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31.发明申请Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement 有权在可以通过线路访问的测量室中的液体测量样品上进行电化学测量的方法和相应的布置公开(公告)号：US20090136922A1
公开(公告)日：2009-05-28
申请号：US11665331
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Especially in order to carry out the so-called enzyme-coupled DNA hybridisation test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
摘要翻译： 特别是为了在包括微流体系统的封闭式筒体中进行所谓的酶偶联DNA杂交试验，使用储存的干试剂，试剂必须溶解在微流体系统中，并在测量前直接输送到测量室中。 在将试剂溶解在水中时，必须绝对防止不能到达测量室的气垫在试剂液体的上游形成。 根据本发明的一个实施例，液体测量样品和液体试剂以这样一种方式运输，使得气垫被引导到废液管线中，然后将测量样品和试剂引入测量室，而没有任何气泡 。 这样可以避免测量误差。
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32.发明申请Method for the Combined Isolation of Magnet-Beads From a Liquid Sample and Subsequent Thermocyclisation for the Polymerase Chain Reaction (Pcr) and Associated Arrangement 有权用于从液体样品中组合分离磁珠的方法和用于聚合酶链反应（Pcr）和相关布置的随后的热环化公开(公告)号：US20070264649A1
公开(公告)日：2007-11-15
申请号：US11665376
申请日：2005-10-14
CPC分类号： B01L7/52 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2300/1822 , B01L2400/0661 , G01N35/0098
摘要： Embodiments generally relate to a PCR wherein a magnetic field is focused in a localised area and also to the possibility of a cyclic transfer of heat. According to at least one embodiment of the invention, a magnetic field gradient is constructed along the direction of flow and the transfer of heat is carried out in a manner perpendicular to the direction of flow. Suitable things are provided therefore. The magnetic field is, in particular, focused by Mumetal® which is arranged on both sides of the flow channel and the temperature is controlled by way of Peltier elements, cooling bodies, and thermal coupling plates.
摘要翻译： 实施方案通常涉及PCR，其中磁场聚焦在局部区域中，并且还涉及循环传递热的可能性。 根据本发明的至少一个实施例，沿着流动方向构造磁场梯度，并且以垂直于流动方向的方式进行热传递。 因此提供合适的东西。 特别地，磁场被布置在流动通道两侧的Mumetal聚焦，并且温度通过珀耳帖元件，冷却体和热耦合板来控制。
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33.发明申请Method for the Production of a Solution, Associated Arrangement and Uses of the Method and Arrangement 有权解决方案的生产方法，相关安排和方法和安排的使用公开(公告)号：US20070212708A1
公开(公告)日：2007-09-13
申请号：US11587572
申请日：2005-04-26
CPC分类号： B01F15/0205 , B01F1/00 , B01F13/0059 , B01F15/021 , Y10T436/25
摘要： Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.
摘要翻译： 空腔中的固体物质用于在溶剂中产生至少一种固体物质的溶液。 首先被溶解在溶剂中的固体物质通过不溶于溶剂的介质在空腔中被包覆和/或包围，从而防止固体物质的溶解。 随后将溶剂引导到空腔中，并且不溶于溶剂的介质以在溶剂和可溶性固体物质之间接触使得固体物质溶解在溶剂中的方式被处理。 可以以有利的方式制备包含两种或更多种固体物质的溶液。
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34.发明申请Recognition layers made of hydrogel based on polyacrylamide for use in biosensor technology 审中-公开由基于聚丙烯酰胺的水凝胶制成的识别层用于生物传感器技术公开(公告)号：US20060111517A1
公开(公告)日：2006-05-25
申请号：US10523929
申请日：2003-07-23
IPC分类号： C08F220/56
CPC分类号： C12Q1/002
摘要： A hydrophilic immobilization layer for biosensors is made of a radically cross-linkable hydrogel based on polyacraylamide. The starting composition includes acrylamide, cross-linkers, radical initiator(s), at least one comonomer having reactive linker groups and optionally may include softeners. Alternatively, the inventive layer may be of a photostructured hydrogel based on polyacrylamide. The starting composition includes acrylamide, cross-linkers, photoinitiators, at least one film former, at least one comonomer having reactive linker groups and optionally may include softeners.
