公开(公告)号：US20070142658A1

公开(公告)日：2007-06-21

申请号：US10591964

申请日：2005-03-07

Applicant: Shu Kobayashi

Inventor： Shu Kobayashi

IPC: C07F9/02

CPC classification number: B01J31/1805 ,  B01J2531/16 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056

Abstract: To present a reaction system that efficiently catalyzes an enantio selective asymmetric nucleophilic addition reaction of an α-iminophosphonic acid ester. An optically active α-amino-γ-oxophosphonic acid derivative is produced through an asymmetric addition reaction of an α-iminophosphonic acid ester and a nucleophilic agent (for example, a silyl enol ether).

Abstract translation: 提出有效催化α-亚氨基膦酸酯的对映选择性不对称亲核加成反应的反应体系。 通过α-亚氨基膦酸酯和亲核剂（例如甲硅烷基烯醇醚）的不对称加成反应产生光学活性的α-氨基-γ-氧代膦酸衍生物。

公开(公告)号：US20060019822A1

公开(公告)日：2006-01-26

申请号：US10527699

申请日：2003-09-01

Applicant: Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

Inventor： Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

IPC: B01J31/00 ,  C07F17/02

CPC classification number: B01J31/06 ,  B01J2231/44 ,  B01J2231/645 ,  B01J2231/70 ,  C07B2200/11 ,  C07C17/16 ,  C07C41/16 ,  C07C45/29 ,  C07C45/62 ,  C07C67/343 ,  C07D303/16 ,  C07F15/006 ,  C07F15/0066 ,  C07C22/04 ,  C07C47/232 ,  C07C49/213 ,  C07C69/618 ,  C07C43/215

Abstract: The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol. The catalyst composition of the present invention can be safely and easily handled without danger of spontaneous ignition, and the like, and is extremely useful as a catalyst for various chemical reactions, and further activity thereof is not decreased by repeated use thereof and a metal catalyst does not leak from a polymer compound which is a carrier thereof.

Abstract translation: 本发明公开了1）由交联的有机高分子化合物和钯催化剂组成的催化剂组合物，其中所述催化剂物理地携带在所述交联的有机高分子化合物上，2）上述催化剂组合物1）的制备方法，其特征在于均化 具有可交联官能团的直链有机高分子化合物和溶解所述直链有机高分子化合物的溶剂中的钯催化剂，然后沉积由此形成的组合物，并对所述沉积物中的可交联官能团进行交联反应; 3） 在烯丙基位置进行取代反应的方法，其特征在于在上述催化剂组合物1）的存在下使碳酸烯丙酯和亲核试剂反应，和4）一种氧化醇的方法，其特征在于将上述催化剂组合物1） 与酒精反应。 本发明的催化剂组合物可以安全，容易地处理而没有自发点火的危险等，并且作为各种化学反应的催化剂是非常有用的，并且通过反复使用和金属催化剂不会降低其进一步的活性 不会从作为其载体的高分子化合物泄漏。

公开(公告)号：US20050267315A1

公开(公告)日：2005-12-01

申请号：US11194554

申请日：2005-08-02

Applicant: Shu Kobayashi

Inventor： Shu Kobayashi

IPC: C07B61/00 ,  C07C231/12 ,  C07C233/33 ,  C07C233/76 ,  C07C269/06 ,  C07C271/28 ,  C07C303/40 ,  C07C311/08 ,  C07C227/08

CPC classification number: C07C269/06 ,  C07C231/12 ,  C07C303/40 ,  C07C311/08 ,  C07C233/33 ,  C07C271/28

Abstract: An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.

