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    Latching micro-regulator
    31.
    发明申请
    Latching micro-regulator 有权
    闭锁微调节器

    公开(公告)号：US20050166975A1

    公开(公告)日：2005-08-04

    申请号：US11099014

    申请日：2005-04-04

    申请人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    发明人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

    IPC分类号： F15C5/00 ,  F16K99/00 ,  G05D7/06

    CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0069 ,  F16K2099/0071 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/87314

    摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.

    摘要翻译： 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板，限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体，并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁，用于移动悬臂梁的致动器（例如压电元件）以及用于固定悬臂的闩锁（例如永磁体） 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。

    COMPRESSION ASSEMBLY
    32.
    发明申请
    COMPRESSION ASSEMBLY 审中-公开
    压缩装配

    公开(公告)号：US20130085428A1

    公开(公告)日：2013-04-04

    申请号：US13249338

    申请日：2011-09-30

    申请人： Manish Deshpande

    发明人： Manish Deshpande

    IPC分类号： A61H7/00

    CPC分类号： A61H9/0092 ,  A61H2201/0107 ,  A61H2201/0192 ,  A61H2201/165 ,  A61H2201/5002 ,  A61H2205/06 ,  A61H2205/10 ,  A61H2209/00

    摘要： A compression assembly is adapted for placement on a body part for imparting compression therapy to the body part. The compression assembly includes a bladder and a bladder support. The bladder support and bladder have corresponding connection structure for mounting the bladder on the bladder support. In certain embodiments, the bladder is held in tension when mounted on the bladder support. In certain embodiments, the bladder support includes protrusions adapted for push-in reception in openings on the bladder for mounting the bladder on the bladder support, the bladder support is adjustable in length, and the bladder is foldable for adjusting the length of the bladder. Removable mounting of the bladder on the bladder support enables selective disposal of the bladders and bladder supports and interchangeability of different types of bladders with particular bladder supports.

    摘要翻译： 压缩组件适于放置在身体部分上以对身体部分进行压缩治疗。 压缩组件包括气囊和气囊支撑件。 膀胱支架和囊具有相应的连接结构，用于将膀胱安装在膀胱支撑上。 在某些实施例中，当安装在膀胱支撑体上时，膀胱保持张力。 在某些实施例中，气囊支撑件包括适于在气囊上的开口中进行推入接收的突起，用于将气囊安装在气囊支撑件上，气囊支撑件可在长度上调节，并且气囊可折叠以调节膀胱的长度。 膀胱可拆卸地安装在膀胱支架上，可以选择性地处理膀胱和膀胱支架以及不同类型的气囊与特定膀胱支架的互换性。

    METHOD AND APPARATUS FOR SORTING PARTICLES
    33.
    发明申请
    METHOD AND APPARATUS FOR SORTING PARTICLES 审中-公开
    分离颗粒的方法和装置

    公开(公告)号：US20110005978A1

    公开(公告)日：2011-01-13

    申请号：US12821790

    申请日：2010-06-23

    申请人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B03B5/00

    CPC分类号： G01N15/1459 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N2015/149

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

    Actuation of parallel microfluidic arrays
    37.
    发明授权
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US08863962B2

    公开(公告)日：2014-10-21

    申请号：US13371277

    申请日：2012-02-10

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00 ,  B07C5/34 ,  B01L3/00

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    CATHETER WITH TAPERING SURFACES
    38.
    发明申请
    CATHETER WITH TAPERING SURFACES 审中-公开
    带剪刀表面的导管

    公开(公告)号：US20130085477A1

    公开(公告)日：2013-04-04

    申请号：US13248548

    申请日：2011-09-29

    申请人： Manish Deshpande

    发明人： Manish Deshpande

    IPC分类号： A61M25/14

    CPC分类号： A61M25/007 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/3659 ,  A61M1/3661 ,  A61M25/003 ,  A61M2025/0031 ,  A61M2025/0073

    摘要： A catheter has an elongated tubular body and a septum. The elongated tubular body defines a longitudinal axis and includes a first wall defining a first lumen and a second wall defining a second lumen. The first lumen and the second lumen communicate with first and second distal openings, respectively. The septum separates the first and second lumens. One or both of the first and second walls includes a side opening. The side opening is fluid communication with one of the first and second lumens. The side opening has an external aperture and an internal aperture. The internal aperture is smaller in dimension than the external aperture.

    摘要翻译： 导管具有细长的管状体和隔膜。 细长管状体限定纵向轴线并且包括限定第一内腔的第一壁和限定第二腔的第二壁。 第一腔和第二腔分别与第一和第二远端开口连通。 隔膜分隔第一和第二腔。 第一和第二壁中的一个或两个包括侧开口。 侧开口与第一和第二腔之一流体连通。 侧面开口具有外部孔径和内部孔径。 内部孔径的尺寸小于外部孔径。

    REAL TIME INTRAVASCULAR MONITORING DEVICE
    39.
    发明申请
    REAL TIME INTRAVASCULAR MONITORING DEVICE 有权
    实时血管内监测装置

    公开(公告)号：US20130035564A1

    公开(公告)日：2013-02-07

    申请号：US13195287

    申请日：2011-08-01

    申请人： Manish Deshpande ,  Terri A. Kapur

    发明人： Manish Deshpande ,  Terri A. Kapur

    IPC分类号： A61B5/145

    CPC分类号： A61B5/145 ,  A61B5/6852 ,  A61B10/04 ,  A61B2010/045 ,  A61B2562/028

    摘要： A real time tissue sampling and analysis system includes a catheter including an elongated body defining at least one internal lumen, a sampling device positionable within the at least one internal lumen of the catheter for collecting a tissue sample, and a biochip disposed within the at least one internal lumen. The biochip includes a substrate for receiving the tissue sample, a marker for interacting with the tissue sample, and a sensor for identifying a characteristic of the tissue sample and transmitting data about the tissue sample to a processing unit for analysis.

    摘要翻译： 实时组织采样和分析系统包括导管，其包括限定至少一个内腔的细长主体，可定位在导管的至少一个内腔内用于收集组织样本的采样装置，以及设置在至少一个内部腔内的生物芯片 一个内腔。 生物芯片包括用于接收组织样本的基底，用于与组织样本相互作用的标记，以及用于识别组织样本的特征并将关于组织样本的数据传送到处理单元进行分析的传感器。