摘要翻译： 用于生物传感器的亲水性固定化层由基于聚酰胺的可自由基交联的水凝胶制成。 起始组合物包括丙烯酰胺，交联剂，自由基引发剂，至少一种具有反应性连接基团的共聚单体，并且任选地可以包括软化剂。 或者，本发明的层可以是基于聚丙烯酰胺的光结构的水凝胶。 起始组合物包括丙烯酰胺，交联剂，光引发剂，至少一种成膜剂，至少一种具有反应性连接基团的共聚单体，并且任选地可以包括软化剂。
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公开(公告)号：US10081831B2
公开(公告)日：2018-09-25
申请号：US12743316
申请日：2008-10-29
IPC分类号： C12Q1/68 , C12Q1/6837
CPC分类号： C12Q1/6837 , C12Q2527/107
摘要： A method is disclosed for calibrating a sensor element, which has an immobilized probe oligonucleotide, via which the bonding of a target nucleic acid (Z) can be detected by the sensor. In at least one embodiment, the method includes: a) bringing the sensor element into contact with a control nucleic acid (K), the melting temperature Tm(K) of which is less than the melting temperature Tm(Z) of the target nucleic acid (Z); b) hybridizing the control nucleic acid (K) to the probe oligonucleotide at a temperature T[p] Tm(K) and detecting a negative control signal at a temperature T[n]. According to a refinement of at least one embodiment of the invention, a measuring signal of the target nucleic acid (Z) is measured at a measuring temperature T [mess], where Tm(K)
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36.发明授权Module for processing a biological sample, biochip kit, and use of the module 有权用于处理生物样品的模块，生物芯片套件和模块的使用公开(公告)号：US08771609B2
公开(公告)日：2014-07-08
申请号：US11653230
申请日：2007-01-16
IPC分类号： B01L3/00
CPC分类号： G01N1/40 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2300/0816 , G01N35/0098 , Y10T436/2575
摘要： A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.
摘要翻译： 公开了用于处理用于分析测试的生物样品的模块。 处理模块在至少一个实施例中包括接口，在该界面处，处理模块可以与芯片上的实验室连接，其中进行分析步骤。 还公开了一种生物芯片套件。 在至少一个实施例中，生物芯片套件包括一个或多个处理模块，其用于不同的样品材料并且可以连接到相同的盒式。
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公开(公告)号：US08753874B2
公开(公告)日：2014-06-17
申请号：US10540208
申请日：2003-12-15
申请人： Walter Gumbrecht , Manfred Stanzel
发明人： Walter Gumbrecht , Manfred Stanzel
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C02F1/40 , B03C5/02 , G01N15/06 , G01N27/00 , G01N33/00 , C07H21/02
CPC分类号： C12M1/34 , G01N27/026 , G01N33/5438
摘要： A biochip includes a flat carrier and an array of spots containing catcher molecules which are arranged on the carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the catcher molecules and the target molecules applied via an analyte solution. In order to increase the sensitivity or the binding-specific measuring effects of the bio-chip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing catcher molecules and which is permeable to target molecules.
摘要翻译： 生物芯片包括平坦载体和布置在载体上的含有捕获剂分子的斑点阵列。 每个点与微电极布置相关联，用于阻抗光谱检测在捕获剂分子与通过分析物溶液施加的靶分子之间发生的结合事件。 为了提高生物芯片的灵敏度或结合特异性的测量效果，电极布置至少部分地嵌入含有捕获剂分子的亲水反应层中，并且其对靶分子是可渗透的。
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公开(公告)号：US20140110349A1
公开(公告)日：2014-04-24
申请号：US14118728
申请日：2012-04-13
申请人： Joachim Bangert , Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka , Manfred Stanzel
发明人： Joachim Bangert , Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka , Manfred Stanzel
CPC分类号： A61M1/34 , A61M1/3403 , B01D61/18 , B01D61/22 , B01D67/0032 , B01D71/50 , B01D2311/14 , G01N33/491 , G01N2001/4088
摘要： An assembly and a method for filtration are disclosured, which are suitable in particular for the filtration of cells, for example tumor cells, from a sample, for example a blood sample. In the method, a pressure differential between the pressure upstream and the pressure downstream of a filter is determined; and the pressure differential between upstream and downstream of the filter is adjusted such that the pressure differential does not exceed a predetermined value.
摘要翻译： 公开了组合物和过滤方法，其特别适用于从样品例如血液样品过滤细胞，例如肿瘤细胞。 在该方法中，确定过滤器下游压力和压力之间的压力差; 并且调节过滤器的上游和下游之间的压力差，使得压差不超过预定值。
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39.发明申请公开(公告)号：US20120252055A1
公开(公告)日：2012-10-04
申请号：US13499376
申请日：2010-09-29
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
CPC分类号： G01N27/416 , C12M41/38 , C12M41/46 , G01N27/404 , G01N27/423 , G01N33/48735
摘要： An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.
摘要翻译： 一种安排和方法用传感器阵列测量细胞活力。 传感器阵列形成在半导体芯片的表面上。 半导体芯片具有集成电路，并且集成电路与传感器阵列的每个传感器相关联，用于处理相应传感器的测量信号。 集成电路在空间上形成在半导体芯片中，在每个情况下在相关传感器下方，并且传感器阵列的相邻传感器具有在微米范围内的中心到中心。 pH和/或pO2可以在活细胞的环境中测量。
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公开(公告)号：US07932082B2
公开(公告)日：2011-04-26
申请号：US11599424
申请日：2006-11-15
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
CPC分类号： B01L3/502715 , A61B10/0051 , A61B10/0096 , B01L3/502738 , B01L3/502761 , B01L3/5029 , B01L2200/027 , B01L2300/042 , B01L2400/0478 , B01L2400/0633 , G01N2001/028
摘要： A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.
摘要翻译： 公开了一种用于提取涂片样品的装置。 该装置包括可以引入携带涂片样品的样品载体的空腔。 可以通过连接到空腔的至少一个液体进料将液体引入空腔中，并且可以通过连接到空腔的至少一个液体排出物从腔中去除液体。
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