公开(公告)号：US5472590A

公开(公告)日：1995-12-05

申请号：US354643

申请日：1994-12-13

申请人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

发明人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

IPC分类号： G01N27/333 ,  G01N27/414 ,  G01N27/26

CPC分类号： G01N27/414 ,  G01N27/3335

摘要： An ion sensor having an ion selectivity, which comprises an internal electrode of metal/metal salt, composed of an electroconductive layer of at least one metal and a layer of an insoluble salt of the metal in contact with the electroconductive layer, an ion selective membrane whose supporting membrane is composed of a hydrophobic polymer, and an intermediate layer capable of keeping water molecules, provided between the internal solid electrode and the ion selective membrane, where the organic compound having a water-keeping property is polymethylene glycol, polyethylene glycol or polypropylene glycol, each having a molecular weight of 200 to 600, and the inorganic compound having a water-keeping property is calcium chloride, gold chloride, magnesium perchlorate, magnesium fluoride or vanadium chloride dioxide, is suitable for analysis of specific ion species in a biological fluid with practically prolonged maintenance of properties of electrode.

摘要翻译： 一种具有离子选择性的离子传感器，其包括金属/金属盐的内部电极，其由至少一种金属的导电层和与导电层接触的金属的不溶性盐层，离子选择性膜 其内部固体电极与离子选择性膜之间具有疏水性聚合物和能够保持水分子的中间层，其中具有保水性的有机化合物为聚亚甲基二醇，聚乙二醇或聚丙烯 乙二醇，分子量为200〜600，具有保水性的无机化合物为氯化钙，氯化金，高氯酸镁，氟化镁或二氯化钒，适用于分析生物中的特定离子种类 流体与电极性能几乎延长。

公开(公告)号：US5352352A

公开(公告)日：1994-10-04

申请号：US948646

申请日：1992-09-23

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/404 ,  A61B5/00 ,  G01N27/49 ,  G01N33/49

CPC分类号： A61B5/14542 ,  A61B5/14539 ,  A61B5/1468 ,  G01N27/4045 ,  G01N33/4925

摘要： A sensor for detecting a carbonic acid gas dissolved in body fluids has a laminated structure including an outer plate having a carbonic acid gas permeable window, a plate for a pH-electrode having a pH sensitive membrane, an intermediate plate having a cavity for accommodating an electrolyte, and a plate for a reference electrode. The plate for the pH-electrode is constituted in a manner that a pH sensitive membrane constituted by a membrane of an oxide of a platinum group metal is formed on an insulating substrate and the electrolyte contacts with the pH sensitive membrane in a groove. The pH sensitive membrane is disposed so as to oppose to the carbonic acid gas permeable window.

摘要翻译： 用于检测溶解在体液中的碳酸气体的传感器具有包括具有碳酸气体透过窗的外板，具有pH敏感膜的pH电极的板，具有用于容纳 电解质和用于参考电极的板。 用于pH电极的板构成为在绝缘基板上形成由铂族金属的氧化物的膜构成的pH敏感膜，电解液与沟槽中的pH敏感膜接触。 将pH敏感膜设置成与碳酸气体透过窗口相对。

公开(公告)号：US5132012A

公开(公告)日：1992-07-21

申请号：US369853

申请日：1989-06-22

申请人： Junkichi Miura ,  Andreas Manz ,  Yoshio Watanabe ,  Yuji Miyahara ,  Hiroyuki Miyagi ,  Keiji Tsukada

发明人： Junkichi Miura ,  Andreas Manz ,  Yoshio Watanabe ,  Yuji Miyahara ,  Hiroyuki Miyagi ,  Keiji Tsukada

IPC分类号： G01N30/18 ,  G01N30/32 ,  G01N30/38 ,  G01N30/60 ,  G01N30/64 ,  G01N35/00

CPC分类号： G01N30/6095 ,  G01N2030/385 ,  G01N2035/00237 ,  G01N30/18 ,  G01N30/32 ,  G01N30/64

摘要： A liquid chromatograph comprises an analyzing chip in which a capillary is formed in a substrate and a detector section is disposed downstream of the capillary. The capillary is covered so that an inlet opening end and an outlet opening end of said capillary flow path is opened. A frame member has a sample introduction path, a carrier liquid introduction path and a liquid discharge path. The analyzing chip is movably disposed in the frame member so that the inlet opening end and the outlet opening end of the capillary are selectively in communication with and/or under interruption against said sample introduction path, the carrier liquid introduction path and the liquid discharge path. The liquid chromatograph is very small in size but is easy to handle. Incidentally, there is disclosed also a sample introduction apparatus and method for the chromatograph, and an FET type detector suitable for the chromatograph.

