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53 条记录 (耗时 0.033 秒)

    Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
    33.
    发明授权
    Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease 失效
    用于筛选有效治疗或预防阿尔茨海默病的转基因动物和细胞系

    公开(公告)号：US07226730B1

    公开(公告)日：2007-06-05

    申请号：US09380203

    申请日：1998-02-26

    申请人： Suzanne De La Monte ,  Jack R. Wands

    发明人： Suzanne De La Monte ,  Jack R. Wands

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/5058 ,  G01N2800/2821

    摘要： Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.

    摘要翻译： 公开了表达与阿尔茨海默氏病，神经外胚层肿瘤，恶性星形细胞瘤和成胶质细胞瘤相关的蛋白质的转基因动物和转染的细胞系。 还公开了使用这样的转基因动物和转染的细胞系筛选用于治疗或预防阿尔茨海默病，神经外胚层肿瘤，恶性星形细胞瘤和成胶质细胞瘤的潜在药物候选物。 本发明还涉及可用于治疗或预防阿尔茨海默氏病，神经外胚层肿瘤，恶性星形细胞瘤和胶质母细胞瘤的新型反义寡核苷酸，核酶，形成三链体的三链体和外部引导序列。

    Chimeric hepatitis B/hepatitis C virus vaccine
    34.
    发明授权
    Chimeric hepatitis B/hepatitis C virus vaccine 失效
    嵌合型乙肝/丙型肝炎病毒疫苗

    公开(公告)号：US06025341A

    公开(公告)日：2000-02-15

    申请号：US854531

    申请日：1997-05-12

    申请人： Jack R. Wands ,  Katsutoshi Tokushige ,  Takaji Wakita

    发明人： Jack R. Wands ,  Katsutoshi Tokushige ,  Takaji Wakita

    IPC分类号： A61K39/29 ,  A61K39/00 ,  A61K48/00 ,  C07K14/00 ,  C07K14/02 ,  C07K14/18 ,  C12N15/11 ,  C12N15/51 ,  C12N15/62

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2730/10122 ,  C12N2770/24222

    摘要： Nucleic acid molecule that comprise an incomplete hepatitis C and hepatitis B viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.

    摘要翻译： 公开了包含不完全丙型肝炎和乙型肝炎病毒基因组的核酸分子，包括具体公开的DNA序列。 公开了含有包含不完全丙型肝炎和乙型肝炎病毒基因组的核酸分子的药物组合物，包括编码完整丙型肝炎核心蛋白的核苷酸序列和可操作地连接到人类细胞中的调节元件的乙型肝炎S基因蛋白。 公开了对乙型肝炎病毒和/或丙型肝炎病毒感染或感染的个体进行免疫的方法，包括施用该药物组合物的步骤。

    Method for the detection of a polypeptide subunit in the presence of a quaternary protein containing the subunit
    37.
    发明授权
    Method for the detection of a polypeptide subunit in the presence of a quaternary protein containing the subunit 失效
    在含有亚基的季蛋白存在下检测多肽亚基的方法

    公开(公告)号：US4933275A

    公开(公告)日：1990-06-12

    申请号：US791114

    申请日：1985-10-24

    申请人： Jack R. Wands ,  Mehmet Ozturk ,  Dominique Bellet

    发明人： Jack R. Wands ,  Mehmet Ozturk ,  Dominique Bellet

    IPC分类号： C07K14/195 ,  C07K14/005 ,  C07K14/575 ,  C07K16/00 ,  C07K16/26 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577

    CPC分类号： C07K16/26 ,  Y10S435/81 ,  Y10S435/975 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818

    摘要： A method for the determination of a free protein subunit of a quaternary protein in a sample, which comprises:(a) contacting a sample with a first immunological binding partner which is or will be bound to a carrier, wherein the first immunological binding partner binds epitopic determinants bindable only on the free protein subunit;(b) incubating the components of step (a) for a period of time and under conditions sufficient to form an immune complex between the free protein subunit, the first immunological binding partner, and the carrier;(c) separating the carrier of step (b) from the sample;(d) adding to the carrier of step (c), a detectably-labeled second immunological binding partner, wherein the second immunological binding partner binds epitopic determinants bindable on both the free protein subunit and the quaternary protein; and(e) determining the detectably-labeled second immunological binding partner in the carrier or in liquid phase.

    摘要翻译： 一种用于测定样品中季蛋白质的游离蛋白质亚基的方法，其包括：（a）使样品与第一免疫结合配偶体接触，所述第一免疫结合配偶体与载体结合或将结合到载体上，其中所述第一免疫结合配偶体结合 仅在游离蛋白亚基上结合的表位决定簇; （b）将步骤（a）的组分在足以在游离蛋白质亚基，第一免疫结合配偶体和载体之间形成免疫复合物的条件下孵育一段时间; （c）将步骤（b）的载体与样品分离; （d）向步骤（c）的载体添加可检测标记的第二免疫结合配偶体，其中所述第二免疫结合配偶体结合可结合游离蛋白质亚基和季蛋白的表位决定簇; 和（e）确定载体中或液相中的可检测标记的第二免疫结合配偶体。

    Wnt Proteins and Detection and Treatment of Cancer
    40.
    发明申请
    Wnt Proteins and Detection and Treatment of Cancer 审中-公开
    Wnt蛋白和癌症的检测与治疗

    公开(公告)号：US20100203054A1

    公开(公告)日：2010-08-12

    申请号：US12701425

    申请日：2010-02-05

    申请人： Jack R. Wands ,  Miran Kim

    发明人： Jack R. Wands ,  Miran Kim

    IPC分类号： A61K39/395 ,  A61P35/00 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/57438 ,  G01N33/5011 ,  G01N2500/04

    摘要： The present specification provides, inter alia, methods of using Wnt and FZD proteins and genes, and Wnt- and FZD-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.

    摘要翻译： 本说明书尤其提供了使用Wnt和FZD蛋白质和基因以及Wnt和FZD特异性抗体和探针来诊断和治疗癌症以及筛选化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。