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111 条记录 (耗时 0.041 秒)

    Molds for casting with customized internal structure to collapse upon cooling and to facilitate control of heat transfer
    31.
    发明授权
    Molds for casting with customized internal structure to collapse upon cooling and to facilitate control of heat transfer 有权
    用于具有定制内部结构的铸造模具在冷却时塌陷并且便于控制热传递

    公开(公告)号：US06629559B2

    公开(公告)日：2003-10-07

    申请号：US10131001

    申请日：2002-04-24

    申请人： Emanuel M. Sachs ,  Won B. Bang ,  Michael J. Cima

    发明人： Emanuel M. Sachs ,  Won B. Bang ,  Michael J. Cima

    IPC分类号： B22C902

    CPC分类号： B22C9/00 ,  B22C9/04 ,  B33Y80/00

    摘要： A new mold solves problems that arise from differential changes in geometry inherent to casting metal in a ceramic mold, by control of the internal morphology between the surfaces of the mold that face the casting, and that face the external environment. Layered fabrication techniques are used to create a ceramic mold. For example, an internal geometry composed of a cellular arrangement of voids may be created within the mold wall. Structures may be designed and fabricated so that the ceramic mold fails at an appropriate time during the solidification and/or cooling of the casting. Thus, the casting itself is not damaged. The mold fails to avoid rupture, or even distortion, of the casting. A thin shell of ceramic defines the casting cavity. This shell must be thin enough to fail due to the stresses induced (primarily compressive) by the metal next to it and partly adherent to it. A support structure is provided with a morphology that supports the thin shell that defines the casting geometry, yet that also fails as the casting solidifies and/or cools. Typically, the support structure is a skeletal network with voids therebetween. The skeletal elements may be struts, or sheets or both. At least the following two failure mechanisms may be exploited in the design of the support structure: bending in the structure; and under compressive loads, either by buckling of a support member or, breakage under compressive loading. The failure of the support structure may also be due to a combination of bending and compression.

    摘要翻译： 一种新的模具解决了陶瓷模具中铸造金属固有几何差异变化的问题，通过控制模具表面之间的内部形态以及面对外部环境的内部形态。 使用分层制造技术来制造陶瓷模具。 例如，可以在模具壁内形成由空隙的细胞布置构成的内部几何形状。 可以设计和制造结构，使得陶瓷模具在铸件的凝固和/或冷却期间在适当的时间失效。 因此，铸件本身不会损坏。 模具不能避免铸件的破裂或甚至变形。陶瓷的薄壳体限定铸造腔体。 这种外壳必须足够薄以致由于紧邻其上的金属（部分粘附在其上）的应力引起（主要是压缩）的应力而失效。 支撑结构具有支撑限定铸造几何形状的薄壳的形态，但是当铸件固化和/或冷却时也会失效。 通常，支撑结构是其间具有空隙的骨架网络。 骨架元件可以是支柱或片材或两者。至少在支撑结构的设计中可以利用以下两种故障机构：在结构中弯曲; 并且在压缩载荷下，通过支撑构件的弯曲或在压缩载荷下断裂。 支撑结构的故障也可能是由于弯曲和压缩的组合。

    Thermally-activated microchip chemical delivery devices
    33.
    发明授权
    Thermally-activated microchip chemical delivery devices 有权
    热敏微芯片化学输送装置

    公开(公告)号：US06527762B1

    公开(公告)日：2003-03-04

    申请号：US09638109

    申请日：2000-08-11

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    IPC分类号： A61K911

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

    摘要翻译： 提供Microchip输送装置，其控制释放分子的速率和时间，其中所述装置包括底物，所述基质中含有所述分子的至少一个储存器和位于所述分子上的所述储存器上的储存器盖，其中所述分子 在加热或冷却装置或其一部分足以破坏储存器盖时从储存器释放。 在优选实施例中，该装置包括集成在储存器中或安装在储存器附近的电阻器，当施加电流通过电阻器时，储存器的至少一个内容物热膨胀，蒸发，相变， 或经历热驱动反应，使得储存器盖由于机械应力而破裂。 在另一个优选实施例中，将电流施加到位于储存器盖上或附近的电阻器使得盖膨胀，收缩或经历相变，导致储存器盖的破裂。 储层可以含有多种药物或其他可变剂量的分子。 单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

    Preparation of highly textured oxide superconducting films from MOD precursor solutions
    36.
    发明授权
    Preparation of highly textured oxide superconducting films from MOD precursor solutions 失效
    从MOD前置解决方案制备高纹理氧化物超导膜

    公开(公告)号：US5231074A

    公开(公告)日：1993-07-27

    申请号：US510115

    申请日：1990-04-17

    申请人： Michael J. Cima ,  Paul McIntyre

    发明人： Michael J. Cima ,  Paul McIntyre

    IPC分类号： H01L39/24

    CPC分类号： H01L39/2451 ,  Y10S505/734

    摘要： Highly-textured superconductor oxide thin films are prepared on substrates, including lattice matched, non-lattice matThe Government has rights in this invention pursuant to contract Number MDA972-88-K0006 awarded by the U.S. Defense Advance Research Project Agency.

    摘要翻译： 通过金属有机沉积（MOD）在衬底上制备高纹理超导体氧化物薄膜，包括晶格匹配的，非晶格匹配的惰性和非惰性材料。 选择前体溶液组成以及加工温度和气氛以控制瞬态液相的存在。 以高度纹理化的形态和完全致密均匀的微观结构为特征的超导体氧化物膜在77°K时能够保持超过104A / cm 2的临界电流密度，当在非晶格匹配衬底上制备时，其临界电流密度超过106A / cm2，当在晶格匹配的基底上制备时。

    Device and Method for Sampling Bodily Fluid for Medical Analytes in Ultra Low Concentrations
    38.
    发明申请
    Device and Method for Sampling Bodily Fluid for Medical Analytes in Ultra Low Concentrations 有权
    用于超低浓度医用分析物体液取样的装置和方法

    公开(公告)号：US20140004503A1

    公开(公告)日：2014-01-02

    申请号：US13977108

    申请日：2011-12-30

    申请人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

    发明人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

    IPC分类号： G01N1/34

    CPC分类号： G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

    摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

    摘要翻译： 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置以获得医用分析物的存在。

    Electrochemical actuator
    39.
    发明授权
    Electrochemical actuator 有权
    电化学执行器

    公开(公告)号：US08604664B2

    公开(公告)日：2013-12-10

    申请号：US13542179

    申请日：2012-07-05

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： H01L41/08

    CPC分类号： F03G7/005 ,  H01M10/052

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    摘要翻译： 本发明提供了涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

    IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS
    40.
    发明申请
    IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS 审中-公开
    可植入药物递送装置和方法

    公开(公告)号：US20130324946A1

    公开(公告)日：2013-12-05

    申请号：US13910730

    申请日：2013-06-05

    申请人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    发明人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    IPC分类号： A61L31/06 ,  A61L31/16

    CPC分类号： A61L31/06 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00 ,  A61M31/002 ,  C08L83/04 ,  C08L67/00

    摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.

    摘要翻译： 提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。 在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。 药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。 在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。