摘要翻译： 液相色谱仪包括分析芯片，其中在基板中形成毛细管，并且检测器部分设置在毛细管的下游。 毛细管被覆盖，使得所述毛细管流路的入口开口端和出口开口端被打开。 框架构件具有样品引入路径，载液引入路径和液体排出路径。 分析芯片可移动地设置在框架构件中，使得毛细管的入口开口端和出口开口端选择性地与所述样品引入路径，载液引入路径和液体排出路径 。 液相色谱仪尺寸非常小，易于处理。 顺便提及，还公开了用于色谱仪的样品引入装置和方法，以及适用于色谱仪的FET型检测器。

公开(公告)号：US5093267A

公开(公告)日：1992-03-03

申请号：US267293

申请日：1988-11-04

申请人： Junkichi Miura ,  Mamoru Taki ,  Yoshio Watanabe ,  Masao Kamahori ,  Hiroyuki Miyagi

发明人： Junkichi Miura ,  Mamoru Taki ,  Yoshio Watanabe ,  Masao Kamahori ,  Hiroyuki Miyagi

IPC分类号： G01N30/06 ,  G01N30/88 ,  G01N33/94

CPC分类号： G01N33/9406 ,  G01N30/88 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/255

摘要： Catecholamines can be detected with high sensitivity in a shortened time period, by introducing a sample containing catecholamines into an adsorption column packed with an adsorbent to adsorb catecholamines to the column, then introducing a reagent for derivatization to effect pre-column labeling and then analyzing the pre-column labeled catecholamines by means of high performance liquid chromatography. Connection of the adsorption column and a separation column of high performance liquid chromatography via a fluid path changeover valve enables to automated analysis of catecholamines.

摘要翻译： 可以在缩短的时间内以高灵敏度检测儿茶酚胺，通过将含有儿茶酚胺的样品引入填充有吸附剂的吸附塔中将儿茶酚胺吸附到塔中，然后引入用于衍生化的试剂进行预柱标记，然后分析 通过高效液相色谱法预柱标记的儿茶酚胺。 通过流体路径切换阀连接吸附塔和高效液相色谱分离柱，可以自动分析儿茶酚胺。

公开(公告)号：US5005434A

公开(公告)日：1991-04-09

申请号：US390720

申请日：1989-08-08

申请人： Yoshio Watanabe ,  Mamoru Taki ,  Junkichi Miura ,  Masao Kamahori ,  Hiroyuki Miyagi ,  Yasuhide Matsumura ,  Masafumi Kanetomo

发明人： Yoshio Watanabe ,  Mamoru Taki ,  Junkichi Miura ,  Masao Kamahori ,  Hiroyuki Miyagi ,  Yasuhide Matsumura ,  Masafumi Kanetomo

IPC分类号： G01N35/10 ,  G01N1/00 ,  G01N1/14 ,  G01N15/00 ,  G01N30/16 ,  G01N30/24 ,  G01N30/34

CPC分类号： G01N35/1097 ,  G01N1/14 ,  G01N2015/0011 ,  G01N2021/4735 ,  G01N2201/08 ,  G01N30/34

摘要： An autosampler consists of a needle to draw specimen from a specimen container into a passage therein; a block having a passage that follows the passge in the needle; a suction mechanism for drawing in the specimen by suction through the passages in the needle and the block; a discharge mechanism for discarding the specimen drawn in by the suction mechanism; and a detecting device for detecting air bubble in the specimen, the detecting device being embedded in the block in such a manner as to face the passage in the block. The detecting device detects the air bubbles in the specimen according to changes in physical or chemical properties of the specimen passing through the passage in the block. The discharge mechanism is activated by the detecting device to discharge air-mixed specimen. When even a small amount of air is drawn into the passage from the specimen container, in which only a small amount of specimen is contained, the air specimen can reliably be distinguished from normal specimen by this autosampler. Therefore the reliability of the system using the autosampler can be significantly improved.

摘要翻译： 自动进样器由将样本从样本容器拉入其中的通道的针头组成; 具有跟随针头中的传递的通道的块; 抽吸机构，用于通过抽吸通过针和块中的通道抽吸样品; 用于废弃由抽吸机构吸入的试样的排出机构; 以及用于检测样本中的气泡的检测装置，所述检测装置以面对块中的通道的方式嵌入块中。 检测装置根据通过块体中的通道的试样的物理或化学特性的变化来检测样品中的气泡。 排出机构由检测装置启动，以排出空气混合样品。 即使少量的空气从容纳少量试样的试样容器的通道中吸入，也可以通过该自动进样器将空气样本与正常试样区分开。 因此，可以显着提高使用自动进样器的系统的可靠性。

公开(公告)号：US4970607A

公开(公告)日：1990-11-13

申请号：US389812

申请日：1989-08-04

申请人： Masanori Itagaki ,  Yoshio Watanabe

发明人： Masanori Itagaki ,  Yoshio Watanabe

IPC分类号： H04N1/028 ,  H01L27/14 ,  H04N1/031

CPC分类号： H04N1/0315 ,  H04N1/0313

摘要： A full-size image sensor includes a plurality of photoelectric conversion elements formed on a substrate and arranged into a line. A photosensitive surface of each of the photoelectric conversion elements is perpendicular to a document to be scanned. A transparent layer is formed on the substrate so as to cover the photoelectric conversion elements. A light reflecting layer made of a light interrupting member is formed on the transparent layer so as to prevent light emitted from a light source from being directly projected onto the photoelectric conversion elements. The light emitted from the light source is reflected on the document and then projected onto the photoelectric conversion elements directly or after being reflected by the light reflecting layer.