Abstract translation: 通过在周期表第4-6周期中使用属于3至5族和13至15族的任何元素的三（全氟烷基磺酸酯）化合物作为催化剂使酰苯胺与酰化剂反应，从而将酰基 组成苯环。 因此，作为生理活性化合物或其合成中间体的酮苯胺衍生物通过催化酰化以高反应收率合成。

公开(公告)号：US06525227B1

公开(公告)日：2003-02-25

申请号：US09762102

申请日：2001-04-04

Applicant: Shu Kobayashi

Inventor： Shu Kobayashi

IPC: C07C4500

CPC classification number: C07C45/72 ,  B01J27/10 ,  B01J27/125 ,  B01J35/002 ,  B01J2531/96 ,  C07C45/511 ,  C07C49/83

Abstract: A reaction method by a novel Lewis acid catalyst stable in water for organic synthesis by using a metal compound stable in water and functioning as a Lewis acid catalyst and using water as apart or all of a solvent, the metal ion of the metal compound having a hydrolysis constant (pKh) of: 4.3≦pKh≦10.1 and a water exchange rate constant (WERC) of 3.2×106M−1sec−1 or more.

Abstract translation: 一种通过使用在水中稳定并用作路易斯酸催化剂并用作分离或全部溶剂的水的金属化合物在水中稳定用于有机合成的新型路易斯酸催化剂的反应方法，金​​属化合物的金属离子具有 水解常数（pKh）为：4.3 <= pKh <= 10.1，水交换率常数（WERC）为3.2×106M-1sec-1以上。

公开(公告)号：US06420372B1

公开(公告)日：2002-07-16

申请号：US09674362

申请日：2000-12-22

Applicant: Shu Kobayashi ,  Yusuke Wataya ,  Hye-Sook Kim

Inventor： Shu Kobayashi ,  Yusuke Wataya ,  Hye-Sook Kim

IPC: A01N4354

CPC classification number: C07D401/06 ,  A61K31/517 ,  C07D491/04 ,  Y02A50/411

Abstract: A febrifugine represented by Formula (A): and an isofebrifugine represented by Formula (B): which exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.

Abstract translation: 提供由式（A）表示的分枝杆菌和由式（B）表示的异苯乙酸：与热带疟原虫相比表现出极强的活性，以及​​能够进行大规模合成的总合成路线。

公开(公告)号：US06417368B1

公开(公告)日：2002-07-09

申请号：US09646042

申请日：2000-11-08

Applicant: Shu Kobayashi ,  Yoji Aoki

Inventor： Shu Kobayashi ,  Yoji Aoki

IPC: C07C25124

CPC classification number: C08F8/30 ,  C07B2200/11 ,  C07C227/10 ,  C07C227/16 ,  C07C229/28 ,  C07C229/34 ,  C07C251/24 ,  C07C327/22 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/74 ,  C40B40/00 ,  C40B50/14

Abstract: The invention provides a resin-immobilized imine represented by the following formula: P—Q—N—═CH—R   I [in the formula, P represents the principal chain of a resin polymer; Q represents a substituted or unsubstituted hydrocarbon side chain or a substituted or unsubstituted hydrocarbon side chain with a heteroatom interposed therein; R represents a substituted or unsubstituted hydrocarbon group or heterocyclic group] and a resin-immobilized &bgr;-aminocarbonyl compound of the following formula: which can be released as &bgr;-aminocarbonyl compound from the solid phase; and the invention also provide a resin-immobilized amine of the following formula: —P—Q1—O—Q2—NH2   III [Q1 and Q2 independently represent a hydrocarbon chain such as arylene, alkylenearylene or arylenealkylene], which is essential for solid state synthesis; and the invention has enabled the solid state synthesis of &bgr;-aminocarbonyl compound by the application of iminoaldol reaction.

Abstract translation: 本发明提供由下式表示的固化有树脂的亚胺：[式中，P表示树脂聚合物的主链; Q表示取代或未取代的烃侧链或其中插入有杂原子的取代或未取代的烃侧链; R表示取代或未取代的烃基或杂环基]和下式的树脂固定的β-氨基羰基化合物：其可从固相作为β-氨基羰基化合物释放; 本发明还提供下式的树脂固定胺：[Q1和Q2独立地表示烃链如亚芳基，亚烷基亚芳基或亚芳基亚烷基]，这对于固态合成是必需的; 本发明通过应用亚氨基醛醇反应使得β-氨基羰基化合物的固态合成成为可能。

