hariklia Deligianni ,  Bruce B. Doris ,  Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin ,  Roy R. Yu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/06 ,  H01L23/58

Abstract: A sensing and treatment device includes an array of metal nanorod electrodes formed on a substrate, the array including first electrodes for sensing, and second electrodes for electrical pulsation. A data processing system is configured to monitor a parameter using the first electrodes and to activate the electrical pulsation in the second electrodes in accordance with a reading of the parameter.

公开(公告)号：US10756138B2

公开(公告)日：2020-08-25

申请号：US16671990

申请日：2019-11-01

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin

IPC: H01L27/22 ,  H01L43/02 ,  H01L43/08 ,  H01L21/768 ,  G11C11/16 ,  H01L43/12

Abstract: A method of forming a device that includes encapsulating a magnetic resistive access memory (MRAM) stack with a first patternable low-k dielectric material that is patterned by an exposure to produce a via pattern that extends to circuitry to logic devices. The via pattern is developed forming a via opening. The method further includes forming a second patternable low-k dielectric material over first patternable low-k dielectric material and filling the via opening. The second patternable low-k dielectric material is patterned by a light exposure to produce a first line pattern to the MRAM stack and a second line pattern to the via opening. The first line pattern and the second line pattern are developed to form trench openings. Thereafter, electrically conductive material is formed in the trench openings and the via opening.

公开(公告)号：US10684246B2

公开(公告)日：2020-06-16

申请号：US15802802

申请日：2017-11-03

Applicant: International Business Machines Corporation

Inventor： Hariklia Deligianni ,  Bruce B. Doris ,  Damon B. Farmer ,  Steven J. Holmes ,  Qinghuang Lin ,  Nathan P. Marchack ,  Deborah A. Neumayer ,  Roy R. Yu

IPC: G01N27/327 ,  G01N27/48 ,  G01N33/94 ,  H01L21/768 ,  H01L23/48 ,  H01L23/528 ,  G01N33/543 ,  H01L27/15 ,  G01N33/487

Abstract: Embodiments of the invention are directed to a biosensing integrated circuit (IC). A non-limiting example of the biosensing IC includes a plurality of semiconductor substrate layers. A sensor element is formed over a first one of the plurality of semiconductor substrate layers, wherein the sensor element is configured to, based at least in part on the sensor element interacting with a predetermined material, generate data representing a measurable electrical parameter. An adhesion enhancement region is configured to physically couple the sensor element to the first one of the plurality of semiconductor substrate layers. In some embodiments of the invention, the biosensing IC further includes an electrically conductive interconnect network configured to communicatively couple the data representing the measurable electrical parameter to computer elements.

公开(公告)号：US20200094300A1

公开(公告)日：2020-03-26

申请号：US16695321

申请日：2019-11-26

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin ,  Nathan P. Marchack ,  Roy R. Yu

IPC: B08B17/02 ,  B08B17/06 ,  A61B5/00 ,  A61B5/04

Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.

公开(公告)号：US20190165400A1

公开(公告)日：2019-05-30

申请号：US15826409

申请日：2017-11-29

Applicant: International Business Machines Corporation

Inventor： Lele Peng ,  Qinghuang Lin ,  Yujun Xie

IPC: H01M8/1016 ,  H01M6/18

Abstract: A solid-state rechargeable 3D microbattery is provided that has improved power density, energy density, and cycle lifetimes. These improvements are afforded by providing a solid-state electrolyte that is composed of crystalline Li1+xAlxTi2−x(PO4)3, wherein x is from 0 to 2. The solid-state electrolyte that is composed of crystalline Li1+xA1xTi2−x(PO4) has a high ionic conductivity (which is greater than 10−4 Siemens/cm) as well as high chemical stability.

公开(公告)号：US20190143095A1

公开(公告)日：2019-05-16

申请号：US15811023

申请日：2017-11-13

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Steven J. Holmes ,  Qinghuang Lin ,  Emily R. Kinser ,  Nathan P. Marchack ,  Roy R. Yu

IPC: A61N1/04 ,  A61K38/18 ,  B82Y15/00 ,  A61B5/00

Abstract: A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.

公开(公告)号：US20190131346A1

公开(公告)日：2019-05-02

申请号：US15798816

申请日：2017-10-31

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin

IPC: H01L27/22 ,  H01L43/02 ,  H01L43/08 ,  H01L43/12 ,  H01L21/768 ,  G11C11/16

Abstract: A method of forming a device that includes encapsulating a magnetic resistive access memory (MRAM) stack with a first patternable low-k dielectric material that is patterned by a exposure to produce a via pattern that extends to circuitry to logic devices. The via pattern is developed forming a via opening. The method further includes forming a second patternable low-k dielectric material over first patternable low-k dielectric material and filling the via opening. The second patternable low-k dielectric material is patterned by a light exposure to produce a first line pattern to the MRAM stack and a second line pattern to the via opening. The first line pattern and the second line pattern are developed to form trench openings. Thereafter, electrically conductive material is formed in the trench openings and the via opening.

公开(公告)号：US10170698B2

公开(公告)日：2019-01-01

申请号：US15590545

申请日：2017-05-09

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Anthony J. Annunziata ,  Armand A. Galan ,  Steve Holmes ,  Eric A. Joseph ,  Gen P. Lauer ,  Qinghuang Lin ,  Nathan P. Marchack

IPC: G03F7/20 ,  H01L43/12 ,  H01L43/10 ,  H01L43/02 ,  H01L43/08 ,  G11C11/16 ,  H01L27/22

Abstract: A method of forming a pillar includes masking a photoresist material using a reticle and a developer having a polarity opposite that of the photoresist to provide an island of photoresist material. A layer under the island of photoresist material is etched to establish a pillar defined by the island of photoresist material.