摘要翻译： 全尺寸图像传感器包括形成在基板上并布置成一行的多个光电转换元件。 每个光电转换元件的感光表面垂直于待扫描的文件。 在基板上形成透明层，以覆盖光电转换元件。 在透明层上形成由遮光构件制成的光反射层，以防止从光源发射的光直接投影到光电转换元件上。 从光源发射的光被反射在原稿上，然后直接或者被光反射层反射投影到光电转换元件上。

公开(公告)号：US4954438A

公开(公告)日：1990-09-04

申请号：US397061

申请日：1989-08-21

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

IPC分类号： C12P19/56 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12R1/465

CPC分类号： C07H15/252 ,  Y10S435/886

摘要： This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while stirring to be absorbed to synthetic resin, followed by desorption from the resin and elution with acetone and the resulting acetone solution containing carborubicin is converted into an antibiotic D788-7 by photo radiation, for obtaining D788-7 in the purified form from the reaction solution. The production yield for D788-7 is extremely high and its use as an antitumor agent can be made possible.

公开(公告)号：US4928024A

公开(公告)日：1990-05-22

申请号：US344405

申请日：1989-04-28

申请人： Isao Shimotsuhama ,  Shinji Emori ,  Yoshio Watanabe ,  Masaya Tamamura

发明人： Isao Shimotsuhama ,  Shinji Emori ,  Yoshio Watanabe ,  Masaya Tamamura

IPC分类号： H03K19/086 ,  H03K19/094

CPC分类号： H03K19/086 ,  H03K19/09436

摘要： An ECL transistor pair is connected in parallel with a third transistor. A complementary signal is applied to the transistor pair. A high level of a signal that is applied to the third transistor is effectively higher than a high level of the input to the pair of transistors; and a low level of the signal applied to the third transistor is effectively lower than the high level of the input to the pair of transistors. The low level input to the third transistor enables the ECL circuit to output the complementary input signal and assures high speed ECL operation. The high level of the input to the third transistor disables the ECL circuit from outputting the complementary input signal.

公开(公告)号：US4887186A

公开(公告)日：1989-12-12

申请号：US337594

申请日：1989-04-12

申请人： Takeshi Takeda ,  Sohji Tsuchiya ,  Yoshio Watanabe ,  Satoshi Sekido

发明人： Takeshi Takeda ,  Sohji Tsuchiya ,  Yoshio Watanabe ,  Satoshi Sekido

IPC分类号： H01G4/008 ,  H01L41/047 ,  H01L41/083

CPC分类号： H01G4/008 ,  B32B18/00 ,  C01G3/006 ,  C04B35/2683 ,  C04B35/4504 ,  C04B35/4682 ,  C04B35/497 ,  C04B35/6342 ,  H01L41/0471 ,  H01L41/0478 ,  H01L41/1871 ,  C01P2002/34 ,  C01P2006/40 ,  C04B2235/3203 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3227 ,  C04B2235/3251 ,  C04B2235/3258 ,  C04B2235/3272 ,  C04B2235/3296 ,  C04B2235/445 ,  C04B2235/449 ,  C04B2235/656 ,  C04B2235/768 ,  C04B2235/9615 ,  C04B2237/34 ,  C04B2237/346 ,  C04B2237/704

摘要： A multi-layered dielectric element serving as a capacitor or actuator which comprises a dielectric unit including a plurality of dielectric layers made of a perovskite oxide and a plurality of internal electrode layers sandwiched between the respective dielectric layers. The internal electrodes are each made of at least one conductive composite oxide of La, Ba and Cu having a perovskite-like structure wherein the atomic ratios of the metals are such that (La+Ba)/Cu=1 and La/Ba=4, or at least one conductive composite oxide of La, Sr and Cu having a perovskite-like structure wherein the atomic ratios of the metals are such that (La+Sr)/Cu=1 and La/Sr=3 or 4. The unit is sintered at a temperature of from 900.degree. to 1100.degree. C., so that interdiffusion of metal ions between the dielectric layers and the internal electrode layers is suppressed to a significant extent.

公开(公告)号：US4855817A

公开(公告)日：1989-08-08

申请号：US74998

申请日：1987-07-14

申请人： Yoshio Watanabe

发明人： Yoshio Watanabe

IPC分类号： H04N1/028 ,  H04N1/04 ,  H04N1/19 ,  H04N1/48

CPC分类号： H04N1/486 ,  H04N3/1581

摘要： Sets of color filters are located so that one color filter is above each photoelectric conversion element and each set of color filters forms a pixel. An optical diffusion member is provided over each set of color filters to cause the diffusion of light incident on the color filters. Light shields are placed between each optical diffusion member to shield each optical diffusion member.

摘要翻译： 一组滤色器的位置使得一个滤色器位于每个光电转换元件之上，并且每组滤色器形成一个像素。 在每组彩色滤光片上设置一个光学漫射元件，以使入射到滤色片上的光的扩散。 光屏蔽被放置在每个光学漫射构件之间以屏蔽每个光学漫射构件。