公开(公告)号：US06376419B1

公开(公告)日：2002-04-23

申请号：US09930265

申请日：2001-08-16

Applicant: Shu Kobayashi

Inventor： Shu Kobayashi

IPC: B01J3100

CPC classification number: C07C29/48 ,  B01J13/06 ,  B01J23/466 ,  B01J31/06 ,  B01J31/165 ,  B01J31/1805 ,  B01J31/183 ,  B01J31/2226 ,  B01J31/4038 ,  B01J2231/70 ,  B01J2531/825 ,  C07B2200/07 ,  C07C2601/14 ,  C07C2601/18 ,  Y02P20/584 ,  Y10S502/507 ,  Y10T428/249991 ,  Y10T428/249992 ,  Y10T428/249993 ,  Y10T428/256 ,  Y10T428/29 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998 ,  C07C31/20 ,  C07C35/20 ,  C07C35/14 ,  C07C33/26

Abstract: The present invention provides an osmium oxide composition comprising an osmium oxide microencapsulated in an aromatic polyolefin (hereinafter abbreviated as MCOsOx), a method for preparation of MCOsOx, which comprises allowing an osmium oxide to contact with an aromatic polyolefin in an organic solvent, and precipitating MCOsOx, an oxidizing agent comprising MCOsOx, a method for preparing a chiral diol compound, which comprises reacting MCOsOx, a chiral ligand and an olefin compound with each other, and a method for preparing a chiral diol compound, which comprises oxidizing an olefin compound with MCOsOx, wherein a chiral ligand further coordinates to an osmium oxide.

Abstract translation: 本发明提供一种氧化锇组合物，其包含微胶囊化在芳族聚烯烃（以下简称为MCOsOx）中的氧化锇，制备MCO x O x的方法，其包括使锇氧化物与有机溶剂中的芳族聚烯烃接触， MCOsOx，包含MCO 3 O x的氧化剂，制备手性二醇化合物的方法，其包括使MCO x O x，手性配体和烯烃化合物彼此反应，以及制备手性二醇化合物的方法，其包括用烯烃化合物 MCO x O x，其中手性配体进一步与氧化锇配位。

公开(公告)号：US08871668B2

公开(公告)日：2014-10-28

申请号：US12282444

申请日：2007-03-12

Applicant: Shu Kobayashi ,  Yuichiro Mori ,  Gu Yanlong

Inventor： Shu Kobayashi ,  Yuichiro Mori ,  Gu Yanlong

IPC: B01J31/22 ,  B01J31/02 ,  B01J31/16 ,  C07C327/22 ,  C07C29/40 ,  C07C221/00

CPC classification number: C07C29/40 ,  B01J31/0252 ,  B01J31/0254 ,  B01J31/0284 ,  B01J31/0288 ,  B01J31/0292 ,  B01J31/1633 ,  B01J31/2256 ,  B01J2231/32 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2531/35 ,  B01J2531/36 ,  B01J2531/38 ,  B01J2531/54 ,  B01J2531/96 ,  C07C221/00 ,  C07C327/22 ,  Y02P20/588 ,  C07C225/18 ,  C07C33/30

Abstract: The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis acid catalyst comprising a solid substance and a Lewis acid supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are coated with an ionic liquid, more specifically, an immobilized Lewis acid catalyst comprising a solid substance such as silica gel or an organic polymer and a Lewis acid stable even in water which is supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are completely or partially coated with a hydrophobic ionic liquid; a process for the production of the catalyst; use thereof; and a process for the preparation of compounds with the catalyst.

Abstract translation: 本发明提供了一种在水溶液中显示出高催化活性并且允许回收和再利用或长期连续使用的新型固定化路易斯酸催化剂。 本发明涉及一种固定化的路易斯酸催化剂，其包含通过化学键合负载在固体物质的表面上的固体物质和路易斯酸，其中固体物质的表面和路易斯酸的外围被离子液体包覆， 更具体地，包含固体物质如硅胶或有机聚合物的固化的路易斯酸催化剂和即使在水中稳定的路易斯酸，其通过化学键合负载在固体物质的表面上，其中固体物质的表面和 路易斯酸的外围部分被完全或部分地涂覆有疏水性离子液体; 催化剂的生产方法; 使用; 以及用催化剂制备化合物的方法。

公开(公告)号：US20130059999A1

公开(公告)日：2013-03-07

申请号：US13580312

申请日：2011-02-16

Applicant: Shu Kobayashi ,  Hiroyuki Miyamura

Inventor： Shu Kobayashi ,  Hiroyuki Miyamura

IPC: C08F28/02 ,  C07C45/00

CPC classification number: C07D455/04 ,  B01J23/52 ,  B01J31/0227 ,  B01J31/0228 ,  B01J31/165 ,  B01J31/226 ,  B01J35/0013 ,  B01J2231/326 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/4205 ,  B01J2531/0222 ,  B01J2531/18 ,  B01J2531/35 ,  B01J2540/325 ,  B01J2540/345 ,  C07C45/75 ,  C07D491/22 ,  C07C49/82

Abstract: The present invention provides a Scandium catalyst that can be used in water or water-soluble organic solvent with no leaching of Scandium. Provided is a gold-polymer nanostructure-immobilized Scandium catalyst, which is formed by preparing, in liquid phase, a mixture comprising gold clusters with from 1 to 50 nm of diameter, disulfide monomer, sulfonic acid salt of disulfide and Lewis acid metal compound represented by ScY3, wherein Y is OSO2CF3 etc., and polymerizing the mixture in the presence of a radical polymerization initiator, wherein the disulfide monomer is represented by the formula below: CH2═CH—R1—S—S—R1—CH═CH2 wherein R1 represents a divalent hydrocarbon, which may contain an ether bond, and the sulfonic acid salt of disulfide is represented by the formula below: MO3S—R2—S—S—R2—SO3M wherein R2 represents a divalent hydrocarbon, which may contain an ether bond, and M represents an alkali metal. This catalyst is useful as a catalyst for aldol reactions, cyanolation reactions, allylation reactions, Michael reactions, Mannich reactions, Diels Alder reactions and Friedel Crafts reactions in water or water-soluble organic solvent.

Abstract translation: 本发明提供了可用于水或水溶性有机溶剂中的钪催化剂，而不会浸出钪。 提供了一种金 - 聚合物纳米结构固定的钪催化剂，其通过在液相中制备包含直径为1至50nm的金簇的混合物，二硫化物单体，二硫化物磺酸盐和路易斯酸金属化合物 其中Y是OSO 2 CF 3等，并且在自由基聚合引发剂存在下聚合混合物，其中二硫化物单体由下式表示：CH 2 = CH-R 1 -S-S-R 1 -CH = CH 2其中 R1表示可以含有醚键的二价烃，二硫化物的磺酸盐由下式表示：MO 3 S-R 2 -S-S-R 2 -SO 3 M其中R 2表示可以含有醚的二价烃 键，M表示碱金属。 该催化剂可用作醛醇反应，硅烷醇化反应，烯丙基化反应，迈克尔反应，曼尼希反应，狄尔斯阿尔德反应和弗里德尔·卡夫在水或水溶性有机溶剂中的反应的催化剂。

公开(公告)号：US07667078B2

公开(公告)日：2010-02-23

申请号：US10589259

申请日：2005-03-09

Applicant: Shu Kobayashi ,  Haruro Ishitani ,  Yasuhiro Yamashita

Inventor： Shu Kobayashi ,  Haruro Ishitani ,  Yasuhiro Yamashita

IPC: C07C215/00

CPC classification number: B01J31/223 ,  B01J2231/341 ,  B01J2231/485 ,  B01J2531/0266 ,  B01J2531/57 ,  C07B53/00 ,  C07C221/00 ,  C07C327/22 ,  C07D307/54 ,  C07D333/24 ,  C07C225/06

Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).

Abstract translation: 通过混合五价铌化合物和具有R或S构型的联萘酚结构的光学活性三醇或四醇，得到不对称反应催化剂，三醇由下式表示：（其中，Y为二价烃，R1为 氢原子，卤素原子，三氟甲基或至多4个碳原子的烷基或烷氧基）。